Lior H. Katz
Hadassah Medical Center
CancerInternal medicineRadiologyOncologyOdds ratioPediatricsLynch syndromeInflammatory bowel diseaseColonoscopyDiseaseCrohn's diseaseUlcerative colitisPopulationIncidence (epidemiology)Cancer researchColorectal cancerMedicineCohortGastroenterologyMeta-analysis
Publications 108
#2John-Paul Plazzer (Royal Melbourne Hospital)H-Index: 12
Last. Francesc Balaguer (University of Barcelona)H-Index: 44
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Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in ...
#1Ido Laish (TAU: Tel Aviv University)H-Index: 7
#2Yael Goldberg (Rabin Medical Center)H-Index: 17
Last. Gili Levi-Reznick (Rambam Health Care Campus)
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Abstract null null Background null Routine screening for establishing Lynch syndrome (LS) in young individuals diagnosed with adenomas is not recommended due to its low yield, and limited sensitivity of the employment of immunohistochemistry for DNA mismatch-repair proteins on polyps. Hence we aimed to evaluate the yield of germline mutational analysis in diagnosis of LS in a young Israeli cohort with colorectal adenomatous polyps. null null null Methods null Data were retrospectively collected ...
#1Ido Laish (Sheba Medical Center)H-Index: 1
#1Ido Laish (TAU: Tel Aviv University)H-Index: 7
Last. Yael Goldberg (Rabin Medical Center)H-Index: 17
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BACKGROUND Hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), the most common inherited cancer syndromes, are attributed to a single heterozygous pathogenic variant (PV) in BRCA1/2 or in a DNA MMR gene, respectively. Little is known about the phenotype in double heterozygotes who carry PVs in both genes. METHODS Carriers of double-PVs in any DNA MMR gene and BRCA1/2 attending one of three tertiary oncogenetic clinics between 1/2005 and 1/2020 were identified by databas...
#1Inbal Kedar (Rabin Medical Center)H-Index: 8
#2L Walsh (UW: University of Washington)
Last. Yael Goldberg (Rabin Medical Center)H-Index: 17
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Lynch syndrome is an inherited cancer predisposition syndrome caused by germline defects in any of the mismatch repair (MMR) genes. Diagnosis of carriers makes precision prevention, early detection, and tailored treatment possible. Herein we report a novel founder deletion of 18,758 bp, mediated by Alu repeats on both sides, detected in Ethiopian Jews. The deletion, which encompasses exon 9-10 of the MSH2 coding sequence, is associated mainly with early-onset MSH2/MSH6-deficient colorectal cance...
#2Emma J Crosbie (University of Manchester)H-Index: 26
Last. Pål MøllerH-Index: 55
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Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR (path_MMR) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1, path_MSH2, path...
1 CitationsSource
#1Toni T. Seppälä (Johns Hopkins University)H-Index: 17
Last. Pål MøllerH-Index: 55
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Abstract Purpose This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. Methods The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30–69 years. Results Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, resp...
#1Erez N. Baruch (TAU: Tel Aviv University)H-Index: 13
#2Ilan Youngster (TAU: Tel Aviv University)H-Index: 22
Last. Ben Boursi (TAU: Tel Aviv University)H-Index: 12
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The gut microbiome has been shown to influence the response of tumors to anti-PD-1 immunotherapy in pre-clinical mouse models and observational patient cohorts. However, modulation of gut microbiota in cancer patients has not been investigated in clinical trials. Here we performed a phase I clinical trial to assess the safety and feasibility of fecal microbiota transplantation (FMT) and re-induction of anti-PD-1 immunotherapy in ten patients with anti-PD-1-refractory metastatic melanoma. We obse...
27 CitationsSource
#1Tawfik KhouryH-Index: 11
#2Fares Darawsheh (Hadassah Medical Center)H-Index: 1
Last. Wisam SbeitH-Index: 6
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BACKGROUND: To characterize variables that may predict the need for endoscopic intervention in inpatients admitted for several causes who during the hospitalization developed acute non-variceal upper gastrointestinal bleeding (NVUGIB). METHODS: A retrospective analysis of inpatients who underwent upper GI endoscopy for acute NVUGIB while hospitalized for other causes from 1st January 2016 till 1st December 2017, was performed. In the primary outcome analysis, patients (n: 14) who underwent endos...
1 CitationsSource
#1Oshrat Levi-Galibov (Weizmann Institute of Science)H-Index: 3
#2Hagar Lavon (Weizmann Institute of Science)H-Index: 7
Last. Ruth Scherz-Shouval (Weizmann Institute of Science)H-Index: 17
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In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease. While the causal and clinical links are well established, molecular understanding of how chronic inflammation leads to the development of colon cancer is lacking. Here we deconstruct the evolving microenvironment of CAC by measuring proteomic changes and extracellular matrix (ECM) organization over time in a mouse model of CAC. We detect early changes...
4 CitationsSource