Sung Ho Jeon
Hallym University
Downregulation and upregulationInnate immune systemNatural killer T cellmicroRNAMolecular biologyVirologyProtein kinase RReceptorChemistryNon-coding RNAImmunologyInflammationVault RNAExperimental autoimmune encephalomyelitisCytokineThymocyteCyclodextrinAnti-inflammatoryProgrammed cell deathCancer researchBiochemistryCarcinogenesisSignal transductionRNAMedicineTranscription factorBiologyImmune systemCell biology
47Publications
15H-index
726Citations
Publications 47
Newest
#1Gayoung Lee (Hallym University)
#2Jaehun Jeong (Hallym University)
Last. Moongyu Jang (Hallym University)H-Index: 5
view all 8 authors...
Capacitive biosensors are manufactured on glass slides using the semiconductor process to monitor cell growth and cell–drug interactions in real time. Capacitance signals are continuously monitored for each 10 min interval during a 48 h period, with the variations of frequency from 1 kHz to 1 MHz. The capacitance values showed a gradual increase with the increase in NIH 3T3 cell numbers. After 48 h of growth, 6.67 μg/mL puromycin is injected for the monitoring of the cell–drug interaction. The c...
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#1Kongara Damodar (Hallym University)H-Index: 16
#2Sooyong Shin (Hallym University)H-Index: 2
Last. Jeong Tae Lee (Hallym University)H-Index: 13
view all 4 authors...
Abstract null null The first synthesis of natural phenolic amides, tabamides A–C (1–3), and their derivatives (4–12) was accomplished using Stobbe condensation and amide coupling reactions as key steps. The in vitro nitric oxide (NO) inhibitory effects of these compounds in LPS-induced RAW-264.7 macrophages were evaluated as an indicator of anti-inflammatory activity. All compounds tested had a concentration-dependent inhibitory effect on NO production by RAW-264.7 macrophages without significan...
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#1Hyun-Mo Jeong (Hallym University)H-Index: 2
#2Yeontaek Lee (Hallym University)H-Index: 2
Last. Jae-Hoon Shim (Hallym University)H-Index: 11
view all 9 authors...
Abstract Cyclodextrin glucanotransferase (CGTase; EC 2.4.1.19) produces cycloamyloses (CAs), which are large cyclic glucans, and subsequently transforms them to α-, β-, and γ-cyclodextrins. We developed a novel encapsulation process based on the cyclization activity of CGTase and applied it to the formation of CA inclusion complexes with resveratrol (RVT), which has limited bioavailability due to its low water solubility. The encapsulated RVT (CA-RVT) was purified using preparative high-performa...
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#1Sung Won LeeH-Index: 10
#2Hyun Jung Park (Sejong University)H-Index: 8
Last. Seokmann HongH-Index: 22
view all 9 authors...
We previously showed that ubiquitous overexpression of the chromatin remodeling factor SWItch3-related gene (SRG3) promotes M2 macrophage differentiation, resulting in anti-inflammatory responses in the experimental autoimmune encephalomyelitis model of multiple sclerosis. Since hepatic macrophages are responsible for sepsis-induced liver injury, we investigated herein the capacity of transgenic SRG3 overexpression (SRG3β-actin mice) to modulate sepsis in mice exposed to lipopolysaccharide (LPS)...
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Interferons (IFNs) are a crucial component in the innate immune response. Especially the IFN-β signaling operates in most cell types and plays a key role in the first line of defense upon pathogen intrusion. The induction of IFN-β should be tightly controlled, because its hyperactivation can lead to tissue damage or autoimmune diseases. Activation of the IFN-β promoter needs Interferon Regulatory Factor 3 (IRF3), together with Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB...
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#1Sung Won Lee (Biotechnology Institute)H-Index: 10
#2Hyun Jung Park (Biotechnology Institute)H-Index: 8
Last. Seokmann Hong (Biotechnology Institute)H-Index: 22
view all 9 authors...
The SWItch (SWI)3-related gene (SRG3) product, a SWI/Sucrose Non-Fermenting (SNF) chromatin remodeling subunit, plays a critical role in regulating immune responses. We have previously shown that ubiquitous SRG3 overexpression attenuates the progression of Th1/Th17-mediated experimental autoimmune encephalomyelitis. However, it is unclear whether SRG3 overexpression can affect the pathogenesis of inflammatory skin diseases such as atopic dermatitis (AD), a Th2-type immune disorder. Thus, to eluc...
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#1Sunsook Hwang (SNU: Seoul National University)H-Index: 6
#2Changjin Lee (SNU: Seoul National University)H-Index: 17
Last. Rho Hyun Seong (SNU: Seoul National University)H-Index: 25
view all 13 authors...
CD4/CD8 T-cell lineage differentiation is a key process in immune system development; however, a defined regulator(s) that converts the signal from T-cell receptor and co-receptor complexes into lineage differentiation remains unclear. Here, we show that Twist2 is a critical factor in CD4/CD8 thymocyte differentiation. Twist2 expression is differentially regulated by T-cell receptor signaling, leading to differentiation into the CD4 or CD8 lineage. Forced Twist2 expression perturbed CD4+ thymocy...
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Nc886 is a regulatory non-coding RNA (ncRNA) whose expression is frequently silenced in malignancies. In the case of esophageal squamous cell carcinoma (ESCC), nc886 silencing is associated with shorter survival of patients, suggesting nc886′s tumor suppressor role in ESCC. However, this observation has not been complemented by an in-detail study about nc886′s impact on gene expression and cellular phenotypes. Here we have shown that nc886 inhibits AKT, a key protein in a renowned pro-survival p...
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#1Ju Mi Lee (Hallym University)H-Index: 1
#2Kongara Damodar (Hallym University)H-Index: 16
Last. Jeong Tae Lee (Hallym University)H-Index: 13
view all 7 authors...
Source
#1Ju Mi Lee (Hallym University)H-Index: 1
#2Kongara Damodar (Hallym University)H-Index: 16
Last. Jeong Tae Lee (Hallym University)H-Index: 13
view all 6 authors...
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