Hao Liu
Southern Medical University
CancerInternal medicineRadiologySurgeryOncologyRetrospective cohort studyRandomized controlled trialStage (cooking)ChemistryLaparoscopic surgeryMetastasisLaparoscopyGastrectomyLymph nodeCancer researchProportional hazards modelColorectal cancerMedicineCohortBiologyGastroenterology
156Publications
22H-index
2,008Citations
Publications 153
Newest
#1Xing Huang (Southern Medical University)
#2Hao Liu (Southern Medical University)H-Index: 22
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 6 authors...
BACKGROUND The prognosis of stage III gastric cancer (GC) patients based on the 8th edition TNM staging system after D2 dissection was still heterogeneous. We aimed to explore clinicopathological reasons that led to the poor prognosis of these patients, especially from a surgical aspect. METHODS We divided 320 stage III GC patients who underwent distal or total gastrectomy with D2 lymphadenectomy into group 1 and group 2, according to the disease-free survival (DFS), and compared the clinicopath...
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#1Yichang Wang (Xi'an Jiaotong University)
#2Alafate Wahafu (Xi'an Jiaotong University)H-Index: 3
Last. Jia Wang (Xi'an Jiaotong University)H-Index: 7
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Low-grade gliomas (LGGs) are grade III gliomas based on the WHO classification with significant genetic heterogeneity and clinical properties. Traditional histological classification of gliomas has been challenged by the improvement of molecular stratification; however, the reproducibility and diagnostic accuracy of LGGs classification still remain poor. Herein, we identified fatty acid binding protein 5 (FABP5) as one of the most enriched genes in malignant LGGs and elevated FABP5 revealed seve...
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#1Yanrui Liang (Southern Medical University)H-Index: 2
#2Liying Zhao (Southern Medical University)H-Index: 17
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 10 authors...
BACKGROUND The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effectiveness and complications of adjuvant chemotherapy in patients > 65 years of age after laparoscopic D2 gastrectomy. METHODS This was a single-center retrospective cohort study of elderly patients (> 65 years) with stage II/III GC who underwent curative laparoscopic D2 gastrectomy...
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#1Mansheng Zhu (Southern Medical University)
#2Qixiang Liang (SYSU: Sun Yat-sen University)
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 12 authors...
BACKGROUND The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein-Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extensive DNA methylation, including miRNAs. However, the role of methylated miRNA in the development of EBVaGC and immune cell infiltration has largely remained elusive. RESULTS After crossmatching the DNA methylation and expression profile of miRNA and mRNA in the Gene Expression Omn...
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#1Chen Xinhua (Southern Medical University)H-Index: 4
#2Yu Zhu (Southern Medical University)H-Index: 4
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 11 authors...
Background: The enhanced recovery after surgery (ERAS) programme is feasible and effective in reducing the length of hospital stay, overall complication rates and medical costs when applied to cases involving colonic and rectal resections. However, a recent prospective, randomised, open, parallel-controlled trial (Chinese Laparoscopic Gastrointestinal Surgery Study-01 trial), initiated by our team, indicated that under conventional peri-operative management, the reduction of the post-operative h...
1 CitationsSource
#1Zhenzhan Zhang (Southern Medical University)H-Index: 1
#2Jianguang Ji (Lund University)H-Index: 36
Last. Hao Liu (Southern Medical University)H-Index: 22
view all 3 authors...
BACKGROUND: Drug repurposing, the application of known drugs and compounds with a non-oncology primary purpose, might be an attractive strategy to offer more effective treatment options to patients with cancer at a low cost and reduced time.METHODS: This review described a total of 10 kinds of non-oncological drugs from more than 100 mechanical studies as well as evidence from population-based studies. The future direction of repurposed drug screening was discussed by using patient-derived tumor...
1 CitationsSource
#1Zhian Chen (Southern Medical University)H-Index: 2
#2Yanrui Liang (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 16 authors...
Among various methods, the use of targeting nucleic acid therapy is a promising method for inhibiting gastric cancer (GC) cells' rapid growth and metastasis abilities. In this study, vitamin B12-labeled poly (d,l-lactide-co-glycolide) and polyethylene glycol nanoparticles (PLGA-PEG-VB12 NPs) were developed for microRNAs-532-3p mimics incorporating as targeting gene delivery systems (miR-532-3p@PLGA-PEG-VB12 NPs) to fight against transcobalamin II (CD320)-overexpressed GC cells' progression. The ...
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#1Xing Huang (Southern Medical University)
#2Hao Liu (Southern Medical University)
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 6 authors...
Abstract Objective The prognostic factors for patients with T1-2 colorectal cancer (CRC) after radical resection and the predictive value of lymph node distribution (LND) system compared with TNM system for these patients have not been well studied. Methods From September 2009 and June 2016, a total of 541 consecutive patients with T1-2 CRC who accepted radical resection in two centers were included in this study. Their clinicopathological characteristics and prognosis were analyzed using univar...
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#1Changming HuangH-Index: 1
#1Chang-Ming HuangH-Index: 2
Last. Guoxin Li (Southern Medical University)H-Index: 33
view all 23 authors...
BACKGROUND: It is not clear whether laparoscopic and open distal gastrectomy produce similar outcomes in patients with locally advanced gastric cancer. Data from a multicenter, randomized, controlled trial (CLASS-01) showed that laparoscopic distal gastrectomy did not result in inferior disease-free survival at 3 years compared with open distal gastrectomy. Here, we present 5-year overall survival data from this trial. METHODS: From September 2012 through December 2014, we randomly assigned 1056...
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#1Chen XinhuaH-Index: 4
#3Chen YuehongH-Index: 3
Last. Jiang YuH-Index: 27
view all 12 authors...
Objective This study aimed to determine the impact of type 2 diabetes mellitus (T2DM) on clinical outcomes of gastric cancer (GC) patients and explore whether metformin use and good glycemic control could reverse it. Methods Clinicopathologic data of consecutive GC patients who underwent gastrectomy at Nanfang Hospital between October 2004 and December 2015 were included. Propensity score matching (PSM) was performed to balance the important factors of the disease status between non-T2DM and T2D...
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