Suliman Khan
Zhengzhou University
OutbreakCancerInternal medicineBiodiversityVirologyNanotechnologyIntensive care medicineChemistryPediatricsChinaTransmission (medicine)CoronavirusPneumoniaBetacoronavirusDiseaseCoronavirus Infections2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Food scienceCancer researchMedicineBiologyPandemicPharmacologyEnvironmental health
111Publications
17H-index
2,223Citations
Publications 79
Newest
Abstract Aggregation of tau protein into the form of insoluble amyloid fibrils is linked with Alzheimer's disease. The identification of potential small molecules that can inhibit tau protein from undergoing aggregation has received a great deal of interest, recently. In the present study, the possible inhibitory effects of liquiritigenin as a member of chiral flavanone family on tau amyloid fibrils formation and their resulting neurotoxicity were assessed by different biophysical and cellular a...
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#1Yang Shi (Zhengzhou University)H-Index: 2
#2Zheng Xiang (Zhengzhou University)
Last. Bing-Rong Liu (Zhengzhou University)H-Index: 2
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Histone acetylation which regulates about 2-10% of genes has been demonstrated to be involved in tumorigenesis of esophageal squamous cell carcinoma (ESCC). In this study, we investigated the treatment response of ESCC to selective histone deacetylase inhibitor (HDACi) LMK-235 and potential biomarker predicting the treatment sensitivity. We identified tensin-3 (TNS3) which was highly over-expressed in ESCC as one of the down-regulated genes in response to LMK-235 treatment. TNS3 was found positi...
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Last. Suliman Khan (Zhengzhou University)H-Index: 17
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Abstract A novel, highly sensitive, simple, and rapid strategy was designed and developed for simultaneous determination of cabozantinib (CBZ) as an anticancer agent and its main metabolites including monohydroxy sulfate (EXEL-1646), N-oxide (EXEL-5162(, amide cleavage product (EXEL-5366), and 6-desmethyl amide cleavage product sulfate) EXEL-1644). Measurements were done through a micellar liquid chromatography (MLC) method coupled with fluorescence detection. The high-performance liquid chromat...
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#1Suliman Khan (Zhengzhou University)H-Index: 17
#2Rabeea Siddique (Zhengzhou University)H-Index: 15
Last. Hu Bowen (Zhengzhou University)
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Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individual’s quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approac...
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#1Suliman Khan (Zhengzhou University)H-Index: 17
#2Majid Sharifi (IAU: Islamic Azad University)H-Index: 15
Last. Mojtaba Falahati (IAU: Islamic Azad University)H-Index: 23
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Abstract Background Heterocyclic compounds have always been used as a core portion in the development of anticancer drugs. However, there is a pressing need for developing inexpensive and simple alternatives to high-cost and complex chemical agents-based catalysts for large-scale production of heterocyclic compounds. Also, development of some smart platforms for cancer treatment based on nanoparticles (NPs) which facilitate Fenton reaction have been widely explored by different scientists. Magne...
1 CitationsSource
#1Rabeea Siddique (Zhengzhou University)H-Index: 15
#2Qian Bai (Zhengzhou University)H-Index: 4
Last. Suliman Khan (Zhengzhou University)H-Index: 17
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A novel coronavirus (2019-nCov) emerged in China, at the end of December 2019 which posed an International Public Health Emergency, and later declared as a global pandemic by the World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) named it SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), while the disease was named COVID-19 (Coronavirus Disease- 2019). Many questions related to the exact mode of transmission, animal origins, and antiviral thera...
1 CitationsSource
#1Qichen Pan (PRC: China Medical University (PRC))
#2Yunchao Ban (PRC: China Medical University (PRC))
Last. Suliman Khan (Zhengzhou University)H-Index: 17
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Abstract Protein misfolding and aggregation result in induction of a number of neurodegenerative diseases. In the present study, the anti-fibrillation activity of calycosin and its influence on the kinetics of amyloid formation of α-synuclein (α-syn) and associated cytotoxicity on neuron-like cells (PC-12) as a model of Parkinson's disease were explored. Therefore, in combination with ThT and ANS fluorescence assay, CD, Congo red absorbance, TEM and cytotoxicity assays (MTT, ROS, SOD activity, C...
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#1Majid Sharifi (University of Tabriz)H-Index: 15
#1Majid Sharifi (Zhengzhou University)
Last. Mojtaba Falahati (IAU: Islamic Azad University)H-Index: 23
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Abstract The bioprinting technique with specialized tissue production allows the study of biological, physiological, and behavioral changes of cancerous and non-cancerous tissues in response to pharmacological compounds in personalized medicine. To this end, to evaluate the efficacy of anticancer drugs before entering the clinical setting, tissue engineered 3D scaffolds containing breast cancer and derived from the especially patient, similar to the original tissue architecture, can potentially ...
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#1Suliman Khan (Zhengzhou University)H-Index: 17
#2Farnoosh AttarH-Index: 17
Last. Mojtaba Falahati (IAU: Islamic Azad University)H-Index: 23
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Abstract The outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in 2019, have highlighted the concerns about the lack of potential vaccines or antivirals approved for inhibition of CoVs infection. SARS-CoV-2 RNA dependent RNA polymerase (RdRp) which is almost preserved across different viral species can be a potential target for development of antiviral drugs, including nucleoside analogues (NA). However, ExoN proofreading activity of CoVs leads to their protection from se...
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#1Suliman Khan (Zhengzhou University)H-Index: 17
#2Majid Sharifi (University of Tabriz)H-Index: 15
Last. Mojtaba Falahati (IAU: Islamic Azad University)H-Index: 23
view all 6 authors...
Abstract Researchers have recently introduced some artificial enzymes based on nanomaterials that show significant catalytic activity relative to native enzymes called nanozyme. These nanozymes show superior performance than conventional catalysts and are considered as fascinating candidates for introducing the next generation of biomaterials in various industrial and biomedical fields. Recently, nanozymes have received a great deal of attention in biomedical applications due to their potential ...
1 CitationsSource