P. Miodini
CA15-3CancerEndocrinologyPathologyOncologyReceptorGrowth factorEstrogenMammary glandGenisteinCell cycleCancer researchBreast cancerCirculating tumor cellCell growthMedicineCell cultureEstrogen receptorBiologyProgesterone receptor
48Publications
17H-index
898Citations
Publications 48
Newest
Circulating tumor cells (CTCs) are promising biomarkers for prognosis, therapeutic response prediction, and treatment monitoring in cancer patients. Despite its epithelial origin, renal cell carcinoma (RCC) shows low expression of epithelial markers hindering CTC-enrichment approaches exploiting epithelial cell surface proteins. In 21 blood samples serially collected from 10 patients with metastatic RCC entering the TARIBO trial, we overcame this limitation using the marker-independent Parsortix...
3 CitationsSource
#1Pierangela SepeH-Index: 5
#1Pierangela SepeH-Index: 4
Last. Maria Grazia DaidoneH-Index: 59
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Enzalutamide and abiraterone have been shown to improve progression-free survival (PFS) and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients. Moreover, some patients may not benefit from the inhibition of androgen receptor (AR) activity or, alternatively, may develop secondary resistance. Detection in patients’ circulating tumor cells (CTCs) of ARV7, a splicing variant of AR lacking the ligand-binding domain, showed a link with treatment failure. Independ...
5 CitationsSource
#1Carolina ReduzziH-Index: 5
#2Marta VismaraH-Index: 2
Last. Vera CappellettiH-Index: 20
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#1C. FerrarisH-Index: 10
Last. S. FolliH-Index: 2
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1 CitationsSource
#1Vera CappellettiH-Index: 20
#2P. MiodiniH-Index: 17
Last. Laura D. LocatiH-Index: 29
view all 7 authors...
4 CitationsSource
Metachronous (MBC) and synchronous bilateral breast tumors (SBC) are mostly distinct primaries, whereas paired primaries and their local recurrences (LRC) share a common origin. Intra-pair gene expression variability in MBC, SBC, and LRC derives from time/tumor microenvironment-related and tumor genetic background-related factors and pairs represents an ideal model for trying to dissect tumor-related from microenvironment-related variability. Pairs of tumors derived from women with SBC (n = 18),...
1 CitationsSource
#1Vera CappellettiH-Index: 20
#2Egidio Iorio (ISS: Istituto Superiore di Sanità)H-Index: 22
Last. Maria Grazia DaidoneH-Index: 59
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Cancer treatment options are increasing. However, even among the same tumor histotype, interpatient tumor heterogeneity should be considered for best therapeutic result. Metabolomics represents the last addition to promising “omic” sciences such as genomics, transcriptomics, and proteomics. Biochemical transformation processes underlying energy production and biosynthetic processes have been recognized as a hallmark of the cancer cell and hold a promise to build a bridge between genotype and phe...
22 CitationsSource
#1Giuseppe MerlinoH-Index: 5
#2P. MiodiniH-Index: 17
Last. Maria Grazia DaidoneH-Index: 59
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None of the clinically relevant gene expression signatures available for breast cancer were specifically developed to capture the influence of the microenvironment on tumor cells. Here, we attempted to build subtype-specific signatures derived from an in vitro model reproducing tumor cell modifications after interaction with activated or normal stromal cells. Gene expression signatures derived from HER2+, luminal and basal breast cancer cell lines (treated by normal fibroblasts or cancer-associa...
1 CitationsSource
#1Giuseppe MerlinoH-Index: 5
#2P. MiodiniH-Index: 17
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#2Giuseppe MerlinoH-Index: 5
Last. Vera CappellettiH-Index: 20
view all 5 authors...
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