Dwaipayan Bhattacharya
Indian Institute of Chemical Technology
CytotoxicityNeuriteNanomedicineDNA vaccinationNeuroscienceLiposomeChemistryMaterials scienceIn vitroIn vivoNeuroprotectionEx vivoZebrafishMelanomaGliomaSTAT3Drug deliveryCancer researchMedicinePI3K/AKT/mTOR pathwayNeurotrophinCancer cellPharmacology
16Publications
5H-index
96Citations
Publications 16
Newest
#1Namita S. Mahadik (Indian Institute of Chemical Technology)
#2Dwaipayan Bhattacharya (BITS: Birla Institute of Technology and Science)H-Index: 5
Last. Rajkumar Banerjee (Indian Institute of Chemical Technology)H-Index: 24
view all 6 authors...
The steroid hormone receptors (SHRs) among nuclear hormone receptors (NHRs) are steroid ligand-dependent transcription factors that play important roles in the regulation of transcription of genes promoted via hormone responsive elements in our genome. Aberrant expression patterns and context-specific regulation of these receptors in cancer, have been routinely reported by multiple research groups. These gave an window of opportunity to target those receptors in the context of developing novel, ...
Source
#1Bommana Raghunath Reddy (Indian Institute of Chemical Technology)H-Index: 4
#2Nukala Sarath Babu (CCMB: Centre for Cellular and Molecular Biology)H-Index: 3
Last. Sumana Chakravarty (Indian Institute of Chemical Technology)H-Index: 33
view all 8 authors...
Debilitating mental illness like depression and related mood disorders is due to the disruption in circuitry that controls emotion, motivation, and reward, characterized by disparate phenotypes like decrease in socialization, motivation, the threshold for threat apprehension, etc. Chronic stress is a major factor in the etiology of these disorders. Here, using a Chronic Unpredictable Stress (CUS) paradigm the characterization of an array of mood disorder phenotypes in adult zebrafish, in compari...
2 CitationsSource
#1Dwaipayan Bhattacharya (BITS: Birla Institute of Technology and Science)H-Index: 5
#2Kalyani Sakhare (BITS: Birla Institute of Technology and Science)
Last. Rajkumar Banerjee (Indian Institute of Chemical Technology)H-Index: 24
view all 4 authors...
Abstract OSCC (Oral Squamous Cell Carcinoma) is currently one of the most formidable cancers plagued by challenges like low overall survivability, lymph node associated metastasis, drug resistance, and poor diagnostics. The tumor microenvironment (TME) and its constituent stromal elements are crucial modulators of tumor growth and treatment response. Interestingly, there isn’t much information on TAM-targeted nanotherapy in OSCC where the first line of therapeutics for oral cancer is surgery wit...
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#1Sudip Mukherjee (Rice University)H-Index: 24
#2Vijay Sagar Madamsetty (Mayo Clinic)H-Index: 8
Last. Anubhab MukherjeeH-Index: 13
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19 CitationsSource
#1Sudip Mukherjee (Indian Institute of Chemical Technology)H-Index: 24
#2Rajesh Kotcherlakota (Indian Institute of Chemical Technology)H-Index: 11
Last. Chitta Ranjan Patra (Indian Institute of Chemical Technology)H-Index: 42
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Abstract Efficient delivery of chemotherapeutic drugs to tumor cells is one of the crucial issues for modern day cancer therapy. In this article, we report the synthesis of poly ethylene glycol (PEG) assisted colloidal platinum nanoparticles (PtNPs) by borohydride reduction method at room temperature. PtNPs are stable at room temperature for more than 2 years and are stable in serum and phosphate buffer (pH = 7.4) solution for one week. PtNPs show biocompatibility in different normal cell lines ...
19 CitationsSource
#1Ayan Kumar Barui (Indian Institute of Chemical Technology)H-Index: 17
#2Priya Jhelum (Indian Institute of Chemical Technology)H-Index: 6
Last. Chitta Ranjan Patra (Indian Institute of Chemical Technology)H-Index: 42
view all 9 authors...
Neuritogenesis, a complex process of the sprouting of neurites, plays a vital role in the structural and functional restoration of cerebral ischemia-injured neuronal tissue. Practically, there is no effective long-term treatment strategy for cerebral ischemia in clinical practice to date due to several limitations of conventional therapies, facilitating the urgency to develop new alternative therapeutic approaches. Herein, for the first time we report that pro-angiogenic nanomaterials, zinc oxid...
6 CitationsSource
#1Sudip Mukherjee (Indian Institute of Chemical Technology)H-Index: 24
#2Rajesh Kotcherlakota (Indian Institute of Chemical Technology)H-Index: 11
Last. Chitta Ranjan Patra (Indian Institute of Chemical Technology)H-Index: 42
view all 10 authors...
The development of simple, cost effective and advanced multifunctional technology is the need of the hour to combat cancer as well as bacterial infections. There have been reports of silver nanoparticles (AgNPs), silver salts and prussian blue being used for medicinal purposes and are clinically approved. In this context, in the present communication, we incorporated prussian blue (PB) and silver salts (silver nitrate) to develop silver prussian blue analogue nanoparticles (SPBANPs), a new nanom...
12 CitationsSource
#1R. Gajendra Reddy (Indian Institute of Chemical Technology)H-Index: 5
#2Goverdhan Surineni (Indian Institute of Chemical Technology)H-Index: 5
Last. Sumana Chakravarty (Indian Institute of Chemical Technology)H-Index: 33
view all 9 authors...
Small-molecule inhibitors of HDACs (HDACi) induce hyperacetylation of histone and nonhistone proteins and have emerged as potential therapeutic agents in most animal models tested. The established HDACi vorinostat and tubastatin-A alleviate neurodegenerative and behavioral conditions in animal models of neuropsychiatric disorders restoring the neurotrophic milieu. In spite of the neuroactive pharmacological role of HDACi (vorinostat and tubastatin-A), they are limited by efficacy and toxicity. C...
5 CitationsSource
#1Chandra Kumar Elechalawar (Indian Institute of Chemical Technology)H-Index: 5
#2Dwaipayan Bhattacharya (Indian Institute of Chemical Technology)H-Index: 5
Last. Rajkumar Banerjee (Indian Institute of Chemical Technology)H-Index: 24
view all 13 authors...
Glioblastoma multiforme (GBM), the highly invasive form of glioma, exhibits the highest mortality in patients with brain malignancies. Increasing glioma patients' survivability is challenging, as targeting only tumor-associated malignant cells would not reduce the overall aggressiveness of the tumor mass. This is due to the inadequacy in countering pro-proliferative, invasive and metastatic factors released by tumor-mass associated macrophages (TAMs). Hence, strategically, dual targeting both tu...
8 CitationsSource
#1Vidyan Nithyamol Kalappurakkal (Indian Institute of Chemical Technology)H-Index: 1
#2Dwaipayan Bhattacharya (Indian Institute of Chemical Technology)H-Index: 5
Last. Mallavadhani Venkata Uppuluri (Indian Institute of Chemical Technology)H-Index: 3
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: Systematic chemical screening of the leaves of Bruguiera cylindrica, the tree mangrove of Rhizophoraceae family, afforded five single and pure compounds. The structures of the isolated compounds were established by their spectroscopic data as taraxerol (1), 3β-(E)-coumaroyltaraxerol (2), 3β-(Z)-coumaroyltaraxerol (3), β-sitosterol (4), and eicosanol (5). In view of significant accumulation and interesting biological activities, taraxerol (1) was chemically transformed to synthesize a series of...
3 CitationsSource