Tsutomu Kimura
Daiichi Sankyo
AntigenAntibodyPenicillinChemistryImmunologyPrimary and secondary antibodiesStreptomycinAmpicillinT cellBenzylpenicillinSubcutaneous injectionKeyhole limpet hemocyaninCefazolinGuinea pigCarbenicillinImmunosuppressionToxicityBiologyImmune system
Publications 3
#1Ryota KawaiH-Index: 4
#2Shiho ItoH-Index: 1
Last. Teruo Kawada (Kyoto University)H-Index: 64
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To develop a rat T-cell-dependent antibody response (TDAR) model evaluating both primary and secondary antibody responses, keyhole limpet hemocyanin (KLH) was used to immunize rats twice during a 14-day course of study, a pattern closely linked to that of a short-term general toxicity study. Female rats of four representative strains (e.g., Sprague-Dawley, Wistar, Fischer, and Lewis) were immunized twice with intravenous administrations of KLH (300 µg/rat) on Days 5 and 9 during a 14-day treatme...
18 CitationsSource
#1Tetsuo AidaH-Index: 6
#2Ryota KawaiH-Index: 4
Last. Tadashi FurukawaH-Index: 8
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#1Tetsuo AidaH-Index: 6
#2Tsutomu KimuraH-Index: 2
Last. Kenkichi ShinkaiH-Index: 4
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In the present study, the correlation between mouse PLNA and those obtained from GP-PCA and from GP-ASA reactions fro sodium 2, 4, 6-trinitrobenzenesulfonate dihydrate (TNBS), penicillin G and cephalothin was investigated. Next, variou drugs were tested using the mouse PLNA to study whether PLN reactivity could be related to the potential of the compounds to induce allergic and autoimmune disorders in humans. The parameter of the PLNA was determined by the PLN cellularity index in BALB/c and A/J...
13 CitationsSource