Fei Han
Shenyang Pharmaceutical University
PharmacokineticsAnalytical chemistryMass spectrometryFourier transform ion cyclotron resonanceHigh-performance liquid chromatographyChemistryDecoctionMetabolic pathwayIon cyclotron resonanceGlycosideTransdermalIn vivoMetabolomicsOral administrationDrug deliveryGlucuronidationDrugFlurbiprofenRhodiola crenulataChemical constituentsFt icr msElectrospray ionizationChromatographyMetabolismMedicinePharmacology
51Publications
17H-index
712Citations
Publications 49
Newest
#1Wei Sun (SPU: Shenyang Pharmaceutical University)
Last. Fei Han (SPU: Shenyang Pharmaceutical University)H-Index: 17
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Rationale Alzheimer's disease (AD) is a chronic, severe, progressive neurodegenerative disorder associated with cognitive and memory impairment, and it ultimately causes death. Most approved drugs can only alleviate some of the symptoms of AD, but no interventions have been found that reverse the underlying disease mechanisms. Rhodiola crenulata extract (RCE) has been reported to alleviate AD symptoms in rats. However, its underlying mechanism of action is still unclear. Methods A brain lipidomi...
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#1Lu Xu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Yu Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 26
Last. Fei Han (SPU: Shenyang Pharmaceutical University)H-Index: 17
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RATIONALE Recently, isotopic fine structures derived from Fourier transform ion cyclotron resonance mass spectrometry have been used to determine the molecular formula for unknown compounds in many complex systems. However, a simplified strategy for molecular formula determination of chemical constituents in traditional Chinese medicines (TCMs) based on accurate mass, A+1 and A+2 isotopic peaks is necessary. METHODS Salviae miltiorrhizae was selected as the representative species. First, the che...
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#1Yanan Wang (SPU: Shenyang Pharmaceutical University)
#1Wang Yanan (SPU: Shenyang Pharmaceutical University)
Last. Han Fei (SPU: Shenyang Pharmaceutical University)
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OBJECTIVE To explore the mechanism of Flos Puerariae and Semen Hoveniae in treatment of alcoholic liver injury (ALI) based on network pharmacology and molecular docking. METHODS The information of chemical constituents and targets of Flos Puerariae and Semen Hoveniae was collected from TCMSP and Swiss databases, and the threshold values of oral bioavailability (OB) ≥ 30%, drug likeness (DL) ≥0.18 were used to screen the potential active compounds. The GeneCard and DrugBank databases were used to...
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#1Yiqiang Yue (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Jiahong Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Fei Han (SPU: Shenyang Pharmaceutical University)H-Index: 17
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Abstract Profiling impurities for the active pharmaceutical ingredients (APIs) is an indispensable step in drug development process. Nowadays, high resolution mass spectrometry is the first choice for determining the chemical formula of organic impurities. However, merely base on the accurate mass to screen the formula is obviously not a flawless method. In this paper, a reliable strategy based on Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) was presented to profile th...
1 CitationsSource
Abstract Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder. Rhodiola crenulata extract (RCE) has shown its protective effects on AD, however, the underlying mechanism is still unclear. In this work, serum lipidomics was conducted to reveal the action mechanism of RCE on AD by HPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). The animal model of AD was reproduced by intrahippocampal injection of Aβ1-42 in rats. The novel obje...
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#1Xintong Li (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Yanan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Fei Han (SPU: Shenyang Pharmaceutical University)H-Index: 17
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In order to investigate the protective effects of Rhodiola crenulata extract on Alzheimer's disease, a brain metabolomics study in rats was conducted by HPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry. Rat model was constructed by bilateral hippocampal injection of amyloid-β peptide and immunohistochemistry was performed to evaluate the pharmacological effect of Rhodiola crenulata extract. Multivariate statistical analysis was used to discover potential biomarkers i...
1 CitationsSource
#1Lu XuH-Index: 1
#2Yu ZhangH-Index: 26
Last. Fei HanH-Index: 17
view all 8 authors...
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#1Yue Cui (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Huanhuan Yang (SPU: Shenyang Pharmaceutical University)
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Gansuibanxia decoction (GSBXD) is one of the most famous traditional Chinese medicine (TCM). It is a herbal formula used for treating hydrops, such as cancerous ascites, pleural effusion, pericardial effusion, etc. However, the chemical constituents of GSBXD were still unclear. In this study, an UHPLC-FT-ICR-MS method was established and applied to the separation and characterization of the chemical constituents of GSBXD. A total of 62 components were chemically defined or tentatively i...
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#1Lu Xu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Xintong Li (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Fei Han (SPU: Shenyang Pharmaceutical University)H-Index: 17
view all 5 authors...
RATIONALE: In the process of identification of unknown metabolites, the most important thing is to determine their real chemical formulae according to the accurate mass which were detected by high-resolution mass spectrometry (HRMS). However, high mass accuracy alone is not enough to exclude false candidates. Use of isotopic fine structures (IFSs) derived from FT-ICR MS as a single further constraint could decisively determine the molecular formula for unknown metabolites. METHODS: Gastrodin, an...
1 CitationsSource
#1Yue Cui (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Roujia Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Gansui-Gancao is one of the “eighteen incompatible herb pairs” which was recorded 2000 years ago according to TCM (Traditional Chinese Medicine) theory for their toxicity when using together. Nevertheless, Gansuibanxia decoction contained the herb pair have satisfactory effect on the treatment of cancerous ascites, pericardial effusion, etc. The present study aimed to investigate the mechanism of the incompatibility of Gansui-Gancao and the compatibility of Gansuibanxia decoction using ...
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