Jeffrey J. Johnson
University of Notre Dame
PhysicsCancerInternal medicinePathologymicroRNACellCadherinMolecular biologyRegulation of gene expressionAdipose tissueMaterials scienceTissue microarrayCapillary actionImmunologyIn vivoPeritoneumFluorescence in situ hybridizationPeritoneal cavityCaenorhabditis elegansMetastasisDiseaseOvarian cancerCancer researchUrokinase receptorMedicineIn situ hybridizationCell culturePlasmaBiologyCell biology
37Publications
17H-index
920Citations
Publications 38
Newest
#1Yueying Liu (ND: University of Notre Dame)H-Index: 16
#2Jing Yang (ND: University of Notre Dame)H-Index: 4
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 28 authors...
Abstract The majority of women with ovarian cancer are diagnosed with metastatic disease, therefore elucidating molecular events that contribute to successful metastatic dissemination may identify additional targets for therapeutic intervention and thereby positively impact survival. Using two human high grade serous ovarian cancer cell lines with inactive TP53 and multiple rounds of serial in vivo passaging, we generated sublines with significantly accelerated intra-peritoneal (IP) growth. Comp...
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#1Elizabeth I. Harper (ND: University of Notre Dame)H-Index: 6
#2Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 14 authors...
Ovarian cancer (OvCa) is the deadliest cancer of the female reproductive system, ranking fifth in overall cancer deaths among women. Unlike the majority of cancers, OvCa metastasizes via diffusion through the peritoneal cavity, resulting in multiple metastatic sites, including the omentum and peritoneum. These metastasizing OvCa cells induce rapid mesothelial cell retraction and readily adhere to the sub-mesothelial collagen of the extracellular matrix. Epidemiologic data identifies age as a sig...
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#1Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
#2Annemarie K. Leonard (ND: University of Notre Dame)H-Index: 2
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 17 authors...
Abstract Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little...
9 CitationsSource
#1Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
#2Ryan C. Phan (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 15 authors...
Ovarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer met...
1 CitationsSource
#1Yuliya Klymenko (ND: University of Notre Dame)H-Index: 8
#2Jeffrey J. Johnson (ND: University of Notre Dame)H-Index: 17
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 18
view all 7 authors...
Abstract Epithelial ovarian carcinoma spreads via shedding of cells and multicellular aggregates (MCAs) from the primary tumor into peritoneal cavity, with subsequent intraperitoneal tumor cell:mesothelial cell adhesion as a key early event in metastatic seeding. Evaluation of human tumor extracts and tissues confirms that well-differentiated ovarian tumors express abundant E-cadherin (Ecad), whereas advanced lesions exhibit upregulated N-cadherin (Ncad). Two expression patterns are observed: "m...
32 CitationsSource
#1Alison DeatschH-Index: 3
#2Nan SunH-Index: 4
Last. Steven RuggieroH-Index: 14
view all 6 authors...
#1Sunny S. Shah (ND: University of Notre Dame)H-Index: 3
#2Satyajyoti Senapati (ND: University of Notre Dame)H-Index: 27
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 7 authors...
Mucosal infection by the human papillomavirus (HPV) is responsible for a growing number of malignancies, predominantly represented by cervical cancer and oropharyngeal squamous cell carcinoma. Because of the prevalence of the virus, persistence of infection, and long latency period, novel and low-cost methods are needed for effective population level screening and monitoring. We review established methods for screening of cervical and oral cancer as well as commercially-available techniques for ...
24 CitationsSource
#1Jeffrey J. Johnson (ND: University of Notre Dame)H-Index: 17
#2Daniel L. Miller (MU: University of Missouri)H-Index: 3
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 18
view all 10 authors...
Abstract Oral cancer is the sixth most common cause of death from cancer with an estimated 400,000 deaths worldwide and a low (50%) 5-year survival rate. The most common form of oral cancer is oral squamous cell carcinoma (OSCC). OSCC is highly inflammatory and invasive, and the degree of inflammation correlates with tumor aggressiveness. The G protein-coupled receptor protease-activated receptor-2 (PAR-2) plays a key role in inflammation. PAR-2 is activated via proteolytic cleavage by trypsin-l...
24 CitationsSource
#1Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
#2Ryan Phan (ND: University of Notre Dame)
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 11 authors...
Ovarian cancer is the most fatal gynecological cancer. Epithelial ovarian cancer (OvCa), the most common subtype, usually goes undetected until metastatic and often fatal stages of the disease. OvCa follows a unique form of metastasis, spreading through the peritoneal cavity and forming metastatic sites on the peritoneum. Epidemiologic data suggest that child-bearing, or parity, reduces a woman9s risk of developing ovarian cancer, with more births providing greater protection. Despite the associ...
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#1Yueying Liu (ND: University of Notre Dame)H-Index: 16
#2Matthew N. Metzinger (ND: University of Notre Dame)H-Index: 3
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 22 authors...
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy, with high mortality attributable to widespread intraperitoneal metastases. Recent meta-analyses report an association between obesity, ovarian cancer incidence, and ovarian cancer survival, but the effect of obesity on metastasis has not been evaluated. The objective of this study was to use an integrative approach combining in vitro , ex vivo , and in vivo studies to test the hypothesis that obesity contr...
48 CitationsSource