Fred H. Gage
Salk Institute for Biological Studies
AnatomyInduced pluripotent stem cellInternal medicineEndocrinologyNeural stem cellCellular differentiationHippocampal formationPsychologyNeuroscienceProgenitor cellCholinergicDentate gyrusHippocampusStem cellTransplantationNeurogenesisCentral nervous systemMedicineBiologyCell biology
966Publications
237H-index
165kCitations
Publications 961
Newest
#1Gerald S. Shadel (Salk Institute for Biological Studies)H-Index: 68
#2Peter D. Adams (DI: Discovery Institute)H-Index: 7
Last. Anthony J.A. Molina (UCSD: University of California, San Diego)H-Index: 21
view all 18 authors...
Understanding basic mechanisms of aging holds great promise for developing interventions that prevent or delay many age-related declines and diseases simultaneously to increase human healthspan. However, a major confounding factor in aging research is the heterogeneity of the aging process itself. At the organismal level, it is clear that chronological age does not always predict biological age or susceptibility to frailty or pathology. While genetics and environment are major factors driving va...
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#1Vera Gorbunova (UR: University of Rochester)H-Index: 54
#2Andrei Seluanov (UR: University of Rochester)H-Index: 51
Last. Anna P. Petrashen (Brown University)H-Index: 4
view all 14 authors...
The genomes of virtually all organisms contain repetitive sequences that are generated by the activity of transposable elements (transposons). Transposons are mobile genetic elements that can move from one genomic location to another; in this process, they amplify and increase their presence in genomes, sometimes to very high copy numbers. In this Review we discuss new evidence and ideas that the activity of retrotransposons, a major subgroup of transposons overall, influences and even promotes ...
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#1Stephen T. Johnston (UCSD: University of California, San Diego)H-Index: 6
#2Sarah L. Parylak (Salk Institute for Biological Studies)H-Index: 11
Last. Ondrej Novak (Charles University in Prague)H-Index: 2
view all 13 authors...
Recombinant adeno-associated virus (rAAV) has been widely used as a viral vector across mammalian biology and has been shown to be safe and effective in human gene therapy. We demonstrate that neural progenitor cells (NPCs) and immature dentate granule cells (DGCs) within the adult murine hippocampus are particularly sensitive to rAAV-induced cell death. Cell loss is dose dependent and nearly complete at experimentally relevant viral titers. rAAV-induced cell death is rapid and persistent, with ...
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#1Stephen T. Johnston (UCSD: University of California, San Diego)H-Index: 6
#2Sarah L. Parylak (Salk Institute for Biological Studies)H-Index: 11
Last. Ondrej Novak (Charles University in Prague)H-Index: 2
view all 13 authors...
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#1Kun Tan (UCSD: University of California, San Diego)H-Index: 32
#2Matthew E Kim (UCSD: University of California, San Diego)
Last. Miles F. Wilkinson (UCSD: University of California, San Diego)H-Index: 63
view all 8 authors...
Transposable elements (TEs) are mobile sequences that engender widespread mutations and thus are a major hazard that must be silenced. The most abundant active class of TEs in mammalian genomes is long interspersed element class 1 (LINE1). Here, we report that LINE1 transposition is suppressed in the male germline by transcription factors encoded by a rapidly evolving X-linked homeobox gene cluster. LINE1 transposition is repressed by many members of this RHOX transcription factor family, includ...
1 CitationsSource
#1Gisele Pereira Dias ('KCL': King's College London)H-Index: 13
#2Tytus Murphy ('KCL': King's College London)H-Index: 6
Last. Sandrine Thuret (TUD: Dresden University of Technology)H-Index: 29
view all 11 authors...
Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity and cognition but the effects and mechanisms that differentiate these two paradigms are unknown. We examined whether IF in the form of every-other-day feeding enhances cognition and adult hippocampal neurogenesis (AHN) when compared to a matched 10% daily CR intake and ad libitum conditions. After 3 months under IF, female C57BL6 mice exhibited improved long-term memory retention. IF increased the number of BrdU-label...
1 CitationsSource
#1Simon T. Schafer (Salk Institute for Biological Studies)H-Index: 13
#2Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder that is thought to emerge very early in development. Cerebral overgrowth, which is clinically referred to as macrocephaly, is frequently observed in children with ASD, and brain imaging studies have reported increases in both gray- and white-matter volume (1⇓⇓⇓⇓–6). Children with these early signs of brain enlargement have been shown to be part of an ASD group with high probability of receiving a diagnosis (3, 5⇓–7)...
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#1Jerome Mertens (Salk Institute for Biological Studies)H-Index: 21
#2Joseph R. Herdy (Salk Institute for Biological Studies)H-Index: 7
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
view all 25 authors...
Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age-equivalent neuronal model. AD patient-derived iNs exhibit strong neuronal transcriptome signatures characterized by downregulation of mature neuronal properties and upregulation of immature and progenitor-like signaling pathways. Mapping iNs to longitudinal neuronal differentiation trajectory data demonstrated that AD iNs reflect ...
2 CitationsSource
#1Martin Thunemann (BU: Boston University)H-Index: 15
#1Martin Thunemann (BU: Boston University)H-Index: 1
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
view all 13 authors...
We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.
#1Dylan A. Reid (Salk Institute for Biological Studies)H-Index: 13
#2Patrick J. Reed (Salk Institute for Biological Studies)H-Index: 2
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 237
view all 22 authors...
Neurons are the longest-lived cells in our bodies and lack DNA replication, which makes them reliant on a limited repertoire of DNA repair mechanisms to maintain genome fidelity. These repair mechanisms decline with age, but we have limited knowledge of how genome instability emerges and what strategies neurons and other long-lived cells may have evolved to protect their genomes over the human life span. A targeted sequencing approach in human embryonic stem cell-induced neurons shows that, in n...
2 CitationsSource