Hao Yu
Jilin University
GeneInternal medicineEndocrinologyGenotypeUnfolded protein responsemicroRNAGene expressionSingle-nucleotide polymorphismMolecular biologyEndoplasmic reticulumTranscriptomeAndrologyChemistryApoptosisHaplotypeOxidative stressLinkage disequilibriumCancer researchViability assayGeneticsCell growthReprogrammingBiologyCell biology
61Publications
8H-index
239Citations
Publications 60
Newest
#1Hongwei Geng (JLU: Jilin University)H-Index: 2
#2Linlin Hao (JLU: Jilin University)H-Index: 8
Last. Huayi Lu (JLU: Jilin University)H-Index: 1
view all 11 authors...
Insulin-like growth factor 1 (IGF1) is pivotal in the regulation of animal growth. Highly polymorphic CA repeat microsatellites have been identified in the IGF1 promoter region of different breeds of pigs. Previous studies showed that CA repeat microsatellites are associated with circulating IGF1 level. However, the mechanisms by which CA repeat microsatellites regulate IGF1 expression remain unclear. This study aimed to detect the association of CA repeat microsatellites with the transcriptiona...
1 CitationsSource
#1Jing ZhangH-Index: 5
#2Xin WangH-Index: 4
Last. Hao YuH-Index: 8
view all 11 authors...
1 CitationsSource
#1Qi Li (JLU: Jilin University)H-Index: 3
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
Abstract Aims The present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis. Main methods Female C57BL/6 mice were treated with a single intraperitoneal injection of 70 mg/kg CTX. Serum levels of estradiol (E2) and follicle stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay (ELISA), and follicular structure differences were observed by hematoxylin a...
2 CitationsSource
#1Xin Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 11 authors...
Abstract Mounting evidence has shown that zearalenone (ZEA) can have toxic effects on the intestinal epithelial cells (IECs) of mammals and humans, but the mechanism of ZEA-induced toxicity on IECs is unclear. The aim of this study was to reveal the mechanism of action of ZEA on intestinal epithelial cells via RNA-seq technology. We measured the effects of ZEA on the viability and lactate dehydrogenase (LDH) activity of the pig intestinal epithelial cell line J2 (IPEC-J2). The results showed ZEA...
4 CitationsSource
#1Yurong Fu (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 14 authors...
ABSTRACT Zearalenone (ZEA) is a common mycotoxin produced by fungi within the genus Fusarium. However, few studies have examined the direct effects of the toxin on the mammary glands. In the present study, the effects of ZEA treatment on bovine mammary epithelial cells (MAC-T) from dairy cows were investigated. The cells were treated with different concentrations of ZEA to evaluate the effect of the toxin on cell viability, intracellular reactive oxygen species (ROS) concentrations, mitochondria...
5 CitationsSource
#1Junmei Wang (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 16 authors...
Deoxynivalenol (DON) is a toxic secondary metabolite produced by Fusarium graminearum. It is one of the most common feed contaminants that poses a serious threat to the health and performance of dairy cows. This study investigated the in vitro cytotoxicity of DON on bovine mammary epithelial cells (MAC-T). DON at different concentrations (0.25, 0.3, 0.5, 0.8, 1 or 2 μg/ml) inhibited the growth of MAC-T cells after 24 hr of exposure (p < .001). DON at 0.25 μg/ml increased lactate dehydrogenase (L...
7 CitationsSource
#1Yongfeng Zhou (JLU: Jilin University)H-Index: 5
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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Abstract Aflatoxins are widely occurring food contaminants that are particularly harmful to dairy products and cows. The plant polyphenol resveratrol has been reported to have a good effect on increasing the resistance of cells toward toxins. Therefore, we measured the effects of aflatoxin B1 and resveratrol on the viability of the MAC-T cow mammary epithelial cell line. The appropriate treatment concentrations were assayed (12.81 μM aflatoxin B1 and 43.81 μM resveratrol) to verify the protectiv...
11 CitationsSource
#1Wenzhen Wei (JLU: Jilin University)H-Index: 5
#2Gang Wang (JLU: Jilin University)H-Index: 4
Last. Linlin Hao (JLU: Jilin University)H-Index: 8
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Insulin-like growth factor-1 (IGF-1) is a functional candidate gene for pig growth and development due to its crucial role in the growth axis of growth hormone-IGF-1. Considering that the 3′ untranslated region (3′UTR) of gene may affect its expression, we analyzed the effect of a single-nucleotide polymorphism (SNP) (rs34142920, c.674C > T) on gene expression, cell proliferation, and apoptosis and the possible related molecular mechanisms in PK-15 cells. The SNP was found in the 3′UTR of IGF-1 ...
4 CitationsSource
#1Chaogang Yao (JLU: Jilin University)H-Index: 5
#2Daxin Pang (JLU: Jilin University)H-Index: 16
Last. Hao Yu (JLU: Jilin University)H-Index: 8
view all 7 authors...
Intramuscular fat (IMF) is an important economic trait for pork quality and a complex quantitative trait regulated by multiple genes. The objective of this work was to investigate the novel transcriptional effects of a multigene pathway on IMF deposition in the longissimus dorsi (LD) muscles of pigs. Potential signaling pathways were screened by mining data from three gene expression profiles in the Gene Expression Omnibus (GEO) database. We designed quantitative real-time reverse transcription-...
4 CitationsSource
#1Peixuan Huang (JLU: Jilin University)H-Index: 3
#2Daxin Pang (JLU: Jilin University)H-Index: 16
Last. Hao Yu (JLU: Jilin University)H-Index: 8
view all 9 authors...
Myostatin (MSTN) is a member of the TGF-β superfamily that negatively regulates skeletal muscle growth and differentiation. However, the mechanism by which complete MSTN deletion limits excessive proliferation of muscle cells remains unclear. In this study, we knocked out MSTN in mouse myoblast lines using a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) system and sequenced the mRNA and miRNA transcriptomes. The results show that complete loss of MSTN upregulates seven ...
2 CitationsSource