Ik-Soo Lee
Chonnam National University
CytotoxicityGlycationMolecular biologyCytotoxic T cellOrganic chemistryChemistryApoptosisGlycosideIn vitroIn vivoAntioxidantFlavonoidXanthohumolElastaseMicrobial transformationChromatographyBiochemistryTraditional medicineBotanyStereochemistryMedicineCell cultureBiologyPharmacology
154Publications
32H-index
3,261Citations
Publications 148
Newest
#1Ik-Soo LeeH-Index: 32
#2Chan-Sik KimH-Index: 20
Last. Jin Sook KimH-Index: 35
view all 10 authors...
A B S T R A C T null null Background: Moutan radicis cortex (MRC) and Cinnamomi ramulus (CR) are commonly used in eastern Asian traditional medicine to treat various diseases including cerebrovascular and cardiovascular, and have wide spectrum of pharmacological activities. However, the effect against laser-induced choroidal neovascularization (CNV) of extract of MRC and CR (1:1) (MRCCR) has not yet been studied. null Purpose: Our aim was to investigate the inhibitory effect of MRCCR on patholog...
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#1Yina XiaoH-Index: 2
#2Fubo HanH-Index: 3
Last. Ik-Soo LeeH-Index: 32
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Biotransformation of four bioactive phenolic constituents from licorice, namely licoisoflavanone (1), glycyrrhisoflavone (2), echinatin (3), and isobavachalcone (4), was performed by the selected fungal strain Aspergillus niger KCCM 60332, leading to the isolation of seventeen metabolites (5–21). Structures of the isolated compounds were determined on the basis of extensive spectroscopic methods, twelve of which (5–7, 10–17 and 19) have been previously undescribed. A series of reactions includin...
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#1Fubo Han (Chonnam National University)H-Index: 3
#2Ji Hye Kim (Chonnam National University)
Last. Ik-Soo Lee (Chonnam National University)H-Index: 32
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Microbial transformation is an important tool to perform selective conversion of compounds to derivatives which are difficult to produce synthetically. In order to obtain icariside II and icaritin,...
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#1Fubo Han (Chonnam National University)H-Index: 3
#2Yina Xiao (Chonnam National University)H-Index: 2
Last. Ik-Soo Lee (Chonnam National University)H-Index: 32
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Microbial conjugation studies of licochalcones (1–4) and xanthohumol (5) were performed by using the fungi Mucor hiemalis and Absidia coerulea. As a result, one new glucosylated metabolite was produced by M. hiemalis whereas four new and three known sulfated metabolites were obtained by transformation with A. coerulea. Chemical structures of all the metabolites were elucidated on the basis of 1D-, 2D-NMR and mass spectroscopic data analyses. These results could contribute to a better understandi...
2 CitationsSource
#1Yina Xiao (Chonnam National University)H-Index: 2
#2Fubo Han (Chonnam National University)H-Index: 3
Last. Ik-Soo Lee (Chonnam National University)H-Index: 32
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Broussochalcones A (BCA, 1) and B (BCB, 2) are major bioactive constituents isolated from Broussonetia papyrifera, a polyphenol-rich plant belonging to the family Moraceae. Due to their low yields from natural sources, BCA (1) and BCB (2) were prepared synthetically by employing Claisen-Schmidt condensation, and these were used as substrates for microbial transformation to obtain novel derivatives. Microbial transformation of BCA (1) and BCB (2) with the endophytic fungus Aspergillus niger KCCM ...
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#1Saugat Shiwakoti (Mokpo National University)
#2Deepak Adhikari (Mokpo National University)H-Index: 3
Last. Min-Ho Oak (Mokpo National University)H-Index: 21
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Both short- and long-term exposure to fine dust (FD) from air pollution has been linked to various cardiovascular diseases (CVDs). Endothelial cell (EC) senescence is an important risk factor for CVDs, and recent evidence suggests that FD-induced premature EC senescence increases oxidative stress levels. Hop plant (Humulus lupulus) is a very rich source of polyphenols known to have nutritional and therapeutic properties, including antioxidant behavior. The aims of this study were to evaluate whe...
1 CitationsSource
#1Bo-Ram Kim (Chonnam National University)H-Index: 7
#2Ah-Reum HanH-Index: 8
Last. Ik-Soo Lee (Chonnam National University)H-Index: 32
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Flavonoids are plant secondary metabolites that are well known for their health-promoting properties as nutraceuticals in diets. Bioavailability and biological activities of flavonoids vary among t...
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#1Bomi Nam (Chonnam National University)H-Index: 6
#2Ah-Reum HanH-Index: 8
Last. Ik-Soo Lee (Chonnam National University)H-Index: 32
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Microbial transformation of denthyrsinin (1), gigantol (2), and batatasin III (3), the major constituents of Dendrobium species (Orchidaceae), was performed using the filamentous fungus Mucor hiema...
1 CitationsSource
#1Jung Hyun KimH-Index: 60
#2Chan-Sik KimH-Index: 20
Last. Jin Sook KimH-Index: 35
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This study investigated the effects of the n-BuOH soluble fraction of Polygoni Cuspidati 80% ethanol extract (POCU1b) on high-fat diet (HFD)-induced obesity, non-alcoholic fatty liver (NAFL), and insulin resistance (IR) to find a safe and more effective agent. HPLC profiling of POCU1b identified seven marker compounds. POCU1b increased glycerol release, cyclic adenosine monophosphate (cAMP) level, and inhibited phosphodiesterase (PDE) activity. Seven weeks of POCU1b treatment decreased body weig...
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#1Bo-Ram KimH-Index: 7
#2Sunil Babu Paudel (Yeungnam University)H-Index: 2
Last. Ah-Reum HanH-Index: 8
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A new polyacetylene glycoside, (5R)-6E-tetradecene-8,10,12-triyne-1-ol-5-O-β-glucoside (1), was isolated from the flower of Coreopsis lanceolata (Compositae), together with two known compounds, bidenoside C (10) and (3S,4S)-5E-trideca-1,5-dien-7,9,11-triyne-3,4-diol-4-O-β-glucopyranoside (11), which were found in Coreopsis species for the first time. The other known compounds, lanceoletin (2), 3,2'-dihydroxy-4-3'-dimethoxychalcone-4'-glucoside (3), 4-methoxylanceoletin (4), lanceolin (5), leptos...
5 CitationsSource