Li An
China Pharmaceutical University
MetabolomeCarbohydrate metabolismChemistryTraditional Chinese medicineMetabolomicsOxidative stressLiver injuryAlcoholic liver diseaseDimethylglycineGlutamineCreatineLipid peroxidationHypoxanthineLipid metabolismBiochemistryMolecular medicineMedicinePharmacology
Publications 2
#1Li An (CPU: China Pharmaceutical University)H-Index: 2
#2Qiaoling Lang (CPU: China Pharmaceutical University)H-Index: 1
Last. Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
view all 5 authors...
: Alcoholic liver disease (ALD) is a leading cause of liver‑associated morbidity and mortality. Zhi‑Zi‑Da‑Huang decoction (ZZDHD), a traditional Chinese medicine formula, has been frequently used to treat or alleviate the symptoms of the various stages of ALD. To identify metabolic changes and the ZZDHD mechanism of action on ALD, potential urine biomarkers involved in the effects of ZZDHD were identified. Additionally, dynamic metabolomic profiles were systematically analyzed using nuclear magn...
4 CitationsSource
#1Li An (CPU: China Pharmaceutical University)H-Index: 2
#2Qingshui ShiH-Index: 2
Last. Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
view all 3 authors...
Zhi-Zi-Da-Huang decoction (ZZDHD), a Traditional Chinese Medicine (TCM) formula, has been widely used for the treatment of alcohol-induced liver injury for many years. To comprehensively explore the possible mechanism of the hepatoprotective effects of ZZDHD, a nuclear magnetic resonance (NMR)-based metabolomics study, 1H NMR spectra combined with pattern recognition methods including PCA and OPLS-DA, was applied to identify potential plasma and liver biomarkers responsible for the positive effe...
12 CitationsSource