Hao Yu
Jilin University
GeneInternal medicineEndocrinologyGenotypeUnfolded protein responsemicroRNAGene expressionSingle-nucleotide polymorphismMolecular biologyEndoplasmic reticulumTranscriptomeAndrologyChemistryApoptosisHaplotypeOxidative stressLinkage disequilibriumCancer researchViability assayGeneticsCell growthReprogrammingBiologyCell biology
Publications 60
#1Li Yao (Fudan University)H-Index: 4
#2Heming Wang (NEFU: Northeast Forestry University)H-Index: 3
Last. Yicheng Zhao ('PBOC': People's Bank of China)H-Index: 7
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: Adenosine-to-inosine (A-to-I) editing by adenosine deaminase acting on the RNA (ADAR) proteins is one of the most frequent modifications during post- and co-transcription. To facilitate the assignment of biological functions to specific editing sites, we designed an automatic online platform to annotate A-to-I RNA editing sites in pre-mRNA splicing signals, microRNAs (miRNAs) and miRNA target untranslated regions (3' UTRs) from human (Homo sapiens) high-throughput sequencing data and predict t...
5 CitationsSource
#1Hao Yu (CAS: Chinese Academy of Sciences)H-Index: 8
#2Jiankun Yang (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Changhe Zhou (CAS: Chinese Academy of Sciences)H-Index: 2
view all 6 authors...
Abstract An improved chemical etching method named as etch pit real-time observation (EPRTO) method was proposed for the measurement and evaluation of the defects in Cd 1−x Zn x Te materials. Unlike the traditional defect chemical etching method in which the etch pits (EPs) are measured after etching with a fixed time, by using EPRTO method, the EPs can be characterized while etching. A special etching apparatus is designed to observe and record the whole formation process of the surface EPs und...
2 CitationsSource
#1Xin Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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ABSTRACTZearalenone (ZEA) is a mycotoxin that is mainly produced by Fusarium fungi in food and feed. It causes many adverse effects on mammals, but there is little research on the effects of ZEA on intestinal mucosal immunity and intestinal flora in animals or humans. In this study, we aimed to explore the effects of short-term ZEA exposure on mucosal immunity and the microecological balance of the intestine. We found that the morphological structure of the intestinal mucosa in mice was severely...
10 CitationsSource
#1Yunyun Cheng (JLU: Jilin University)H-Index: 6
#2Songcai Liu (JLU: Jilin University)H-Index: 7
Last. Linlin Hao (JLU: Jilin University)H-Index: 8
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Abstract Context Insulin like growth factor 1 (IGF1) is privotal in the regulation of animal growth and is a single-chain globular protein composed of B, C, A, and D regions, of which the C region is involved in maintaining high affinity binding to the IGF1 receptor (IGF1R). Purpose In this study, significant expression differences between large pigs and miniature pigs were detected and only one synonymous SNP (c.258G>A) in the C region of the coding sequence of IGF1 gene was screened. The aim o...
7 CitationsSource
#1Chaogang Yao (JLU: Jilin University)H-Index: 5
#2Daxin Pang (JLU: Jilin University)H-Index: 16
Last. Hao Yu (JLU: Jilin University)H-Index: 8
view all 7 authors...
#1Chen Lyu (JLU: Jilin University)H-Index: 1
#2Wenyue Li (JLU: Jilin University)H-Index: 2
Last. Nan WangH-Index: 2
view all 13 authors...
: To perform a systematic review of the relevant literature about clinical trials on efficacy and safety of immune checkpoint inhibition, whether it is used alone, in combination or with other targeted therapies in patients with advanced and metastatic renal cell carcinoma (RCC), two team members reviewed the abstracts and selected pertinent articles from the relevant databases. A narrative review of randomized controlled trials was performed and seven randomized controlled trials were identifie...
2 CitationsSource
#1Qingyan Wu (JLU: Jilin University)H-Index: 6
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Linlin Hao (JLU: Jilin University)H-Index: 8
view all 10 authors...
Polymorphisms in regions upstream of transcription initiation site may modify the transcriptional activity of target genes by changing promoter activity. This study aims to determine whether or not polymorphisms at porcine IGFBP7 promoter region affect gene expression. In this study, eight SNPs and one PRE1 insertion in this region were first confirmed. The PRE1 insertion was widespread in 20 Chinese indigenous breeds, but was not observed in three commercial breeds. A perfect linkage disequilib...
4 CitationsSource
#1Xiaodi Zhang (JLU: Jilin University)H-Index: 1
#2Zhichen Kang (JLU: Jilin University)H-Index: 1
Last. Hao Yu (JLU: Jilin University)H-Index: 8
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Abstract Cancer immunotherapy has attracted much attention in recent years because of the ability of immune system to identify tumor cells and limit their growth. Icariin (ICA) is a natural flavonoid glucoside isolated from Epimedium plants and has shown a variety of pharmacological activities such as anti-inflammatory effects, immunological regulation and anticancer potency. Furthermore, it has immunoadjuvant effects on enhancing Th1-immune response, suggesting that ICA may serve as an adjuvant...
6 CitationsSource
#1Zhiren Zhang (JLU: Jilin University)H-Index: 6
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Ziyi LiH-Index: 14
view all 7 authors...
Background/Aims: Aberrantly high levels of H3K4me3, caused by incomplete epigenetic reprogramming, likely cause a low efficiency of somatic cell nuclear transfer
16 CitationsSource
#1Yanhui Zhai (JLU: Jilin University)H-Index: 5
#2Zhiren Zhang (JLU: Jilin University)H-Index: 6
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 10 authors...
BACKGROUND/AIMS: DNA methylation and histone modifications are essential epigenetic marks that can significantly affect the mammalian somatic cell nuclear transfer (SCNT) embryo development. However, the mechanisms by which the DNA methylation affects the epigenetic reprogramming have not been fully elucidated. METHODS: In our study, we used quantitative polymerase chain reaction (qPCR), Western blotting, immunofluorescence staining (IF) and sodium bisulfite genomic sequencing to examine the eff...
6 CitationsSource