Farhin Patel
Charotar University of Science and Technology
Mode of actionInternal medicineEndocrinologyUnfolded protein responseGlycationWhite adipose tissueProinflammatory cytokineNeuroscienceAdipose tissueAdipose tissue macrophagesTumor necrosis factor alphaChemistryAdipokineImmunologyIn vivoTLR4Oxidative stressAdipocyteLiver injuryMacrophage polarizationInflammationAlcoholic liver diseaseMalondialdehydeMethylglyoxalLipopolysaccharideDiabetic nephropathyKidneyProbioticMetforminAlcoholBrain developmentRat kidneyMolecular mechanismPhysiologyLipid metabolismGut floraNervous systemMedicineEpithelial–mesenchymal transitionBiologyPharmacology
8Publications
2H-index
7Citations
Publications 10
Newest
#1Kirti Parwani (Charotar University of Science and Technology)H-Index: 3
#2Farhin Patel (Charotar University of Science and Technology)H-Index: 2
Last. Palash Mandal (Charotar University of Science and Technology)H-Index: 13
view all 7 authors...
Context null The molecular mechanism by which Swertiamarin (SM) prevents advanced glycation end products (AGEs) induced diabetic nephropathy (DN) has never been explored. null Objective null To evaluate the effect of SM in preventing the progression of DN in high fat diet-streptozotocin-induced diabetic rats. null Materials and methods null After 1 week of acclimatisation, the rats were divided randomly into five groups as follows: (1) Control group, which received normal chow diet; (2) High-fat...
Source
#1Farhin Patel (Charotar University of Science and Technology)H-Index: 2
#2Kirti Parwani (Charotar University of Science and Technology)H-Index: 3
Last. Palash Mandal (Charotar University of Science and Technology)H-Index: 13
view all 6 authors...
Ethanol depletes intestinal integrity and promotes gut dysbiosis. Studies have suggested the individual role of probiotics and metformin Met in protecting intestinal barrier function from injuries induced by ethanol. The objective of the current study is to investigate the potential mechanism by which coadministration of probiotic Visbiome® (V) and Met blocks the ethanol-induced intestinal barrier dysfunction/gut leakiness utilizing Caco-2 monolayers, a rat model with chronic ethanol injury, and...
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#1Kirti ParwaniH-Index: 3
#2Farhin PatelH-Index: 2
Last. Palash MandalH-Index: 13
view all 4 authors...
Increased blood glucose in diabetic individuals results in the formation of advanced glycation end products (AGEs), causing various adverse effects on kidney cells, thereby leading to diabetic nephropathy (DN). In this study, the antiglycative potential of Swertiamarin (SM) isolated from the methanolic extract of E. littorale was explored. The effect of SM on protein glycation was studied by incubating bovine serum albumin with fructose at 60 °C in the presence and absence of different concentra...
Source
#1Farhin Patel (Charotar University of Science and Technology)H-Index: 2
#2Kirti Parwani (Charotar University of Science and Technology)H-Index: 3
Last. Palash Mandal (Charotar University of Science and Technology)H-Index: 13
view all 4 authors...
Alcohol-induced liver injury implicates inflammation and oxidative stress as important mediators. Despite rigorous research, there is still no Food and Drug Administration (FDA) approved therapies for any stage of alcoholic liver disease (ALD). Interestingly, metformin (Met) and several probiotic strains possess the potential of inhibiting alcoholic liver injury. Therefore, we investigated the effectiveness of combination therapy using a mixture of eight strains of lactic acid-producing bacteria...
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#1Kirti ParwaniH-Index: 3
#2Farhin PatelH-Index: 2
Last. Palash MandalH-Index: 13
view all 4 authors...
Source
#1Farhin PatelH-Index: 2
#2Palash MandalH-Index: 13
Source
#1Farhin PatelH-Index: 2
#2Palash MandalH-Index: 13
Source
#1Farhin PatelH-Index: 2
#2Palash MandalH-Index: 13
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#1Dhara PatelH-Index: 9
#2Farhin PatelH-Index: 2
Last. Palash MH-Index: 1
view all 3 authors...
Alcohol consumption and its abuse are significant prevalent cause for liver diseases and death worldwide. Increased bacterial endotoxin in the portal circulation, the plasma ratio of liver enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride implies the symbiotic relation between the gut and liver plays a key function in alcoholic liver disease (ALD). Consumption of alcohol leads to gut dysbiosis and informalities of the intestinal barrier, hyper gut per...
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#1Venkata Harini Kema (BITS: Birla Institute of Technology and Science)H-Index: 2
#2Imran Khan (BITS: Birla Institute of Technology and Science)H-Index: 5
Last. Palash Mandal (Charotar University of Science and Technology)H-Index: 13
view all 10 authors...
Background Alcohol consumption is the fourth leading cause of death and disability worldwide. Several cellular pathways contribute to alcohol-mediated tissue injury. Adipose tissue apart from functioning as an endocrine organ secretes several hormones and cytokines known as adipokines that are known to play a significant role in alcohol-induced tissue damage. This study was designed to test the efficacy of diallyl sulfide (DAS) in regulating the alcohol-induced outcomes on adipose tissue. Method...
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