Celalettin Yurdakul
Boston University
Human–computer interactionReflectivityOpticsMicroscopyInterference microscopyArtificial intelligenceNanoparticleBiosensorInterferometryNanotechnologyPhotothermal therapyScatteringMaterials scienceInterferometric microscopyWide fieldComputer scienceOptoelectronicsChemical imagingMicroscopeResolution (electron density)Image sensor
23Publications
7H-index
97Citations
Publications 22
Newest
#5M. Selim Ünlü (BU: Boston University)H-Index: 27
Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal the specimen's size and shape information, the chemical composition is inaccessible in interferometric measurements. Infrared spectroscopic imaging provides chemical specificity based on inherent chemical bond vibrations of specimens but lacks the ability to i...
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#4Meng Zhang (BU: Boston University)H-Index: 15
#5M. Selim Ünlü (BU: Boston University)H-Index: 27
Mid-infrared photothermal (MIP) microscopy has been a promising label-free chemical imaging technique for functional characterization of specimens owing to its enhanced spatial resolution and high specificity. Recently developed wide-field MIP imaging modalities have drastically improved speed and enabled high-throughput imaging of micron-scale subjects. However, the weakly scattered signal from sub-wavelength particles becomes indistinguishable from the shot-noise as a consequence of the strong...
#4Meng Zhang (BU: Boston University)H-Index: 15
Mid-infrared photothermal microscopy (MIP) has been a promising chemical imaging technique for functionality characterization of biological and pharmaceutical specimens owing to its enhanced resolution and high-specificity. Recently developed wide-field MIP modalities drastically improved the imaging speed and thus enabled high-throughput imaging. However, the sensitivity of the wide-field MIP technique has been limited by shot-noise of background photons. Here, we demonstrate a dark-field MIP m...
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#1Jiaze Yin (BU: Boston University)H-Index: 2
#2Lu Lan (BU: Boston University)H-Index: 14
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 6 authors...
Mid-infrared photothermal (MIP) microscopy overcomes the resolution and huge water background limits in conventional mid-infrared imaging by probing the mid-infrared absorption induced photothermal effect. However, to detect the subtle MIP signal, large probe power and lock-in detection are needed, which limit the imaging speed of current MIP systems. To overcome this limitation, we develop a single-pixel pump-probe camera that leverages the large well-depth capacity of photodiode to achieve hig...
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#1Yi Zhang (BU: Boston University)H-Index: 3
#2Celalettin Yurdakul (BU: Boston University)H-Index: 7
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 8 authors...
We report a confocal interferometric mid-infrared photothermal (MIP) microscope for ultra-sensitive and spatially resolved chemical imaging of individual viruses. The interferometric scattering principle is applied to detect the very weak photothermal signal induced by infrared absorption of chemical bonds. Spectroscopic MIP detection of single vesicular stomatitis viruses (VSVs) and poxviruses is demonstrated. The single virus spectra show high consistency within the same virus type. The domina...
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Single particle interferometric reflectance (SPIR) microscopy has been studied as a powerful imaging platform for label-free and highly sensitive biological nanoparticle detection and characterization. SPIR's interferometric nature yields a unique 3D defocus intensity profile of the nanoparticles over a large field of view. Here, we utilize this defocus information to recover high signal-to-noise ratio nanoparticle images with a computationally and memory efficient reconstruction framework. Our ...
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#2Oguzhan AvciH-Index: 8
Last. Selim UnluH-Index: 7
view all 5 authors...
Morphological parameters of biological nanoparticles (BNPs) have strong implications on their fate and functionality in vivo e.g., circulation, biodistribution, and clearance. Although interferometric scattering microscopy modalities have demonstrated the label-free detection of sub-100 nm BNPs including viruses and exosomes; they have an insufficient spatial resolution roughly limited to the illumination wavelength. Here, we introduce computational imaging to interferometric scattering microsco...
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#2Haonan Zong (BU: Boston University)H-Index: 2
Last. Ji-Xin ChengH-Index: 84
view all 5 authors...
Chemical characterization of biological specimens in the mid-infrared (IR) window plays a central role in the analysis of their functionalities. Although recent advances in mid-IR microscopy have demonstrated detection of the sample’s chemical contrast at a sub-micron resolution using a visible probe beam, they have limited sensitivity at high-throughput. To overcome this limit, we employ wide-field interferometric microscopy to detect the minute change in the optical path induced by mid-IR abso...
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#1Celalettin Yurdakul (BU: Boston University)H-Index: 7
#2Oguzhan Avci (BU: Boston University)H-Index: 8
Last. M. Selim Ünlü (BU: Boston University)H-Index: 27
view all 11 authors...
Label-free, visible light microscopy is an indispensable tool for studying biological nanoparticles (BNPs). However, conventional imaging techniques have two major challenges: (i) weak contrast due to low-refractive-index difference with the surrounding medium and exceptionally small size and (ii) limited spatial resolution. Advances in interferometric microscopy have overcome the weak contrast limitation and enabled direct detection of BNPs, yet lateral resolution remains as a challenge in stud...
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