Lisa Molls
RWTH Aachen University
Matrix metalloproteinaseEndothelial stem cellDownregulation and upregulationChemokineGene knockdownTumor necrosis factor alphaChemistryTHP1 cell lineShear stressGrowth factorEndotheliumKLF2Geranylgeranyl pyrophosphateCX3CR1AdhesionCell adhesionBiologyCell biology
2Publications
2H-index
17Citations
Publications 2
Newest
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 9
#2Lisa Molls (RWTH Aachen University)H-Index: 2
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 57
view all 11 authors...
Abstract Reduced shear stress resulting from disturbed blood flow can impair endothelial integrity and drive the development of vascular inflammatory lesions. Metalloproteinases of the ADAM family have been implicated in the regulation of cell survival and inflammatory responses. Here we investigate the mechanism and function of ADAM15 upregulation in primary flow cultured endothelial cells. Transcriptomic analysis indicated that within the ADAM family ADAM15 mRNA is most prominently upregulated...
Source
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 9
#2Lisa Molls (RWTH Aachen University)H-Index: 2
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 57
view all 5 authors...
Flow conditions critically regulate endothelial cell functions in the vasculature. Reduced shear stress resulting from disturbed blood flow can drive the development of vascular inflammatory lesions. On endothelial cells, the transmembrane chemokine CX3CL1/fractalkine promotes vascular inflammation by functioning as a surface-expressed adhesion molecule and by becoming released as soluble chemoattractant for monocytic cells expressing the receptor CX3CR1. Here, we report that endothelial cells f...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.