Jorim J. Tielbeek
VU University Amsterdam
Genome-wide association studyTraitDevelopmental psychologyAssociation (psychology)DemographySingle-nucleotide polymorphismPsychologyHeritabilityTwin studyNeuroscienceGenetic associationComorbidityAggressionConduct disorderPoison controlGeneticsCandidate geneClinical psychologyGenetic correlationMedicineBiology
13Publications
7H-index
265Citations
Publications 13
Newest
#1Jorim J. Tielbeek (VU: VU University Amsterdam)H-Index: 7
#2Emil Uffelmann (VU: VU University Amsterdam)H-Index: 2
Last. Danielle Posthuma (VU: VU University Amsterdam)H-Index: 103
view all 83 authors...
Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Consortium (BroadABC) meta-analyzed data from 25 discovery samples (N=85,359) and five independent replication samples (N = 8,058) with genotypic data and broad measures of ASB. We identified the first significant genetic associations with broad ASB, involving common intronic variants in the fo...
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#1Charleen D. Adams (Beckman Research Institute)H-Index: 7
#2Jorim J. Tielbeek (VU: VU University Amsterdam)H-Index: 7
Last. Brian B. Boutwell (University of Mississippi)H-Index: 27
view all 3 authors...
BACKGROUND. Norm violation, aggression, and antisocial behaviors (ASB) are harmful to society. In times of crisis, such as the current pandemic, individuals with higher antisocial tendencies may subvert efforts to ameliorate social problems. Complicating research on this topic, however, is the fact that variance in both ASB and health traits is partly heritable, suggesting the possibility of genetic correlations between them. METHODS. We characterized the shared polygenic architecture of ASB, Co...
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#1Richard Karlsson Linnér (VU: VU University Amsterdam)H-Index: 13
#2Travis T. Mallard (University of Texas at Austin)H-Index: 12
Last. Jorim J. Tielbeek (VU: VU University Amsterdam)H-Index: 7
view all 29 authors...
Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and have shared genetic liability. We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By pooling data from ~1.5 million people, our approach is statistically more powerful than single-trait analyses and identifies more than 500 ...
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#1Richard Karlsson Linnér (VU: VU University Amsterdam)H-Index: 13
#2Travis T. Mallard (University of Texas at Austin)H-Index: 12
Last. DickH-Index: 1
view all 24 authors...
Abstract Behaviors and disorders related to self-regulation, such as substance use, antisocial conduct, and ADHD, are collectively referred to as externalizing and have a shared genetic liability. We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By pooling data from ~1.5 million people, our approach is statistically more powerful than single-trait analyses and identifies more than 500 genetic loci. The identif...
Source
#1Jorim J. Tielbeek (VU: VU University Amsterdam)H-Index: 7
#2Brian B. Boutwell (UMMC: University of Mississippi Medical Center)H-Index: 27
A widely replicated finding across the behavioral sciences is that antisocial behaviors correlate with an array of health problems. Less clear, however, is the precise nature of this association. There is reason to suspect that a direct causal link exists between incarceration-a consequence of some antisocial behaviors-and certain negative health outcomes, for instance. However, it might be the case that broader phenotypes like antisocial behavior may correlate with certain health and physiologi...
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#1Jorim J. Tielbeek (VU: VU University Amsterdam)H-Index: 7
#2J. C. Barnes (UC: University of Cincinnati)H-Index: 40
Last. Brian B. Boutwell (SLU: Saint Louis University)H-Index: 27
view all 8 authors...
Summary Prior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviours in human and non-human species. Behavioural genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic aetiologies. We use genome-wide association study data to estimate the genetic correlations between various measures of reproductive development (N = 52 776-318 863) and a...
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#1Jorim J. Tielbeek (VU: VU University Amsterdam)H-Index: 7
#2Jacqueline M. Vink (Radboud University Nijmegen)H-Index: 59
Last. Karin J. H. Verweij (Radboud University Nijmegen)H-Index: 29
view all 6 authors...
Background: There is high comorbidity between antisocial behaviour (ASB) and substance use, and twin studies have shown that part of the covariation is due to overlapping genetic influences. Here we used measured genetic effects to estimate the genetic correlations of ASB with nicotine, alcohol, and cannabis use. Methods: We meta-analysed data from two genome-wide association studies for ASB and used existing summary statistics from the largest genome-wide association studies into substance use ...
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#1Jorim J. Tielbeek (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Ada Johansson (Åbo Akademi University)H-Index: 23
Last. Danielle Posthuma (VU: VU University Amsterdam)H-Index: 103
view all 39 authors...
Importance Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified. Objectives To estimate the single-nucleotide polymorphism–based heritability of ASB; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to reevaluate the candidate...
Source
#1Tinca J. C. Polderman (VU: VU University Amsterdam)H-Index: 36
#2Philip Jansen Vrije (VU: VU University Amsterdam)
Last. Tanja G. M. Vrijkotte (UvA: University of Amsterdam)H-Index: 37
view all 6 authors...
#1Jorim J. TielbeekH-Index: 7
#2Ada JohanssonH-Index: 23
Last. Danielle PosthumaH-Index: 103
view all 39 authors...
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