Carl T. Olson
Battelle Memorial Institute
PharmacokineticsSurgeryChemistryIn vivoMethemoglobinAtropineNerve agentAcetylcholinesterasePyridostigmineSomanSulfur mustardPralidoxime chloridePyridostigmine BromideToxicityToxicologyComputer scienceAnesthesiaChromatographyMedicinePharmacology
30Publications
9H-index
357Citations
Publications 30
Newest
#1David E. LenzH-Index: 29
#2Donald M. MaxwellH-Index: 24
Last. Carl T. Olson (Battelle Memorial Institute)H-Index: 9
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Abstract Human butyrylcholinesterase (HuBuChE), purified from outdated human plasma, is being evaluated for efficacy against nerve agents in guinea pigs and cynomolgus monkeys. Previous studies in rodents and nonhuman primates demonstrated that pretreatment of animals with enzymes that can scavenge nerve agents could provide significant protection against behavioral and lethal effects of nerve agent intoxication. In preparation for evaluation of efficacy of HuBuChE prior to initiating an investi...
111 CitationsSource
#1Rudolph C. Johnson (CDC: Centers for Disease Control and Prevention)H-Index: 18
#2Sharon W. Lemire (CDC: Centers for Disease Control and Prevention)H-Index: 10
Last. John R. Barr (CDC: Centers for Disease Control and Prevention)H-Index: 55
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Ricin is a toxalbumin derived from the castor bean plant, Ricinus communis. Ricinine is an alkaloid (3-cyano-4-methoxy-Nmethyl-2-pyridone) that shares a common plant source with ricin, and its presence in urine infers ricin exposure. A new quantification method for ricinine was developed that uses solid-phase extraction to prepare 1-mL urine samples (81% recovery) for a 5-rain, isocratic high-performance liquid chromatography method, followed by electrospray ionization tandem mass spectrometry. ...
76 CitationsSource
#1Sharon W. Lemire (CDC: Centers for Disease Control and Prevention)H-Index: 10
#2John R. Barr (CDC: Centers for Disease Control and Prevention)H-Index: 55
Last. Timothy L. Hayes (Battelle Memorial Institute)H-Index: 6
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The nitrogen mustards bis(2-chloroethyl)ethylamine (HN1), bis(2-chloroethyl)methylamine (HN2), and tris(2-chloroethyl)amine (HN3) have the potential to be used as chemical terrorism agents because of their extreme vesicant properties. We modified a previously reported method to incorporate automated solid-phase extraction, improve chromatography, and include the urinary metabolite for HN3. The improved method was used to measure levels of the urinary metabolites N-ethyldiethanolamine (EDEA), N-m...
24 CitationsSource
#1Carl T. OlsonH-Index: 9
#2Michele M. DanneH-Index: 2
Last. Kristi L. BuxtonH-Index: 2
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Abstract : The objective of this study was to investigate the pharmacologic modulation of biomarkers for evaluating therapeutics against HD. The molecular biomarkers investigated, using a ribonuclease protection assay (RPA) to determine messenger ribonucleic acid (mRNA) levels, were mediators of inflammation, including several cytokines and chemokines, tenascin, and ornithine decarboxylase. Biochemical biomarkers investigated were serum amyloid P (SAP), interleukin-6 (IL-6), and interleukin-1 al...
#1Carl T. OlsonH-Index: 9
#2Robert E. HuntH-Index: 13
Last. Nancy A. NiemuthH-Index: 11
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Abstract : Studies (MREF Tasks 95-39, 96-45, 97-51, and 97-52) have previously demonstrated a high degree of correlation between circulating neutralizing antibody titers and protection against high doses of all botulinum toxin serotypes in the guinea pig model. Neutralizing antibodies have been proposed to the FDA as a serological marker for human protection since efficacy for This vaccine cannot be directly demonstrated in traditional human clinical trials. Task 97-53 establishes the level of p...
#1Carl T. OlsonH-Index: 9
#2Frances M. ReidH-Index: 9
Last. James E. EstepH-Index: 8
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Abstract : Task 97-48 was conducted in two phases: 1) develop a 72-hr anesthetized, ventilated respiratory casualty swine model and 2) assess treatment efficacy of a) 10-15 cm of water positive end expiratory pressure (PEEP) with 45 percent oxygen, b) Ibuprofen (IBU), and c) n-acetyl- cysteine (NAC). The early diagnostic capability for pulmonary edema (PE) using the impedance cardiograph was evaluated in Phase II. Phosgene (CG) was selected as the respiratory insult and exposures ranged from 250...
Source
#1Carl T. OlsonH-Index: 9
#2Robyn C. KiserH-Index: 9
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Abstract : The mouse ear model has been used at the U.S. Army Medical Institute of chemical Defense (USAMRICD) to assess dermal injury caused by sulfur mustard (HD) and to evaluate potential pre- and posttreatment compounds for efficacy against percutaneous HD injury. In this model, the effects of HD with or without treatment compounds are evaluated macroscopically by edema and microscopically by histopathological changes associated with HD injury. The objectives of Task 9543 were first to trans...
#1Eugene J. Olajos (DA: United States Department of the Army)H-Index: 5
#2Carl T. Olson (Battelle Memorial Institute)H-Index: 9
Last. B. MacIverH-Index: 1
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Vesication and skin irritation studies were conducted in hairless guinea-pigs to determine the vesicant and skin irritation potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). The CAIS are training items that contain chemical warfare-related material—sulfur mustard (HD), nitrogen mustard (HN) or lewisite (L)—and were declared obsolete in 1971. Animals were dosed topically with ‘test article’—neat HD, 10% agent/chloroform solutions or product solutions (waste-streams) f...
9 CitationsSource
#1Carl T. Olson (Battelle Memorial Institute)H-Index: 9
#2James A. Blank (Battelle Memorial Institute)H-Index: 6
Last. Ronald G. Menton (Battelle Memorial Institute)H-Index: 8
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A study is being initiated to investigate subtle neurobehavioral effects and neuropathology in rats due to exposure to combinations of low levels of Sarin (GB), N, N-diethyl-m-toluamide (DEET), chlorpyrifos (CPF), and pyridostigmine bromide (PB). A similar study is being initiated in rhesus monkeys to investigate neurophysiology effects and neuromuscular pathology due to exposure to a combination of GB, DEET, CPF, and PB, along with vaccination with botulinum toxoid. A description of these studi...
9 CitationsSource
#1Carl T. OlsonH-Index: 9
#2Timothy L. HayesH-Index: 6
Last. Robyn C KiserH-Index: 1
view all 5 authors...
Abstract : Vesication and skin irritation studies were conducted in hairless guinea pigs to ascertain the vesicant and skin irritation potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). CAIS are training items that contain agent (HD, HN, or L) and were declared obsolete in 1971. Animals were dosed with 'test article' EITHER NEAT HD, 10% agent/chloroform solutions or product solutions (wastestreams) and evaluated for skin-damaging effects (gross and light microscopic)....