Hao Yu
Jilin University
GeneInternal medicineEndocrinologyGenotypeUnfolded protein responsemicroRNAGene expressionSingle-nucleotide polymorphismMolecular biologyEndoplasmic reticulumTranscriptomeAndrologyChemistryApoptosisHaplotypeOxidative stressLinkage disequilibriumCancer researchViability assayGeneticsCell growthReprogrammingBiologyCell biology
61Publications
8H-index
239Citations
Publications 60
Newest
#1Ruihua LiH-Index: 4
#2Jing ZhangH-Index: 5
Last. Hao YuH-Index: 8
view all 8 authors...
Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. Curcumin (CUR), a well-known cancer inhibitor, significantly inhibits the viability of breast cancer cells. Through transcriptomic analysis and flow cytometry experiments, it was found that after 48 hours of treatment of breast cancer cells at its half maximal inhibitory concentration (IC50), curcumin suppressed the viability of cancer cells via induction of ferroptotic death. Use of the ...
3 CitationsSource
#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 10 authors...
Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies. Chemotherapy is the main clinical therapy, but the effective screening strategy for chemotherapy drugs is poorly investigated. Drug repositioning has been the center of attention in recent years attracting numerous studies. Here, we firstly found multiple common features between leukemia and TNBC by analyzing the global transcriptome profile...
Source
#1Siyu ChenH-Index: 6
#2Yingqi JiaH-Index: 2
Last. Zhanjun LiH-Index: 15
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Zetsche, B. et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell 163, 759–771 (2015). CAS PubMed PubMed Central Article Google Scholar Kim, D. et al. Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells. Nat. Biotechnol. 34, 863–868 (2016). CAS PubMed Article Google Scholar Kleinstiver, B. P. et al. Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells. Nat. Biotechnol. 34, 869–874 (2016). CAS PubMed PubMed Central Articl...
1 CitationsSource
#1Siyu Chen (JLU: Jilin University)H-Index: 6
#2Wanhua Xie (Shenyang Medical College)H-Index: 1
Last. Zhanjun Li (JLU: Jilin University)H-Index: 15
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Abstract CRISPR/Cas9-mediated gene knockout and base-editing-associated induction of STOP codons (iSTOP) have been widely used to exterminate function of a coding gene, while they have been reported to exhibit side effects. Here, we propose a novel and practical alternative method referred to as CRISPR Start-Loss (CRISPR-SL), which eliminates gene expression by utilizing both adenine base editors (ABEs) and cytidine base editors (CBEs) to disrupt initiation codon (ATG). CRISPR-SL has been verifi...
3 CitationsSource
#1Rui Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 11 authors...
Grape pomace (GP) is an abundant by-product from wine production and is rich in phenolic compounds, unsaturated fatty acids, dietary fibre and beneficial bacteria. In this study, weaned piglets were fed a basic diet supplemented with 5% GP for 4 weeks. Compared with those in the control (CON) group, it was found that the proportion of Lactobacillus delbrueckii, Olsenella umbonata and Selenomonas bovis in the caecum and the villus height and villus height/crypt depth ratio (VCR) of the jejunum we...
1 CitationsSource
#1Yu Jiang (JLU: Jilin University)H-Index: 3
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Xueming Zhang (JLU: Jilin University)H-Index: 9
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Abstract Although induced pluripotent stem cells (iPSCs) had been generated from several somatic cell types in cattle, their pluripotency and differentiation capacities after freezing/thawing, and the dysregulated transcripts involved in pathways critical for reprogramming were not investigated. Additionally, selection of proper source cells is critical for iPSC derivation because the residual influence of the somatic origin may variegate their differentiation propensity. Sertoli cells (SCs) hav...
2 CitationsSource
#1Meng Chen (JLU: Jilin University)H-Index: 1
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 67
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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ABSTRACT During the transition period, dairy cows are challenged by increased energy demands and decreased dry matter intake, which can induce a variety of metabolic disorders, especially fatty liver. Dairy cows suffering from mild or moderate fatty liver in this period show no distinct clinical symptoms, indicating the occurrence of adaptive processes. The process of autophagy (an adaptive response) leads to degradation of intracellular components to generate energy and maintains cellular homeo...
1 CitationsSource
#1Jia Wang (JLU: Jilin University)H-Index: 2
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Songcai Liu (JLU: Jilin University)H-Index: 7
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Background: Chickpea isoflavones have been demonstrated to play an inhibitory role in breast cancer cells. In this study, we aimed to explore the mechanism of chickpea isoflavones inhibiting the formation and development of breast carcinoma through the integration of wet and dry experiments. Methods: Chickpea isoflavones were added to the MCF-7 cells for 48 hours, and the subsequent morphological changes of cells were observed using an inverted microscope, while apoptosis was quantified by flow ...
3 CitationsSource
#1Hao Li (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
Background: 6-thioguanine (6-TG), as a conventional "ancient" drug for the treatment of acute leukemia, has been proved to have extensive anti-tumor roles. This study was created to investigate the hidden function of 6-TG on the MCF-7 breast cancer cell line (ER+, PR+) and its mechanisms. Methods: MCF-7 cells were treated with 6-TG, and the IC50 value was measured by a cell counting kit-8 assay. Differentially expressed genes (DEGs) were confirmed by RNA-seq analysis. Apoptosis and cell cycle co...
2 CitationsSource
#1Liyan Sui (JLU: Jilin University)H-Index: 2
#2Rong Huang (JLU: Jilin University)H-Index: 2
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
Histone deacetylase 6 (HDAC6) participates in mouse oocyte maturation by deacetylating alpha-tubulin. However, how HDAC6 expression is regulated in oocytes remains unknown. In the present study, we discovered that mouse oocytes had a high level of HDAC6 expression and a low level of DNA methylation status in their promoter region. Then, a selective HDAC6 inhibitor, tubastatin A (Tub-A) was chosen to investigate the role of HDAC6 in oocyte maturation. Our results revealed that inhibition of HDAC6...
6 CitationsSource