Minsheng Chen
Southern Medical University
Self-healing hydrogelsDownregulation and upregulationEndocrinologyCardiologyReceptorChemistryIn vivoCombinatorial chemistryCardiac fibrosisPressure overloadPuerarinPeptideFibrosisAngiotensin IIMyocardial infarctionSignal transductionMedicineNanofiberSupramolecular chemistryPharmacology
47Publications
16H-index
747Citations
Publications 46
Newest
#1Wenjie Guo (Southern Medical University)
#2Weijing Feng (Southern Medical University)H-Index: 1
Last. Minsheng Chen (Southern Medical University)H-Index: 16
view all 10 authors...
The reconstruction of blood perfusion is a crucial therapeutic method to save and protect cardiac function after acute myocardial infarction (AMI). The activation of the hepatocyte growth factor precursor (pro-HGF) has a significant effect on promoting angiogenesis and antiapoptosis. The oxygen/glucose deprivation (OGD) caused by AMI could induce vascular adventitia fibroblasts to differentiate into myofibroblasts and secrete the pro-HGF. Meanwhile, the specific Met receptor of the hepatocyte gr...
Source
#1Wenjie Guo (Southern Medical University)
#2Weijing Feng (Southern Medical University)H-Index: 1
Last. Minsheng Chen (Southern Medical University)H-Index: 16
view all 6 authors...
Hypertrophic cardiomyopathy (HCM) is one of the most common genetic heart diseases. Its features include abnormal cardiomyocyte hypertrophy, microvascular dysfunction, and increased accumulation of intercellular matrix. We aim to unravel genes associated with the pathogenesis of HCM and provide a potential target for diagnosis and treatment. Key modules were identified by weighted gene co-expression network analysis (WGCNA). A miRNA-mRNA network was constructed with the predicted miRNA and the m...
Source
#1Anbiao Wu (Southern Medical University)
#2Lihong Zhang (Southern Medical University)
Last. Qicai Liu (Southern Medical University)H-Index: 3
view all 7 authors...
Cardiac fibrosis is an important pathological change after myocardial infarction (MI). Its progression is essential for post-MI infarct healing, during which transforming growth factor beta1 (TGF-β1) plays a critical role. Limb-bud and Heart (LBH), a newly discovered target gene of TGF-β1, was shown to promote normal cardiogenesis. αB-crystallin (CRYAB), an LBH-interacting protein, was demonstrated to be involved in TGF-β1-induced fibrosis. The roles and molecular mechanisms of LBH and CRYAB dur...
Source
#1Zhanpeng Wen (Southern Medical University)H-Index: 1
Last. Minsheng ChenH-Index: 16
view all 11 authors...
Source
#1Ning Hou (Guangzhou Medical University)H-Index: 12
#2Yin Huang (Guangzhou Medical University)H-Index: 2
Last. Cheng-Feng Luo (Guangzhou Medical University)H-Index: 7
view all 16 authors...
Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy. Previous evidence suggests that puerarin, a phytoestrogen, exerts beneficial effects on cardiac function in patients with cardiac hypertrophy. In this study, we investigated whether puerarin could prevent cardiac hypertrophy and remodeling in ovariectomized, aortic-banded rats. Female SD rats subjected to bilateral ovariectomy...
1 CitationsSource
#1Xianmei Pan (Southern Medical University)
#2Bo Wu (Southern Medical University)H-Index: 1
Last. Minsheng Chen (Southern Medical University)H-Index: 16
view all 6 authors...
Yes-associated protein (YAP), a major effector of the Hippo signalling pathway, is widely implicated in vascular pathophysiology processes. Here, we identify a new role of YAP in the regulation of vascular senescence. The inhibition or deficiency and overexpression of YAP were performed in human umbilical vein endothelial cells (HUVECs) and isolated vascular tissues. Cellular and vascular senescence was assessed by analysis of the senescence-associated β-galactosidase (SA-β-gal) and expression o...
Source
#1Peier ChenH-Index: 1
#2Ling Wang (Southern Medical University)H-Index: 1
Last. Minsheng ChenH-Index: 16
view all 7 authors...
1 CitationsSource
#1Weijing Feng (Southern Medical University)H-Index: 1
#2Zhibin Li (SYSU: Sun Yat-sen University)
Last. Minsheng Chen (Southern Medical University)H-Index: 16
view all 9 authors...
OBJECTIVE To investigate whether intraindividual variability of fasting glucose (FG) in young adulthood is associated with coronary artery calcification (CAC) progression in middle age. RESEARCH DESIGN AND METHODS We included 2,256 CARDIA (Coronary Artery Risk Development Study in Young Adults) participants with CAC assessment by computed tomography scanner at baseline (2000–2001) and 10 years later (2010–2011). CAC progression was assessed for each individual as the difference of logarithmic CA...
Source
#1Shu-Yuan Ni (Southern Medical University)H-Index: 1
#2Xinglong Zhong (Southern Medical University)H-Index: 5
Last. Minsheng Chen (Southern Medical University)H-Index: 16
view all 8 authors...
Myocardial fibrosis (MFs) is a crucial pathological process that results in cardiac failure in the development of multiple cardiovascular diseases. Puerarin could reportedly be used to treat a variety of cardiovascular diseases. However, the exact mechanism of puerarin on MFs was not clear enough. The separated primary cardiac fibroblasts (CFs) were induced by lipopolysaccharide (LPS) and treated with puerarin. The levels of TNF-alpha, IL-6, HMGB1, PARP-1, alpha-SMA, collagen-1, collagen-3, NF-k...
2 CitationsSource
#1Yuhui Lin (Guangzhou Medical University)H-Index: 1
#2Xiaobin Ni (STU: Shantou University)H-Index: 1
Last. Minsheng Chen (Southern Medical University)H-Index: 16
view all 8 authors...
OBJECTIVE: To study the effect of puerarin on electrophysiology using a hypertrophic cardiomyocyte (HC) model. MATERIALS AND METHODS: Human urine epithelial cells were used to generate the HC model (hiPSC-CM). Cardiomyocyte hypertrophy was induced by applying 10 nM endothelin-1 (ET-1). Effects of puerarin pre-treatment (PPr) and post-treatment (PPo) on action potential, sodium current (INa) activation and inactivation, and recovery following INa inactivation were tested using patch clamp electro...
1 CitationsSource