Andrea Ries Thurman
Eastern Virginia Medical School
PharmacokineticsMicrobicides for sexually transmitted diseasesInternal medicineIntensive care medicineMicrobicideAdverse effectImmunologyPlaceboMedroxyprogesterone acetateSemenMenstrual cyclePregnancyBacterial vaginosisPopulationGynecologyHuman immunodeficiency virus (HIV)PhysiologyHormoneMedicineBiologyImmune system
44Publications
13H-index
667Citations
Publications 47
Newest
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#1Andrew T. Gustin (UMN: University of Minnesota)H-Index: 3
#2Andrea Ries Thurman (EVMS: Eastern Virginia Medical School)H-Index: 13
Last. Nichole R. Klatt (UMN: University of Minnesota)H-Index: 29
view all 9 authors...
ABSTRACT null null Background null Bacterial vaginosis– a condition defined by a shift from Lactobacillus dominance to a polymicrobial, anaerobic bacterial community - increases the risk of acquiring sexually transmitted infections and other complications of the female reproductive tract . Antibiotic treatment frequently fails to return the microbiome to an optimal Lactobacillus-dominated state. No criteria currently exist to identify patients likely to experience treatment failure. null null nu...
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#1Terry A. Jacot (EVMS: Eastern Virginia Medical School)H-Index: 5
#2Meredith R. Clark (EVMS: Eastern Virginia Medical School)H-Index: 21
Last. Gustavo F. Doncel (EVMS: Eastern Virginia Medical School)H-Index: 48
view all 10 authors...
Strict adherence to antiretroviral-based microbicide use is important for effective HIV prevention. We previously developed a composite measure of product adherence, protocol compliance, and semen exposure for determining vaginal use of tenofovir (TFV) 1% gel applicators through biomarkers and residual drug analyses. In this study, we tested the ability of the composite measure in vaginally used TFV gel applicators from a Phase III HIV prevention clinical trial. Used vaginal gel applicators from...
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#1Andrea Ries Thurman (EVMS: Eastern Virginia Medical School)H-Index: 13
#2Jill L. Schwartz (EVMS: Eastern Virginia Medical School)H-Index: 21
Last. Gustavo F. Doncel (EVMS: Eastern Virginia Medical School)H-Index: 48
view all 11 authors...
Abstract Background Daily oral emtricitabine (FTC, F)/tenofovir disoproxil fumarate (TDF) combination is approved for HIV pre-exposure prophylaxis (PrEP) in men and women. Tenofovir alafenamide fumarate (TAF) is a newer, more potent prodrug of tenofovir (TFV), and in combination with FTC, has recently been approved for prevention of HIV through rectal transmission. Methods This Phase I, prospective, interventional, randomized study was conducted in three clinical sites: PROFAMILIA, Santo Domingo...
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#1Christina Lee (UM: University of Michigan)H-Index: 6
#2Ryan K. Cheu (UM: University of Miami)H-Index: 4
Last. Kelly B. Arnold (UM: University of Michigan)H-Index: 20
view all 10 authors...
Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure and recurrence rates remain high. To understand complex interactions between Gardnerella vaginalis and Lactobacillus involved in efficacy, here we develop an ordinary differential ...
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#1Sharon AndersonH-Index: 9
#2Andrea Ries ThurmanH-Index: 13
Last. Gustavo F. DoncelH-Index: 48
view all 11 authors...
While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediato...
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#1H. RamadanH-Index: 1
#2Tarita Pakrashi (EVMS: Eastern Virginia Medical School)H-Index: 4
Last. Gerard CeliaH-Index: 3
view all 5 authors...
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#1Andrea Ries Thurman (EVMS: Eastern Virginia Medical School)H-Index: 13
#2Neelima Chandra (EVMS: Eastern Virginia Medical School)H-Index: 14
Last. Gustavo F. Doncel (EVMS: Eastern Virginia Medical School)H-Index: 48
view all 13 authors...
Abstract Reproductive age women may choose to concurrently use topical antiretrovirals and hormonal contraceptives (HCs) to simultaneously prevent HIV-1 infection and unintended/mistimed pregnancy....
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#1Andrea Ries Thurman (EVMS: Eastern Virginia Medical School)H-Index: 13
#2Tina D. Cunningham (EVMS: Eastern Virginia Medical School)H-Index: 15
Last. Gustavo F. Doncel (EVMS: Eastern Virginia Medical School)H-Index: 48
view all 7 authors...
Abstract Objectives To evaluate a lactic-acid-containing diaphragm gel (Contragel®) approved outside the United States for use with a silicone rubber diaphragm (Caya®). The study gel is being evaluated as a safer alternative to nonoxynol-9 (N-9) gel, which has been associated with risk of increasing susceptibility to human immunodeficiency virus (HIV). Study design This was a Phase I randomized, parallel study evaluating the safety of the novel diaphragm gel versus hydroxyethylcellulose (HEC) un...
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