K. Balagangadharan
SRM University
BiophysicsDownregulation and upregulationBone cellBiomedical engineeringElectrospinningChemistryMaterials scienceMesenchymal stem cellRUNX2BiocompatibilityOsteoblastBone tissueGelatinChitosanPolycaprolactoneStem cellBone regenerationTissue engineeringNanofiberCell biology
18Publications
10H-index
396Citations
Publications 17
Newest
#1R. Abhinandan (SRM University)H-Index: 2
#2S. Pranav Adithya (SRM University)H-Index: 1
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Abstract Boride, which belongs to the distinct category of ceramic materials, has attracted significant attention in tissue engineering applications. Magnesium diboride (MgB2) consists of a plane of magnesium atoms sandwiched between the layers of boron. Even though MgB2 showed its role in various applications, its effect on osteogenesis has not yet been investigated. In this study, we synthesized MgB2 nanosheets (MgB2NS), a new class of 2D-nanoscale structures, by the ultrasonication exfoliatio...
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#1A.S. SoubhagyaH-Index: 1
#2K. BalagangadharanH-Index: 10
Last. Mani PrabaharanH-Index: 32
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Three-dimensional (3D) porous films based on chitosan (CS)/carboxymethyl guar gum (CMGG) polyelectrolyte complex (PEC) containing titanium dioxide nanoparticles (TiO2 NPs) were prepared as a wound-healing material by the freeze-drying process. The physicochemical properties of these films were evaluated by FTIR, XRD, SEM and EDX analysis. Furthermore, the swelling degree, porosity, in vitro biodegradation and compression strength of these films were examined. The developed films showed the bioco...
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Abstract Bone is a highly integrative and dynamic tissue of the human body that is regularly modeled and remodeled by bone cells such as osteoblasts and osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale, but in a dilatory manner. To overcome this problem, the field of bone tissue engineering (BTE) utilizes various bio-composite scaffolds that incorporate ce...
2 CitationsSource
Abstract Veratric acid (3,4-dimethoxy benzoic acid) (VA) is a hydrophobic phenolic phytocompound possessing therapeutic potential, but it has not been reported as actuating bone regeneration to date. Furthermore, delivery of hydrophobic compounds is often impeded in the body, thus depreciating their bioavailability. In this study, VA was found to have osteogenic potential and its sustained delivery was facilitated through a nanoparticle-embedded coaxial electrospinning technique. Polycaprolacton...
6 CitationsSource
Abstract Recently, polymer based biomaterials are utilized in medical fields including surgical sutures, drug delivery devices, tissue supports and implants for interior bone fixation. However, polymer based implants leads to the formation of bio-films that are highly susceptible to microbial adhesion. In this study, we have fabricated Chitosan/Polyvinyl alcohol/Graphene oxide/Hydroxyapatite/gold films for potential orthopedic application. Graphene oxide/Hydroxyapatite/gold nanocomposite (GO/HAP...
16 CitationsSource
#1Ganesh Sanjeev (SRM University)H-Index: 2
#1Ganesh SanjeevH-Index: 1
Last. Nagarajan SelvamuruganH-Index: 59
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Abstract In recent years, phytochemicals have been widely researched and utilized for the treatment of various medical conditions such as cancer, cardiovascular diseases, age-related problems and are also said to have bone regenerative effects. In this study, phytol (3, 7, 11, 15-tetramethylhexadec-2-en-1-ol), an acyclic unsaturated diterpene alcohol and a secondary metabolite derived from aromatic plants was investigated for its effect on osteogenesis. Phytol was found to be nontoxic in mouse m...
4 CitationsSource
Abstract Spontaneous bone regeneration is heavily restricted because of bone defects, and external mediation is required to enhance repair and regeneration. Bone tissue engineering (BTE) is a multidisciplinary field that offers promising substitutes to traditional methods—namely, autografts, allografts, and xenografts. Amidst the various scaffolds for BTE applications, it has been demonstrated that hydrogels are promising templates for bone regeneration owing to their similarities to the natural...
12 CitationsSource
Abstract Fractures and injuries pertaining to bone tissue usually take prolonged periods for its natural healing. To overcome this problem, the field of bone tissue engineering (BTE) has acquired an efficient designing mechanism that incorporates cells, biomaterials and the corresponding growth factors to promote both osteogenesis as well as mineralization of the bone. Amidst the various techniques available for scaffold creation, electrospinning is considered superior as it paves the way for th...
45 CitationsSource
#1K. BalagangadharanH-Index: 10
#2Ritu Trivedi (CSIR: Council of Scientific and Industrial Research)H-Index: 27
Last. Nagarajan SelvamuruganH-Index: 59
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Abstract Sinapic acid (SA) is a plant-derived phenolic compound known for its multiple biological properties, but its role in the promotion of bone formation is not yet well-studied. Moreover, the delivery of SA is hindered by its complex hydrophobic nature, limiting its bioavailability. In this study, we fabricated a drug delivery system using chitosan nanoparticles (nCS) loaded with SA at different concentrations. These were incorporated into polycaprolactone (PCL) fibers via an electrospinnin...
20 CitationsSource
#2K. BalagangadharanH-Index: 10
Last. Nagarajan SelvamuruganH-Index: 59
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: Zingerone, 4-(4-hydroxy-3-methoxyphenyl)-2-butanone (Zg), a phenolic compound isolated from ginger is reported to have anti-inflammatory and antidiabetic properties. However, its role in the promotion of osteogenesis is not known. In this study, we investigated the therapeutic effect of Zg on osteogenesis at the cellular and molecular levels. Zg treatment was nontoxic to mouse mesenchymal stem cells (mMSCs). At the cellular level, it enhanced osteoblast differentiation as evidenced by more cal...
8 CitationsSource