R. von Kummer
Dresden University of Technology
Internal medicineRadiologySurgeryPathologyCerebral blood flowCardiologyRandomized controlled trialMiddle cerebral arteryOcclusionVascular diseaseInfarctionCerebral angiographyCentral nervous system diseaseCerebral infarctionThrombolysisNeuroradiologyAngiographyNuclear medicineAcute strokeAnesthesiaStrokeIschemiaMedicine
Publications 101
#1Uta Meyding-Lamadé (Heidelberg University)H-Index: 25
#2Christian JacobiH-Index: 13
Last. R. von Kummer (TUD: Dresden University of Technology)H-Index: 30
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Introduction Comprehensive treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major clinical challenge. The current therapy gold standard is aciclovir, a drug that inhibits viral replication. Despite antiviral treatment, mortality remains around 20% and a majority of survivors suffer from severe disability. Experimental research and recent retrospective clinical observations suggest a favourable therapy response to adjuvant dexamethasone. Currently there is no randomized clinical tr...
6 CitationsSource
#1Werner HackeH-Index: 137
#2Patrick D. LydenH-Index: 88
Last. K.R. LeesH-Index: 6
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Summary Background The REVASCAT trial and other studies have shown that the neurovascular thrombectomy improves outcomes at 90 days post stroke. However, whether the observed benefit is sustained in the long term remains unknown. We report the results of the prespecified 12-month analysis of the REVASCAT trial. Methods Patients with acute ischaemic stroke who could be treated within 8 h of symptom onset were randomly assigned to medical therapy (including intravenous alteplase when eligible) and...
42 CitationsSource
#1Thomas A. Tomsick (University of Cincinnati Academic Health Center)H-Index: 71
#2Janice Carrozzella (University of Cincinnati Academic Health Center)H-Index: 22
Last. David S LiebeskindH-Index: 84
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BACKGROUND AND PURPOSE: Uncertainty persists regarding the safety and efficacy of endovascular therapy of M2 occlusions following IV tPA. We reviewed the impact of revascularization on clinical outcomes in 83 patients with M2 occlusions in the Interventional Management of Stroke III trial according to specific M1-M2 segment anatomic features. MATERIALS AND METHODS: Perfusion of any M2 branch distinguished M2-versus-M1 occlusion. Prespecified modified TICI and arterial occlusive lesion revascular...
22 CitationsSource
#1R. von Kummer (TUD: Dresden University of Technology)H-Index: 30
#2J Mocco (Mount Sinai Health System)H-Index: 10
Last. Albert J YooH-Index: 52
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Introduction Limited data exist on the efficacy of intra-arterial therapy (IAT) for ischemic stroke resulting from extended thrombi. IV-rtPA has been the staple of ischemic stroke therapy, however the efficacy of IV thrombolytics is known to diminish with increasing thrombus length, subsequently reducing the potential for successful revascularization. For increasing thrombus lengths, the benefits of aspiration thrombectomy have yet to be validated in a large, randomized trial, but may offer adva...
#1Osama O. Zaidat (Mercy Medical Center (Baltimore, Maryland))H-Index: 62
#2Brijesh P MehtaH-Index: 14
Last. J Mocco (Mount Sinai Health System)H-Index: 10
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Introduction Imaging still serves as an integral tool for stroke validation and intervention. Limited data is available as to whether performing CTA immediately following non-contrast CT (NCCT) will delay overall treatment time. Centers conducting concurrent NCCT and CTA relative to those performing NCCT alone were evaluated to determine whether having additional imaging extends hospital workflow, prolonging time to IV rtPA and subsequently to endovascular intervention, where warranted. Material...
1 CitationsSource
#1R. von Kummer (TUD: Dresden University of Technology)H-Index: 30
#2Donald FreiH-Index: 26
Last. J Mocco (Mount Sinai Health System)H-Index: 10
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Introduction There is currently no standardized criterion for a clinically defined symptomatic intracranial hemorrhages (sICH), particularly secondary to endovascular therapy of ischemic stroke. Recent randomized controlled trials evaluating the efficacy and safety of intra-arterial therapy have published results with varying complication rates based upon the sICH definition employed. To further elucidate the variability in sICH outcome, the present study subjects the THERAPY cohort to definitio...
#1Guy Wilms (Katholieke Universiteit Leuven)H-Index: 41
#2R. von KummerH-Index: 30
Last. Majda M. ThurnherH-Index: 29
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Background and Purpose— A progressive decline in the odds of favorable outcome as time to reperfusion increases is well known. However, the impact of specific workflow intervals is not clear. Methods— We studied the mechanical thrombectomy group (n=103) of the prospective, randomized REVASCAT (Randomized Trial of Revascularization With Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours ...
77 CitationsSource
#1P. Aulbach (TUD: Dresden University of Technology)H-Index: 1
#2D. MuchaH-Index: 4
Last. R. von Kummer (TUD: Dresden University of Technology)H-Index: 30
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BACKGROUND AND PURPOSE: Detection and evaluation of ruptured aneurysms is critical for choosing an appropriate endovascular or neurosurgical intervention. Our aim was to assess whether bone-subtraction CTA is capable of guiding treatment for cerebral aneurysms in patients with acute SAH and could replace DSA. MATERIALS AND METHODS: We prospectively studied 116 consecutive patients with SAH with 16–detector row bone-subtraction CTA and DSA before intracranial aneurysm treatment. Two independent n...
5 CitationsSource