Sijia Sun
University of Toyama
CytotoxicityCell migrationCellCytotoxic T cellAcid hydrolysisChemistryApoptosisPhytochemicalAutophagyTumor microenvironmentHeLaAnneslea fragransPancreatic cancerCell morphologyPancreatic cancer cellProgrammed cell deathCancer researchBiochemistryStereochemistryProtein kinase BPI3K/AKT/mTOR pathwayCancer cell
24Publications
5H-index
91Citations
Publications 25
Newest
#1Sijia SunH-Index: 5
#2Min Jo KimH-Index: 4
Last. Suresh AwaleH-Index: 38
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#1Sijia Sun (University of Toyama)H-Index: 5
#2Min Jo Kim (University of Toyama)H-Index: 4
Last. Suresh Awale (University of Toyama)H-Index: 38
view all 6 authors...
Pancreatic tumors are hypovascular, which leads to a poor nutrient supply to support the aggressively proliferating tumor cells. However, human pancreatic cancer cells have extreme resistance to nutrition starvation, which enables them to survive under severe metabolic stress conditions within the tumor microenvironment, a phenomenon known as "austerity" in cancer biology. Discovering agents which can preferentially inhibit the cancer cells' ability to tolerate starvation conditions represent a ...
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#1Sijia Sun (University of Toyama)H-Index: 5
#2Ashraf M. Omar (University of Toyama)H-Index: 3
Last. Suresh Awale (University of Toyama)H-Index: 38
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Abstract A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circu...
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#1Juthamart Maneenet (University of Toyama)
#1Juthamart Maneenet (University of Toyama)
Last. Suresh Awale (University of Toyama)H-Index: 38
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Ethanolic extract of Nelumbo nucifera petals showed preferential cytotoxic activity against HeLa human cervical cancer cell line with a PC50 value of 10.4 μg/mL. This active extract was subjected to a phytochemical investigation study which led to the isolation of nine benzylisoquinoline alkaloids (1-9). The isolated compounds exhibited potent antiausterity activities. Moreover, under nutrient-deprived conditions, (-)-lirinidine (8) induced remarkable alterations in HeLa cell morphology includin...
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#1Ashraf M. Omar (University of Toyama)H-Index: 3
#2Sijia Sun (University of Toyama)H-Index: 5
Last. Suresh Awale (University of Toyama)H-Index: 38
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The antiausterity strategy is a promising approach for the discovery of lead compounds with unprecedented anticancer activities by targeting the tolerance of cancer cells to nutrition starvation. These agents are selectively cytotoxic under the tumor microenvironment-mimicking condition of nutrition starvation, without apparent toxicity in the normal nutrient-rich condition. In this study, an ethanol extract of Betula alnoides showed antiausterity activity against PANC-1 human pancreatic cancer ...
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#1Sijia SunH-Index: 5
#2Dya Fita DibweH-Index: 12
Last. Suresh AwaleH-Index: 38
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Abstract An ethanolic extract of Derris scandens flowers showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived condition, with a PC50 value of 0.7 μg/mL. Phytochemical investigation of this active extract led to the isolation of four prenylated isoflavones (1–4) including a new compound named 4′-O-methylgrynullarin (1). The structure elucidation of the new compound was achieved by HRFABMS and NMR spectroscopic analysis. The isolated compound...
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#1Sijia Sun (University of Toyama)H-Index: 5
#2Min Jo Kim (University of Toyama)H-Index: 4
Last. Suresh Awale (University of Toyama)H-Index: 38
view all 10 authors...
Human pancreatic tumor cells have an intrinsic ability to tolerate nutrition starvation and survive in the hypovascular tumor microenvironment, the phenomenon termed as “austerity”. Searching for an agent that inhibits such tolerance to nutrient starvation and kills the pancreatic cancer cells preferentially in nutrient-starvation is a unique anti-austerity strategy in anti-cancer drug discovery. In this strategy, plant extracts and compounds are tested against PANC-1 human pancreatic cancer cel...
1 CitationsSource
#1Shaimaa Fayez (University of Würzburg)H-Index: 5
#2Alessia Cacciatore (University of Würzburg)
Last. Gerhard Bringmann (University of Würzburg)H-Index: 76
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Abstract From the leaves of Ancistrocladus abbreviatus (Ancistrocladaceae), six 5,1'-coupled naphthyldihydroisoquinoline alkaloids were isolated, ancistrobrevidines A-C (5-7), 5-epi-dioncophyllidine C2 (10), 6-O-methylhamatinine (8), and 6-O-methylancistectorine A3 (9); the two latter compounds were already known from related plants. Most strikingly, this series comprises alkaloids belonging to three different subclasses of naphthylisoquinolines. Ancistrobrevidine C (7) and the alkaloids 8 and 9...
1 CitationsSource
#1Ashraf M. Omar (University of Toyama)H-Index: 3
#2Sijia Sun (University of Toyama)H-Index: 5
Last. Suresh Awale (University of Toyama)H-Index: 38
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Abstract Phytochemical investigation of the ethanolic extract of Anneslea fragrans twigs resulted the isolation of two new highly-oxygenated and sterically hindered spiro-biflavanoids, named fragranols B and C (1 and 2), together with a known compound 3-epilarixinol (3). The structural elucidation was achieved by HRFABMS, NMR spectroscopic analysis, and quantum ECD calculations. A plausible biogenetic pathway of the isolated compounds is also proposed.
1 CitationsSource
#1Phu Hoang Dang (VNUHCM: Vietnam National University, Ho Chi Minh City)H-Index: 12
#2Thien H. X. Dao (VNUHCM: Vietnam National University, Ho Chi Minh City)
Last. Nhan Trung Nguyen (VNUHCM: Vietnam National University, Ho Chi Minh City)H-Index: 19
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