Ahmad Sadique
Memorial Sloan Kettering Cancer Center
TautomerPharmacokineticsCrystal structureCancerPET-CTDNA repairMolecular imagingPathologyDNA damageNanomedicineMolecular biologyMedicinal chemistryCis–trans isomerismPoly ADP ribose polymeraseChemistryApoptosisIn vitroImmunologyIn vivoEx vivoPositron emission tomographyInflammationHumanized antibodyAntibody-drug conjugateAcetonitrileBiodistributionImaging agentDimethyl sulfoxidePARP1Diffuse large B-cell lymphomaBrain tumorPARP inhibitorTumor progressionLymphomaMalignancyLymphFolate receptorIndazolePopulationPositron Emission Tomography-Computed TomographyExperimental therapyPreclinical imagingRadionuclide therapyQuantification methodsSalt metathesis reactionCancer researchRadiation therapyOsmiumRutheniumCrystal systemComputational biologyStereochemistryMedicineBiologyCancer cellPharmacology
12Publications
4H-index
77Citations
Publications 8
Newest
#1Giacomo Pirovano (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 9
#2Stephen A. Jannetti (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
Last. Thomas Reiner (Cornell University)H-Index: 39
view all 12 authors...
Purpose: Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent decades. Experimental design: 123 I-MAPi (Iodine-123 Meitner-Auger PARP1 inhibitor) is a precise therapeutic tool composed of a PARP1 inhibitor radiolabeled with an Auger- and gamma-emitting iodine isotope. Here, the PARP inhibitor, which binds to the DNA repai...
22 CitationsSource
#1Christian Brand (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 15
#2Ahmad Sadique (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
Last. Thomas Reiner (Cornell University)H-Index: 39
view all 9 authors...
Background The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim of this study is to develop an antibody-derived immuno-PET imaging agent strategy for targeting FRα in ovarian cancer as a predictor of treatment success.
3 CitationsSource
#1Stephen A. Jannetti (CUNY: City University of New York)H-Index: 6
#2Giuseppe Carlucci (NYU: New York University)H-Index: 27
Last. Thomas Reiner (Cornell University)H-Index: 39
view all 19 authors...
: The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of specific small molecule inhibitors, PARP-1 is a near-ideal target to develop novel radiotherapeutics to induce DNA damage and apoptosis in cancer cells, while sparing healthy brain tissue. Methods: We synthesized an 131I-labeled PARP-1 therapeutic and investigated its pharmacology in vitro and in vivo. A subcutaneous...
16 CitationsSource
#1Gabriel E. Büchel (KAUST: King Abdullah University of Science and Technology)H-Index: 2
#2Susanne Kossatz (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 15
Last. Vladimir B. Arion (University of Vienna)H-Index: 57
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The relationship between cis–trans isomerism and anticancer activity has been mainly addressed for square-planar metal complexes, in particular, for platinum(II), e.g., cis- and trans-[PtCl2(NH3)2], and a number of related compounds, of which, however, only cis-counterparts are in clinical use today. For octahedral metal complexes, this effect of geometrical isomerism on anticancer activity has not been investigated systematically, mainly because the relevant isomers are still unavailable. An ex...
6 CitationsSource
#1Jun Tang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 27
#2Darin Salloum (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 9
Last. Thomas Reiner (Cornell University)H-Index: 39
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Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. DLBCL exhibits highly aggressive and systemic progression into multiple tissues in patients, particularly in lymph nodes. Whole-body 18F-fluodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging has an essential role in diagnosing DLBCL in the clinic; however, [18F]FDG-PET often faces difficulty in differentiating malignant tissues from certain nonmalignant tissues with high glucose uptake. We have d...
18 CitationsSource
#1Giuseppe Carlucci (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 27
#2Brandon Carney (CUNY: City University of New York)H-Index: 9
Last. Thomas Reiner (Cornell University)H-Index: 39
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Abstract Rationale Ataxia telangiectasia and Rad3-related (ATR) threonine serine kinase is one of the key elements in orchestrating the DNA damage response (DDR). As such, inhibition of ATR can amplify the effects of chemo- and radiation-therapy, and several ATR inhibitors (ATRi) have already undergone clinical testing in cancer. For more accurate patient selection, monitoring and staging, real-time in vivo imaging of ATR could be invaluable; the development of appropriate imaging agents has rem...
2 CitationsSource
#1Jun Tang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 27
#2Carlos Pérez-Medina (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 21
Last. Thomas Reiner (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 39
view all 6 authors...
Inspired by the success of previous cancer nanomedicines in the clinic, researchers have generated a large number of novel formulations in the past decade. However, only a small number of nanomedicines have been approved for clinical use, whereas the majority of nanomedicines under clinical development have produced disappointing results. One major obstacle to the successful clinical translation of new cancer nanomedicines is the lack of an accurate understanding of their in vivo performance. Th...
3 CitationsSource
#1Gabriel E. BüchelH-Index: 10
#2Susanne KossatzH-Index: 15
Last. Vladimir B. ArionH-Index: 57
view all 11 authors...
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