Jiayin Zhou
CancerHippocampal formationTumor necrosis factor alphaApoptosisImmunologyNeuroprotectionTLR4InflammationAstrocyteTNF receptor associated factorDementiaMicrogliaGlial fibrillary acidic proteinHippocampusMedicineNeuroinflammationAmyloidPharmacology
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#1Jiayin ZhouH-Index: 2
#2Yuanyuan Deng (Zunyi Medical College)H-Index: 12
Last. Qi-Hai Gong (Zunyi Medical College)H-Index: 21
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Abstract Inflammation in central nervous system (CNS) plays a vital role in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Lewy body dementia (DLB), HIV-related dementia and traumatic brain injury. Icariside II (ICS II), an active flavonoid compound derived from a Chinese herbal medicine Epimedium brevicornum Maxim, has been shown to possess a neuroprotective effect on AD model. However, whether ICS II has a directly protective effect on acute neuroinflamm...
21 CitationsSource
#1Yuanyuan DengH-Index: 1
#2Long LongH-Index: 1
Last. Qihai GongH-Index: 1
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Beta-amyloid (Aβ) deposition, associated neuronal apoptosis and neuroinflammation are considered as the important factors which lead to cognitive deficits in Alzheimer’s disease (AD). Icariside II (ICS II), an active flavonoid compound derived from Epimedium brevicornum Maxim, has been extensively used to treat erectile dysfunction, osteoporosis and dementia in traditional Chinese medicine. Recently, ICS II attracts great interest due to its broad-spectrum anti-cancer property. ICS II shows an a...
23 CitationsSource