Zhongzheng Zhou
Ocean University of China
Composite numberSelf-healing hydrogelsCytotoxicityBiophysicsFabricationNuclear chemistryAntigenResponse surface methodologyNanoparticleFourier transform infrared spectroscopyAbsorption of waterBox–Behnken designRegeneration (biology)NanocarriersLiposomeChemistryPolymer chemistryMaterials scienceMesenchymal stem cellTransdermalIn vivoBiocompatibilityImmunotherapySwellingLymphChitosanAmmoniumHemolysisAntibacterial activityWound healingChitinChemical engineeringTransfersomeCancer researchSodiumBiofilmThermal stabilityMineralization (biology)Bone healingAdhesionImmune system
23Publications
11H-index
308Citations
Publications 23
Newest
#1Mengyang Wang (Ocean University of China)H-Index: 2
#2Bi ShichaoH-Index: 1
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 8 authors...
Abstract In the present research, nutrient broth (NB) medium was identified to be able to neutralize the antibacterial activity of chitosan and its derivatives. Therefore, an improved test method independent of NB medium was proposed to precisely quantify the antibacterial effectiveness and efficiency of chitosan. The minimum bactericidal concentration (MBC) of chitosan was 60 μg mL−1 against S. aureus and E. coli, and 0.01 % (w/v) chitosan could kill 100 % of bacteria within 3 min. From another...
2 CitationsSource
#1Shichao BiH-Index: 9
#2Pengjun Wang (Qingdao University)H-Index: 3
Last. Xiguang ChenH-Index: 61
view all 11 authors...
2 CitationsSource
#1Wei Wu (Ocean University of China)H-Index: 1
#2Zhongzheng Zhou (Ocean University of China)H-Index: 11
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 6 authors...
Abstract As a framework for tissue engineering regeneration, the characteristics of cell scaffold materials directly affect cell adhesion, migration and metabolism. In this study, we have fabricated decellularized and decalcified fish scale-derived scaffolds and determined its basic physicochemical properties to serve as cell scaffolds in tissue engineering. Scanning electron microscopy (SEM) results showed that there were radial grooves and ring ridges on the surface of the scale-derived scaffo...
Source
#1Zhongzheng Zhou (Ocean University of China)H-Index: 11
#2Jianhui Pang (Ocean University of China)H-Index: 9
Last. Ming Kong (Ocean University of China)H-Index: 27
view all 6 authors...
The maturation of dendritic cells (DCs) and infiltration effector T cells in tumor-draining lymph node (tdLN) and tumor tissue are crucial for immunotherapy. Despite constructive progresses have been made with anti-programmed death-1 (anti-PD1) checkpoint blockade for immunotherapy, the efficacy of PD1/PD-L1 therapy deserves to be improved. Here, we constructed a novel transfersomes based nanovaccine complexed microneedles to enhance anti-PD1 immunotherapy via transdermal immunization for skin t...
16 CitationsSource
#1Jianhui Pang (Ocean University of China)H-Index: 9
#2Shichao Bi (Ocean University of China)H-Index: 9
Last. Ming Kong (Ocean University of China)H-Index: 27
view all 9 authors...
Abstract Schiff base reaction crosslinking hydrogels are advantageous by rapid formation and absence of external crosslinkers. However, poor mechanical hindered their broader applications. Here, a mechanically strengthened tissue adhesive was constructed through incorporation of chitin nano-whiskers (CtNWs) with a Schiff base crosslinking hydrogel of carboxymethyl chitosan (CMCS) and dextran dialdehyde (DDA). The optimal formulation of complexed hydrogel exhibited 1.87 folds higher compressive s...
19 CitationsSource
#1Xin Luo (Ocean University of China)H-Index: 3
#2Liu Yidan (Ocean University of China)H-Index: 1
Last. Ming Kong (Ocean University of China)H-Index: 27
view all 9 authors...
Abstract Stimuli-responsive gel volume variation is reversible and has shown promising applications, which may be potential for contraction or expansion fabrication, generating shrinking or swelling volume of the original. In this study, a thermo/photo dual-crosslinking hydrogel is prepared with methacrylated hydroxylbutyl chitosan (MHBC) and gelatin methacrylate (GelMA). The M/G hydrogel undergoes sol-gel phase transition under room temperature and shrinking deformation upon elevating temperatu...
8 CitationsSource
#1Xuqian Lang (Ocean University of China)H-Index: 7
#2Yang Li (CAU: University of Kiel)H-Index: 13
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 10 authors...
Uniform molecular weight (Mw) chitosan (CS) is highly demanded in medical biomaterial industry. This present article described heterogeneous degradation of CS in aqueous HCl/ethanol solution, in which progress uniform Mw CS was successfully prepared. The Mw distribution of CS was measured by gel permeation chromatography (GPC) analysis. Moreover, the structure and properties of degraded CS were characterized by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectrosc...
Source
#1Shichao Bi (Ocean University of China)H-Index: 9
#2Pengjun Wang (Qingdao University)H-Index: 1
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 11 authors...
Abstract Weak mechanical properties, lack biocompatibility and relatively bioinert are formidable obstruct in application of bone repair materials. Multifunctional composite materials have been considered as a viable solution to this problem. Here, a new double network (DN) hydrogel was constructed by physical cross-linking of medical grade poly (vinyl alcohol) (PVA) and chitosan in KOH/urea dissolution system. The obtained hydrogel demonstrated excellent tensile strength (0.24 MPa), elongation ...
35 CitationsSource
#1Xuanjin Wu (Ocean University of China)H-Index: 5
#2Yang Li (Ocean University of China)H-Index: 13
Last. Ming Kong (Ocean University of China)H-Index: 27
view all 7 authors...
The efficient delivery of vaccines to draining lymph nodes and the induction of robust local immune responses are crucial for immunotherapy. Transdermal administration has been evidenced to facilitate the delivery of ingredients to lymph nodes. In this study, transfersomes with opposite surface charges were applied for antigen encapsulation and these were integrated with dissolving microneedles to investigate their effects on immune responses via transdermal immunization. The microneedles were e...
13 CitationsSource
#1Fang Hu (Qingdao University)H-Index: 4
#2Zhongzheng Zhou (Ocean University of China)H-Index: 11
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 9 authors...
Abstract The aim of this study was to evaluate the antibacterial activity and cytocompatibility of novel pH-activated nanoparticles (NPs) in vitro and in vivo. The NPs were synthesized from a quaternary ammonium chitosan, i.e., N,N,N-trimethyl chitosan, a liposome, and doxycycline (TMC-Lip-DOX NPs). The cytocompatibility of the NPs was evaluated. The TMC-Lip-DOX NPs achieved superb inhibition of free mixed bacteria and biofilm formation. They also showed excellent biocompatibility with human per...
26 CitationsSource