Haiyan Sun
Chinese Academy of Sciences
VacuoleCentrosomeCancerMembrane proteinPLK1CellCell signalingNotch signaling pathwayCathepsin DSignal transducing adaptor proteinKinaseChemistryNotch proteinsImmunologyAutophagyNUMBAsymmetric cell divisionMetastasisTriple-negative breast cancerLysosomePericentriolar materialStem cellCell cycleProtein degradationMultipolar spindlesNeural developmentCancer researchBreast cancerBiochemistryFragmentation (cell biology)Signal transductionMedicineEpithelial–mesenchymal transitionEndocytic cycleA549 cellCell culturePolo-like kinaseBiologyMitosisCell biologyCancer cell
4Publications
3H-index
51Citations
Publications 5
Newest
#1Ximing Shao (CAS: Chinese Academy of Sciences)H-Index: 5
#2Zhihao Ding (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Haiyan Sun (CAS: Chinese Academy of Sciences)H-Index: 3
view all 26 authors...
Although nanomaterials have shown promising biomedical application potential, incomplete understanding of their molecular interactions with biological systems prevents their inclusion into mainstream clinical applications. Here we show that black phosphorus (BP) nanomaterials directly affect the cell cycle's centrosome machinery. BP destabilizes mitotic centrosomes by attenuating the cohesion of pericentriolar material and consequently leads to centrosome fragmentation within mitosis. As a resul...
1 CitationsSource
#1Ke Liu (CAS: Chinese Academy of Sciences)H-Index: 7
#2Lijing Fang (CAS: Chinese Academy of Sciences)H-Index: 8
Last. Hongchang Li (CAS: Chinese Academy of Sciences)H-Index: 12
view all 17 authors...
The serine/threonine kinase Polo-like kinase 1 (Plk1) plays a pivotal role in cell proliferation and has been validated as a promising anticancer drug target. However, very limited success has been achieved in clinical applications using existing Plk1 inhibitors, due to lack of sufficient specificity toward Plk1. To develop a novel Plk1 inhibitor with high selectivity and efficacy, we designed and synthesized a pyrrole-imidazole polyamide-Hoechst conjugate, PIP3, targeted to specific DNA sequenc...
12 CitationsSource
#1Ximing Shao (CAS: Chinese Academy of Sciences)H-Index: 5
#2Zhihao Ding (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Hongchang Li (CAS: Chinese Academy of Sciences)H-Index: 12
view all 11 authors...
Abstract The biological antagonism between the signaling proteins Numb and Notch has been implicated in the regulation of many developmental processes, especially in asymmetric cell division. Mechanistic studies show that Numb inactivates Notch via endocytosis and proteasomal degradation that directly reduce Notch protein levels at the cell surface. However, some aspects of how Numb antagonizes Notch remain unclear. Here, we report a novel mechanism in which Numb acts as a Notch antagonist by co...
12 CitationsSource
#1Haiyan Sun (CAS: Chinese Academy of Sciences)H-Index: 3
#2Yi Liu (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Hongchang Li (CAS: Chinese Academy of Sciences)H-Index: 12
view all 10 authors...
Abstract Autophagy is a lysosome-dependent catabolic process involving in the degradation and recycling of unnecessary or damaged proteins and organelles. Emerging evidence indicates that autophagy dysfunction is closely related to various human diseases including cancer, aging, myopathies and neurodegenerative disorders. Here, using genetic knockdown, we uncover the role of Numb, an endocytic adaptor protein, in regulating the late steps of autophagy. We found that Numb depletion led to the acc...
3 CitationsSource
#1Jianchao Zhang (CAS: Chinese Academy of Sciences)H-Index: 5
#2Ximing Shao (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Hongchang LiH-Index: 12
view all 11 authors...
// Jianchao Zhang 1 , Ximing Shao 1 , Haiyan Sun 1 , Ke Liu 1 , Zhihao Ding 1 , Juntao Chen 1 , Lijing Fang 1 , Wu Su 1 , Yang Hong 4 , Huashun Li 2, 3 , Hongchang Li 1 1 Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China 2 SARITEX Center for Stem Cell Engineering Translational Medicine, ...
37 CitationsSource