Dana Akilbekova
Iowa State University
Self-healing hydrogelsIrradiationBiophysicsBiomedical engineeringMicroscopyComposite materialRegeneration (biology)Hydrogen sulfide sensorCompression (physics)ChemistryMaterials sciencePlastic optical fiberFiber optic sensorVascular endothelial growth factorArginineFlashlightCytokineWound healingPlastic fiberElastic modulusOptoelectronicsTissue engineeringMedicinePlasticityBiologyDetectorCancer cell
16Publications
8H-index
143Citations
Publications 15
Newest
#1Anuraag Boddupalli (Iowa State University)H-Index: 4
#2Dana Akilbekova (Iowa State University)H-Index: 8
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
view all 3 authors...
Abstract Functionalized biomaterials interface with tissue upon implantation. There is a growing need to understand how materials properties influence this interaction so that efficient tissue engineering systems can be developed. In this study, we characterize collagen organization in response to functionalized glass beads implanted in SKH1-E mice. Poly- l -arginine (PLR) was modified with arginine derivatives to create a functionalized surface and was coated on glass beads. Tissue sections wer...
2 CitationsSource
#1Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
#2Vyacheslav OgayH-Index: 13
Last. Zhandos Utegulov (NU: Nazarbayev University)H-Index: 10
view all 9 authors...
Biomechanical properties of mammalian bones, such as strength, toughness, and plasticity, are essential for understanding how microscopic-scale mechanical features can link to macroscale bones’ strength and fracture resistance. We employ Brillouin light scattering (BLS) microspectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins, and osteog...
18 CitationsSource
#1Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
#2Madina Shaimerdenova (NU: Nazarbayev University)H-Index: 8
Last. Dmitriy Berillo (University of Brighton)H-Index: 13
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Abstract The chitosan and gelatine are commonly used biopolymers for the tissue engineering applications. In the previous methods for the cryogels synthesis, multistep preparation methods using toxic cross-linking agents such as glutaraldehyde are reported. Here, we present a two-step preparation method of gelatin macroporous cryogels and one-step preparation method of chitosan or gelatin cryogels. The physico-chemical properties of obtained scaffolds were characterized using FTIR, zeta potentia...
29 CitationsSource
#1Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
#2Anuraag Boddupalli (Iowa State University)H-Index: 4
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
view all 3 authors...
Recent studies have demonstrated the beneficial effect of low-power lasers and polarized light on wound healing, inflammation, and the treatment of rheumatologic and neurologic disorders. The overall effect of laser irradiation treatment is still controversial due to the lack of studies on the biochemical mechanisms and the optimal parameters for the incident light that should be chosen for particular applications. Here, we study how NIH/3T3 fibroblasts respond to irradiation with linearly polar...
1 CitationsSource
#1Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
#2Talgat Yakupov (NU: Nazarbayev University)H-Index: 2
Last. Zhandos Utegulov (NU: Nazarbayev University)H-Index: 10
view all 6 authors...
Biomechanical properties of mammalian bones, such as strength, toughness and plasticity, are essential for understanding how microscopic scale mechanical features can link to macroscale bones’ strength and fracture resistance. We employ Brillouin light scattering (BLS) micro-spectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins (BMPs) and ...
2 CitationsSource
Last. Kanat DukenbayevH-Index: 11
view all 7 authors...
Source
#1Arman Aitkulov (NU: Nazarbayev University)H-Index: 3
#2Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
Last. Massimo Olivero (Polytechnic University of Turin)H-Index: 12
view all 4 authors...
We propose a method to design a hydrogen sulfide (H 2 S) sensor system, consisting of a plastic optical fiber (POF) and smartphone. The sensor employs the chemical reaction of sulfide gas with silver deposited on the POF. In the proposed design, the sensor is remotely located from the phone, while we use its flashlight as a light source and camera as a pixel-based detector. Moreover, a custom fiber connector socket, fabricated with a 3D printer, is used to couple light to and from the POF. a mob...
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#1Alimzhan Sultangazin (NU: Nazarbayev University)H-Index: 1
#2Janysbek Kusmangaliyev (NU: Nazarbayev University)H-Index: 1
Last. Daniele Tosi (NU: Nazarbayev University)H-Index: 26
view all 6 authors...
We present a low-cost, handheld plastic optical fiber (POF) sensor for hydrogen sulfide (H2S) detection integrated onto a smartphone. The sensor uses smartphone flashlight as a source and camera as a pixel-based intensity detector. The POF is interconnected to the smartphone with a 3-D-printed connector on both source/detector sides. The sensing mechanism is embedded in the fiber link, making the system an all-fiber smartphone architecture. A mobile application handles data acquisition on the An...
12 CitationsSource
#1Madina Shaimerdenova (NU: Nazarbayev University)H-Index: 8
#2Orynbassar Karapina (NU: Nazarbayev University)H-Index: 1
Last. Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
view all 5 authors...
Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on morphometric and migratory features of the MCF7 breast cancer cell line. Molecular levels of various proteins have also been examined. To evaluate and assess the effect of antiviral treatmen...
13 CitationsSource
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