Lixin Huang
Nanchang University
PolysaccharideFunction (biology)SulfationChemistrySplenocyteSuperoxide dismutaseTLR4Oxidative stressCyclocaryaPaliurusAntioxidantUronic acidMalondialdehydeGlutathione peroxidaseMesona chinensisFood scienceGut floraBiochemistryMolecular massImmune systemPharmacology
13Publications
7H-index
239Citations
Publications 14
Newest
#1Yuzhen Hong (NCU: Nanchang University)H-Index: 3
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 5 authors...
Abstract null null There are a number of health benefits of Mesona chinensis Benth polysaccharide (MP), but little is known about its hepatoprotective effect and effect on gut microbiota composition in mice with liver damage induced by cyclophosphamide (CTX). This study indicated that MP supplementation effectively inhibited the production of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), enhanced liver antioxidant capacity and repaired liver damage in mice caused by ...
Source
#1Ting Wu (NCU: Nanchang University)H-Index: 5
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 9 authors...
Abstract The purpose of this paper was to investigate the effects of Cyclocarya paliurus polysaccharide (CP) on gut microbiota composition and predict metabolic function in healthy mice. Healthy Kunming mice were continuously gavaged with CP for 20 days, and mouse feces were collected for analysis. The results showed that CP could remarkably increase the short-chain fatty acids (SCFAs; acetic acid, propionic acid, butyric acid, and valeric acid) in the feces of healthy mice in a dose-dependent m...
Source
#1Xianxiang Chen (NCU: Nanchang University)H-Index: 1
#2Yikun Wang (NCU: Nanchang University)H-Index: 1
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 7 authors...
The water-soluble non-starch polysaccharides isolated from natural resources have become research hotpots in the field of food science and human health due to widely distributed in nature and low toxicity. It has indicated that the health-promoting effect of water-soluble non-starch polysaccharides were partly attributable to against excessive oxidative stress. Indeed, excessive oxidative stress in the body has been reported in occurrence of disease. The water-soluble non-starch polysaccharides ...
3 CitationsSource
#1Mingyue Shen (NCU: Nanchang University)H-Index: 29
#2Xianxiang Chen (NCU: Nanchang University)H-Index: 1
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 6 authors...
Abstract A sulfated polysaccharide (SMP) from the Mesona chinensis Benth was successfully obtained and its immunomodulatory effects were evaluated. Results showed that SMP exhibited the proliferation effects in splenocytes in vitro and ameliorated the impaired of splenocytes in Cy-treated mice. SMP induced the production of nitric oxide (NO), interleukin (IL) −2, interferon-γ (IFN-γ), increased the expression of antioxidant enzymes (SOD and CAT), and reduced the production of malondialdehyde (MD...
3 CitationsSource
#1Ting Wu (NCU: Nanchang University)H-Index: 5
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 8 authors...
Abstract The study was to investigate the anti-inflammatory effect of Cyclocarya paliurus polysaccharides (CP) on carbon tetrachloride (CCl4) induced mice and explore its underlying mechanism. Based on a mouse model of CCl4 induced liver inflammation and pretreatment with CP. Results showed that CP significantly decreased the levels of the proinflammatory cytokines (NO, TNF-α, IL-1β) as well as the proteins expression levels of COX-2 and iNOS in the liver. TLR4 and MAPK pathways were down-regula...
11 CitationsSource
#1Lixin Huang (NCU: Nanchang University)H-Index: 7
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 7 authors...
Abstract In this study, the immune responses of Mesona chinensis Benth polysaccharides (MP) in vitro and in vivo were investigated. Results showed that MP presented immunomodulatory activities on macrophages and T lymphocytes in vitro. Compared with the cyclophosphamide (Cy)-induced immunosuppressive mice, the body weights, spleen indexes (3.45 to 4.91) and thymus indexes (0.78 to 1.04) of the mice treated with MP were increased, and the peripheral blood levels were recovered. MP treatment also ...
9 CitationsSource
#1Liuming Xie (NCU: Nanchang University)H-Index: 2
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 6 authors...
Abstract With the rising trend of incidence of cancers, effective therapies are urgently needed to control human malignancies. However, the chemotherapy drugs currently on the market cause serious side effects. Polysaccharides belong to a class of biomacromolecules, which have drawn considerable research interest over the years as it possess anti-cancer activities or can increase the efficacy of conventional chemotherapy drugs with fewer side effects. The antitumor activity of many polysaccharid...
47 CitationsSource
#1Yue Yu (NCU: Nanchang University)H-Index: 6
#2Qianqian Song (NCU: Nanchang University)H-Index: 8
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 7 authors...
Abstract Two sulfated polysaccharides SCP3 and SCP5 with degree of substitution (DS) 0.45 and 0.13 were obtained by modifying the Cyclocarya paliurus polysaccharide (CP) with chlorosulfonic acid-pyridine method. Results demonstrated that the physicochemical properties, molar ratios of monosaccharide composition, molecular weights, and in vitro immunomodulatory activity were changed after being sulfated. Splenocytes proliferation assay showed that both CP and sulfated polysaccharides have immunom...
12 CitationsSource
#1Qianqian Song (NCU: Nanchang University)H-Index: 8
#2Lian Jiang (NCU: Nanchang University)H-Index: 11
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 8 authors...
Abstract A water-soluble polysaccharide (MBP-1) was isolated from Mung bean (Vigna radiate L.) and its physicochemical characterization, functional properties, and antioxidant activity was investigated. Chemical analysis revealed that the contents of carbohydrate, uronic acid, and protein were 33.05 ± 0.10%, 25.83 ± 0.04%, and 3.17 ± 0.36%, respectively. The molecular weight (Mw) of MBP-1 was 146.22 kDa and it was consist of arabinose (Ara), glucose (Glc), xylose (Xyl), galactose (Gal), and gala...
9 CitationsSource
#1Lixin Huang (NCU: Nanchang University)H-Index: 7
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 4 authors...
Abstract Background Polysaccharides are natural macromolecular polymers that are widely distributed in various food resources and have attracted much attention due to their significant bioactivities. Sulfated polysaccharides refer to polysaccharides containing sulfate groups on sugar units. A large number of studies have characterized and evaluated the biological relevance of sulfated polysaccharides, which shows great potential in terms of immunological activity. Scope and approach Through a cr...
51 CitationsSource