Zhiyong Wang
Renmin University of China
GeneCancerInternal medicineGenomeSingle-nucleotide polymorphismMolecular biologyNanoparticleComposite materialTranscriptomeFullereneNanotechnologyChemistryComplementary DNAMaterials scienceLarimichthys croceaChemical engineeringCancer researchCarbon nanotubeGeneticsMedicinePI3K/AKT/mTOR pathwayBiology
Publications 337
#7Zhiyong Wang (JMU: Jimei University)H-Index: 24
Abstract null null Yellow drum (Nibea albiflora), a commercially important fish species in the coastal regions of southeast China, suffers greatly from attacks from bacteria, viruses, and parasites. To uncover their immune responses, the yellow drums were artificially challenged with the pathogenic Vibrio harveyi, and genome-wide association study (GWAS) was performed to identify the associated SNPs and genetic loci for disease resistance trait. Sequence analysis in 197 susceptible and 148 resis...
1 CitationsSource
#1Baolan Wu (JMU: Jimei University)
#2Qing Song (NUPT: Nanjing University of Posts and Telecommunications)H-Index: 10
Last. Fang Han (JMU: Jimei University)H-Index: 5
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Abstract null null Galectins are protein that participates in a variety of immune responses in the process of pathogenic infections. In the present study, a chimera galectin gene was screened from the transcriptome database of Nibea albiflora, which was named as YdGal-3. The results of qRT-PCR showed that the mRNA transcripts of YdGal-3 were ubiquitously distributed in all the detected tissues. After infection with Vibrio harveyi, the expression of YdGal-3 in liver, spleen, and head kidney incre...
#1J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
#2Alfredo A. Molinolo (UCSD: University of California, San Diego)H-Index: 73
Last. Denise M. Laronde (UBC: University of British Columbia)H-Index: 9
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BACKGROUND The aberrant activation of the PI3K/mTOR signaling circuitry is one of the most frequently dysregulated signaling events in head and neck squamous cell carcinoma (HNSCC). Here, we conducted a single-arm, open label phase IIa clinical trial (NCT02581137) in individuals with oral premalignant lesions (OPL) to explore the potential of metformin to target PI3K/mTOR signaling for HNSCC prevention. METHODS Subjects with OPL, otherwise healthy and without diabetes, underwent pre- and post-tr...
#1Zhiyong Wang (Liaoning Technical University)H-Index: 24
Last. Xi Chen (Wenzhou University)
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Pantograph-catenary system is a key component of high-speed railway. Under high speed and strong current operation conditions, the surface roughness of the sliding electrical contact between contact wire and slide changes continuously. It will cause the fluctuation of contact resistance and lower the electrical contact property of the system. Therefore, it is of great significance to study the relationships between the contact resistance and surface roughness characteristics. In this paper, lots...
#1Mara Gilardi (University Hospital of Basel)H-Index: 1
#2Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 16
Last. Haruka Miki (La Jolla Institute for Allergy and Immunology)H-Index: 3
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Head and neck squamous cell carcinoma (HNSCC) ranks 6th in cancer incidence worldwide and has a five-year survival rate of only 63%. Despite advances in curative-intent therapies over the past three decades, rates of recurrence exceed 50% and long-term toxicities remain unacceptably morbid. Immunotherapies - principally immune checkpoint inhibitors (ICI) such as αPD-1 and αCTLA-41 antibodies which restore endogenous antitumor T cell immunity - offer the greatest promise for achieving durable res...
#1Kongjia Zheng (RUC: Renmin University of China)
#2Jianjun Deng (RUC: Renmin University of China)
Last. Zhihai Cheng (RUC: Renmin University of China)
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Ultrathin two-dimensional transition metal dichalcogenides represent a promising new class of materials with surface-enhanced Raman scattering (SERS) activities. Previous work mainly focused on the...
#1Hongxin GaoH-Index: 2
#2Zhiyong Wang (Liaoning Technical University)H-Index: 24
Last. Baifu Li
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#1Li He (JGSU: Jinggangshan University)
#2Li Teng (Haida: Hainan University)
Last. Li Liao (Haida: Hainan University)
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Axonopus compressus also known as carpet grass is a robust, stoloniferous grass that can grow in minimal fertilization and resists well to abiotic and biotic stresses including low nitrogen (LN) stress. This study aimed at characterizing the agro-morphological and metabolome responses to LN in carpet grass leaves. Under LN stress, carpet grass increased yellowness of leaves and root dry matter while reduced turf quality and shoot dry weight. The metabolome comparison between samples from optimum...
#1Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 24
#2Yusuke Goto (UCSD: University of California, San Diego)H-Index: 5
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
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Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but <20% of patients achieve durable responses. Persistent activation of the PI3K/AKT/mTOR signaling circuitry represents a key oncogenic driver in HNSCC; however, the potential immunosuppressive effects of PI3K/AKT/mTOR inhibitors may limit the benefit of their combination with ICB. Here we employ an unbiased kinome-wide siRNA screen to reveal that HER3, is essential for the prol...
How to realize applicably appreciated functionalities based on the coupling between charge and spin degrees of freedom is still a challenge in the field of spintronics. For example, anisotropic magnetoresistance (AMR) effect is utilized to read out the information stored by various magnetic structures, which usually originates from atomic spin-orbit coupling (SOC). However, the application of AMR in antiferromagnet-based spintronics is still hindered by rather small AMR value. Here, we discover ...