Fl Dente
University of Pisa
AirwayInternal medicineImmunologyAllergyPlaceboAsthmaRespiratory diseaseBronchial hyperresponsivenessSputumInhalationEosinophilOccupational asthmaAllergenBronchoconstrictionMethacholineHypertonic salineAnesthesiaMedicinePulmonary function testingEosinophil cationic proteinGastroenterology
53Publications
19H-index
924Citations
Publications 53
Newest
To determine whether inhaled budesonide given after allergen inhalation challenge inhibits the late asthmatic response (LAR) and/or the associated increase of airway responsiveness to methacholine, we performed a double-blind randomized cross-over study in 12 adult asthmatics (eight male, four female; mean age, 20.3 yr; range, 18 to 29 yr) sensitized to Dermatophagoides pteronyssinus (DP) previously shown to develop early and late asthmatic response to allergen challenge with DP. On different da...
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#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
#2Barbara VagagginiH-Index: 29
Last. Carlo GiuntiniH-Index: 46
view all 9 authors...
Several studies on the prognosis of occupational asthma have shown that a significant proportion of patients continue to experience asthmatic symptoms and nonspecific bronchial hyperresponsiveness after cessation of work. The determinants of this unfavourable prognosis of asthma are: long duration of exposure before the onset of asthma; long duration of symptoms before diagnosis; baseline airway obstruction; dual response after specific challenge test; and the persistence of markers of airway in...
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: In order to investigate if bronchial asthma is associated with enhanced markers of activation in peripheral neutrophils, the migratory capacity of neutrophils in venous blood was measured by means of the Boyden chamber technique in 29 subjects with bronchial asthma of differing severity. Random migration (random motility), but not locomotion toward 10% Escherichia coli supernatant as chemoattractant (chemotaxis), was increased in asthmatic subjects with respect to 11 normal subjects (98 +/- 20...
#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
#2Barbara Vagaggini (UniPi: University of Pisa)H-Index: 29
Last. Carlo Giuntini (UniPi: University of Pisa)H-Index: 46
view all 9 authors...
Long-term change in nonspecific and specific bronchial hyperresponsiveness was studied in 16 subjects with asthma induced by toluene diisocyanate (TDI). A significant positive correlation between months of follow-up and provocative dose inducing a 20 percent fall in FEV 1 (PD 20 FEV 1 ) methacholine was observed in 5 of 16 subjects. In 4 of these 5 subjects, a PD 20 FEV 1 >1 mg of methacholine was observed 30 to 48 months after the end of TDI exposure. In most subjects, nonspecific bronchial hyp...
Source
#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
#2Fl Dente (UniPi: University of Pisa)H-Index: 19
Last. Carlo Giuntini (UniPi: University of Pisa)H-Index: 46
view all 10 authors...
Abstract Salbutamol is known to effectively prevent early asthmatic response (EAR) after specific bronchial provocation test (sBPT) in asthmatic subjects, but the time-course of this protection is not known. In this study the effects of 200 μg salbutamol inhaled 2 h before sBPT were compared with 200 μg salbutamol inhaled 10 min before sBPT in eight asthmatic subjects sensitized to Phleum pratensis (PP) or Dermatophagoides pteronyssinus (DP). All subjects showed an EAR (% decrease in FEV 1 from ...
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#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
#2Fl Dente (UniPi: University of Pisa)H-Index: 19
Last. Carlo Giuntini (UniPi: University of Pisa)H-Index: 46
view all 9 authors...
The effect of a week treatment with inhaled salbutamol plus placebo (S+P) vs. salbutamol combined with beclomethasone dipropionate (S+BDP) on early and late asthmatic responses to inhaled allergen was studied in ten atopic patients in a randomized, double-blind, cross-over study. All patients had previously shown a dual type response to the specific bronchial provocative test (sBPT). Each patient performed two periods of treatment for a week, with a 15 day interval between them: (a) salbutamol 0...
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#1D TaliniH-Index: 13
#2Barbara VagagginiH-Index: 29
Last. Fl DenteH-Index: 19
view all 6 authors...
Source
#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
#2Fl Dente (UniPi: University of Pisa)H-Index: 19
Last. Carlo Giuntini (UniPi: University of Pisa)H-Index: 46
view all 6 authors...
In order to evaluate the pattern of airway response to a specific bronchial provocative test (sBPT) with an extract of Phleum pratensis standardized in biological units (BU), we studied 27 patients with seasonal asthma due to grass pollen by means of allergologic evaluations, methacholine inhalation test and sBPT, outside the pollen season in all patients and, in 10 of them, also during the pollen season. We used a DeVilbiss 646 nebulizer with a dosimeter, giving increasing doses (0.01–2.5 BU) o...
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: Although vagal reflexes are well documented in animal models of airway hyperresponsiveness, their importance in asthmatic attacks in man is less documented. Indeed most of the stimuli that can trigger bronchoconstriction act only partially through a cholinergic reflex. However, inflammatory mediators released in airways during asthma attacks may stimulate different sites of cholinergic pathways, i.e. in the sensory receptors, afferent, efferent, ganglionic or postganglionic sites. Further stud...
#1Elena BacciH-Index: 27
#2Pierluigi PaggiaroH-Index: 55
Last. Carlo GiuntiniH-Index: 46
view all 7 authors...
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