Yu Zhao
Nantong University
CytotoxicityTopoisomeraseMolecular biologyCytotoxic T cellChemistryApoptosisGlycosideIn vitroWestern blotHeLaPodophyllotoxinAcridine orangeMTT assayLignanCleistanthinCancer cell linesDNABiochemistryStereochemistryBiologyCancer cell
21Publications
11H-index
255Citations
Publications 19
Newest
#1Yu Zhao (Nantong University)H-Index: 11
#2Yuejiao Cao (Nantong University)H-Index: 2
Last. Xiaorong Zhou (Nantong University)H-Index: 5
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Loss of the B2M gene is associated with tumor immune escape and resistance to immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer (NSCLC) patients and found that epigenetic downregulation of B2M is common. B2M-low tumors exhibit a suppressive immune microenvironment characterized by reduced infiltration of immune cells of various lineages; in B2M-hi...
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#1Mangze Hu (Nantong University)H-Index: 1
#2Yu Zhao (Nantong University)H-Index: 11
Last. Xiaorong Zhou (Nantong University)H-Index: 1
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Metabolic alterations are well documented in various cancers. Non-small cell lung cancers (NSCLCs) preferentially use lactate as the primary carbon source, but the underlying mechanisms are not well understood. We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramm...
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#1Hua Ni (Nantong University)H-Index: 1
#2Chao Xia (Nantong University)H-Index: 1
Last. Yu Zhao (Nantong University)H-Index: 11
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Mansouramycins are newly isolated cytotoxic isoquinoline quinones from marine organism. To find novel anticancer agents, eighteen isoquinoline quinones 7a–7r as Mansouramycins analogs were designed and synthesized. Most of these compounds displayed moderate cytotoxicities against MCF-7, A549, HCT116, and HepG2 cancer cell lines at micromolar concentration. Compound 7a was found to has the ability of inducing HepG2 cells apoptosis by Hoechst33342 staining assay.
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#1Ying Wang (Nantong University)H-Index: 1
#2Chao Xia (Nantong University)H-Index: 1
Last. Yu Zhao (Nantong University)H-Index: 11
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Novel lignan glycosides 1a-1 h as analogues of cleistanthin A were designed and synthesized. Most of these compounds displayed significant cytotoxicities against four cancer cell lines. Compound 1e displayed better cytotoxicity than cleistanthin A with IC50 values from 1.0 nm to 8.3 nm. Further lysosome acidity assay disclosed that 1e could totally inhibit the activity of V-ATPase at 60 nm.
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#1Yapeng Lu (Jiangsu University)H-Index: 3
#2Rui ZhangH-Index: 2
Last. Li Zhu (Nantong University)H-Index: 23
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The vacuolar H+-ATPase (V-ATPase) has recently been proposed as a key target for new strategies in cancer treatment. Our previous work has proved that diphyllin glycoside is a novel inhibitor of V-ATPase. Here the cytotoxic effects of ZT-25, the most potent diphyllin glycoside derivatives, were studied and some of the underlying mechanisms were elucidated. ZT-25 displayed strong cytotoxicity on several cancer cell lines and relatively low cytotoxicity on human fetal hepatic cells (WRL-68) at sub...
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#1Yu Zhao (Nantong University)H-Index: 11
#2Yapeng Lu (Nantong University)H-Index: 9
Last. Li Zhu (Nantong University)H-Index: 13
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Twelve new glycosides and alkane derivatives of cleistanthin A were designed and synthesized. Their in vitro antiproliferative activity was investigated against HCT-116, HepG2, A549, Hela tumor cell lines and HEK293 cell by MTT assay. Most of these compounds displayed antiproliferative effects on four cancer cells at submicromolar concentration, but they were less potent than cleistanthin A Moreover, they showed no antiproliferative effects on HEK293 cell at 200 nm. The most potent compounds, 3e...
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#1Yu Zhao (Nantong University)H-Index: 11
#2Rui Zhang (Nantong University)H-Index: 2
Last. Li Zhu (Nantong University)H-Index: 13
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Abstract The vacuolar H + -ATPase (V-ATPase) was proposed as a key target for new strategies in cancer treatment recently. We have synthesized a novel class of derivatives of Cleistanthin-A bearing heterocyclic moieties. Most of these compounds displayed potent antiproliferative effects on four cancer cells at submicromolar concentration, and they have no cytotoxicity on normal WRL-68 cells at 200 nM. The most potent compound 3a has been shown to inhibit the activity of vacuolar H + -ATPase at s...
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#1Zhitao Zhang (Nantong University)H-Index: 3
#2Jinlong Ma (Nantong University)H-Index: 3
Last. Yu Zhao (Nantong University)H-Index: 11
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Abstract The concise syntheses of two natural diphyllin glycosides Cleistanthin-A ( CA ), Cleistanthoside-A ( CleA ) and its derivative, Cleistanthoside-A tetraacetate ( CleT ), have been achieved. They were evaluated for their in vitro anti-proliferative activities against MCF-7, HeLa, HepG2, HCT-116, U251 cancer cell lines by MTT assay. Both of CA and CleT were anti-proliferative to these cancer cells at nanomolar concentrations. They have been shown to inhibit the activity of vacuolar H + -AT...
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#1Xiaodong Zhao (ZJOU: Zhejiang Ocean University)H-Index: 1
#2Qiu Tan (Nantong University)H-Index: 2
Last. Yu Zhao (Nantong University)H-Index: 11
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A series of 1,3,5-triazine-based hydroximic acids 6a–6i were designed and synthesized, and they were found to be potent inhibitors of human histone deacetylases. These compounds were evaluated for their antiproliferative activity by MTT assay, and most of them exhibited significant antiproliferative effect on HCT-116, MCF-7, and HeLa cancer cell lines. DNA flow cytometric analysis revealed that compound 6i induced apoptosis and cell cycle arrest at G2/M phase in HCT-116 cells.
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#1Yapeng LuH-Index: 3
#2Siyuan LiuH-Index: 4
Last. Shuqin YuH-Index: 1
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an provinces of China, has been used for a long time as a traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases (1, 2) as well as a common food supplement to reinforce vital energy (3, 4). Modern phytochemical studies have shown that LIG (Fig. 1) is the main lipophilic component of Danggui (1). Our previous studies have shown that LIG had neuroprotective effects on some models of diseases associated with cerebral ischemia. Treatment with LIG could significantly improv...
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