Fengxue Zhang
Guangzhou University of Chinese Medicine
BioassayCardiac function curveAcetylationCancerDownregulation and upregulationCell migrationRamachandran plotmicroRNAEmbryonic stem cellCellSmall moleculeRegulation of gene expressionHomology modelingMolecular modelChemistryT cellTumor microenvironmentOxidative stressAnti-inflammatoryDrugAmyrinDoxorubicinHonokiolResidue (chemistry)Ilex asprellaCell cycleChemical diversityMalignant transformationProtein structureCancer researchCarcinogenesisMolecular dynamicsCell growthSignal transductionStereochemistryDrug discoveryDatabaseBiologyImmune systemPharmacologyChemical space
23Publications
11H-index
347Citations
Publications 5
Newest
#1Zhixue Wu (Guangzhou University of Chinese Medicine)H-Index: 1
#2Hui Xu (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Jiangyong Gu (Guangzhou University of Chinese Medicine)H-Index: 3
view all 10 authors...
Amyrins are the immediate precursors of many pharmaceutically important pentacyclic triterpenoids. Although various amyrin synthases have been identified, little is known about the relationship between protein structures and the constituent and content of the products. IaAS1 and IaAS2 identified from Ilex asprella in our previous work belong to multifunctional oxidosqualene cyclases and can produce α-amyrin and β-amyrin at different ratios. More than 80% of total production of IaAS1 is α-amyrin;...
2 CitationsSource
#1Kun Wang (Guangzhou University of Chinese Medicine)H-Index: 9
#2Jianyong Xiao (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Jiangyong Gu (Guangzhou University of Chinese Medicine)H-Index: 3
view all 15 authors...
Systemic or local inflammation drives the pathogenesis of various human diseases. Small compounds with anti-inflammatory properties hold great potential for clinical translation. Over recent decades, many compounds have been screened for their action against inflammation-related targets. Databases that integrate the physicochemical properties and bioassay results of these compounds are lacking. We created an “Anti-Inflammatory Compounds Database” (AICD) to deposit compounds with potential anti-i...
5 CitationsSource
#1Xun Li (SCNU: South China Normal University)H-Index: 3
#2Mingtian Zhong (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Xiaodong Ma (Guangzhou University of Chinese Medicine)H-Index: 8
view all 11 authors...
Background Our previous report demonstrated that genetic ablation of miR-301a reduces Kras-driven lung tumorigenesis in mice. However, the impact of miR-301a on host anti-tumor immunity remains unexplored. Here we assessed the underlying molecular mechanisms of miR-301a in the tumor microenvironment.
20 CitationsSource
#1Mingtian Zhong (Guangzhou University of Chinese Medicine)H-Index: 4
#2Zhujuan Huang (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Xiaodong Ma (Guangzhou University of Chinese Medicine)H-Index: 8
view all 10 authors...
Arsenic is a well-known of human carcinogen and miR-301a is an oncogenic microRNA, which links to oncogenesis, however, little is understood about its contribution to arsenic-induced cellular transformation and tumorigenesis. Here, we investigated the role of miR-301a during arsenic-induced cellular transformation and tumor formation. miR-301a was found to be upregulated during arsenic-induced BEAS-2B transformation and the overexpression of miR-301a was dependent on IL-6/STAT3 signaling. Inhibi...
10 CitationsSource
#1Lizhen Huang (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Kailiang Zhang (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Qinglin Yang (UAB: University of Alabama at Birmingham)H-Index: 38
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Honokiol is a key component of a medicinal herb, Magnolia bark. Honokiol possesses potential pharmacological benefits for many disease conditions, especially cancer. Recent studies demonstrate that Honokiol exerts beneficial effects on cardiac hypertrophy and doxorubicin (Dox)-cardiotoxicity via deacetylation of mitochondrial proteins. However, the effects and mechanisms of Honokiol on cardiac mitochondrial respiration remain unclear. In the present study, we investigate the effect of Honokiol o...
30 CitationsSource