Yu Fu
Sichuan University
CytotoxicityPharmacokineticsTargeted drug deliveryPathologyProinflammatory cytokineBioavailabilityLiposomeChemistryTraditional Chinese medicineMaterials scienceConjugateIn vitroMicrovesiclesIn vivoTransferrinCmaxOxidative stressProstateInflammationPolyethylene glycolCelastrolPaclitaxelRheumatoid arthritisBiodistributionGlucosamineGliomaInflammatory bowel diseaseBlood–brain barrierBlockadeSwellingInsulinCaprolactamDerivative (chemistry)Parkinson's diseaseDrug deliveryKidneyAutoimmunityProstate cancerDexamethasonePolyvinyl acetateSpleenSubstantia nigraPathogenesisTriptolideTargeted therapyDoxorubicinPopulationKidney metabolismAcute Renal InjuryToxicityDisease progressionErythrocyte membraneInsulin deliveryIntravenous glucoseTransferrin receptorChromatographyCancer researchNecrosisDopamineCentral nervous systemIschemiaDiabetes mellitusMedicinePharmacology
9Publications
7H-index
168Citations
Publications 10
Newest
#1Yu Fu (SWU: Southwest University)H-Index: 7
#2Qing Lin (Sichuan University)H-Index: 11
Last. Zhirong Zhang (Sichuan University)H-Index: 63
view all 3 authors...
OBJECTIVE To more precisely estimate the association between the tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene polymorphisms and systemic lupus erythematosus (SLE) susceptibility, we performed a meta-analysis on the association of the following single nucleotide polymorphisms (SNPs) of TNFSF4 with SLE: rs1234315, rs844648, rs2205960, rs704840, rs844644, rs10489265. METHODS A literature-based search was conducted using PubMed, MEDLINE, Embase, Web of Science databases, and Cochr...
Source
Abstract Glioma is one of the most common aggressive brain malignancies, but the treatment of glioma is still far from satisfying. The efficiency of chemotherapy – the major choice of glioma treatment – is severely limited by low chemotherapeutic agents delivery across blood-brain barrier (BBB) and low tumor retention. Therefore, a safe and effective drug delivery system to help chemotherapy agents traverse the BBB and accumulate at tumor sites is urgently needed. Paclitaxel (PTX) is one of the ...
13 CitationsSource
#1Qing Lin (University of Cambridge)H-Index: 2
#2Mengke Qu (Sichuan University)H-Index: 7
Last. Zhirong Zhang (Sichuan University)H-Index: 63
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Abstract Ethnopharmacological relevance Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in anti-tumor therapies. Imperialine is one of the most favored ...
7 CitationsSource
#1Mengke Qu (Sichuan University)H-Index: 7
#2Qing Lin (Sichuan University)H-Index: 11
Last. Xun Sun (Sichuan University)H-Index: 50
view all 11 authors...
Abstract Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, largely because the blood-brain barrier blocks passage of most drugs. Here we find exosomes from blood showing natural brain targeting ability which involved the transferrin-transferrin receptor interaction. Thus, we develop a biocompatible platform based on blood exosomes for delivering drugs across the blood-brain barrier. Blood exosomes show sizes between 40 and 200 nm ...
114 CitationsSource
#1Yu Fu (Sichuan University)H-Index: 7
#2Wei Liu (Sichuan University)H-Index: 3
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 11 authors...
29 CitationsSource
#1Yu Fu (Sichuan University)H-Index: 7
#2Wei Liu (Sichuan University)H-Index: 3
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 11 authors...
1 CitationsSource
#7Lin Li (Sichuan University)
Prostate cancer, one of the leading causes of disease and death in men all over the world, is challenging to treat. α-Enolase, a multifunctional protein, is overexpressed on human prostate carcinoma cells, and thereby it is a potential target for treatment of prostate cancer. In the current study, the pHCT74 peptide was used to construct a kind of highly targeted liposome (pHCT74-lipo) loaded with doxorubicin (pHCT74-lipo-Dox), which specifically targeted α-enolase on prostate tumour cells. Comp...
18 CitationsSource
#1Xun Hu (Sichuan University)H-Index: 2
#2Mengdi Jia (Sichuan University)H-Index: 5
Last. Qing Lin (Sichuan University)H-Index: 11
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: This study aimed to novelly design and synthesize an amide derivative as a potential substitute of celastrol (CLT). We constituted the compound celastrol-glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to celastrol (CLT) and confirmed its chemical structure by 1H NMR, 13C NMR, and LC-MS/MS. Then, the potential efficacy of the CLG was investigated on renal ischemia-reperfusion injury animal models. The results demonstrated that the decorated compound CLG could completely revers...
9 CitationsSource
#1Yu Fu (Sichuan University)H-Index: 7
#2Qing Lin (Sichuan University)H-Index: 11
Last. Zhirong Zhang (Sichuan University)H-Index: 63
view all 5 authors...
Renal-targeting triptolide-glucosamine conjugate exhibits lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats
18 CitationsSource
#1Qing Lin (Sichuan University)H-Index: 11
#2Yu Fu (Sichuan University)H-Index: 7
Last. Zhirong Zhang (Sichuan University)H-Index: 63
view all 7 authors...
Abstract Imperialine, extracted from Bulbus Fritillariae Cirrhosae, is an efficient antitussive and expectorant medicine. However, its short half-life and stomach degradation limited imperialine from further clinical use. The current study was conducted to develop a sustained-release tablet for imperialine both to prolong absorption time and to improve the oral bioavailability of the drug. The tablets were prepared by a direct compression method formulated on optimized solid dispersion (SD) for ...
12 CitationsSource