Mario Alberto Pérez-Díaz
Instituto Politécnico Nacional
Self-healing hydrogelsBiocompatible materialDrug carrierBiomedical engineeringNuclear chemistryCytotoxic T cellFourier transform infrared spectroscopyControlled releaseRegeneration (biology)MicroorganismMinimum inhibitory concentrationBacterial growthSerial dilutionChemistryExtracellular matrixMaterials scienceTransdermalCombinatorial chemistryScanning electron microscopeAmpicillinGram-negative bacteriaStenotrophomonas maltophiliaSilver sulfadiazineBiocompatibilityHuman skinHyaluronic acidPseudomonas aeruginosaEnterococcus faeciumStaphylococcus epidermidisAntioxidantBiomaterialStreptococcus mutansPolyvinyl alcoholStaphylococcus aureusGram-positive bacteriaChitosanDrug deliveryPolyvinylpyrrolidoneWound healingMicrobial resistanceConcentration dependentSilver nanoparticleDifferential scanning calorimetryChemical engineeringAntimicrobialTissue engineeringAntibioticsPolymerBacteriaViability assayBiofilmThermogravimetric analysisAdhesionMicrobiology
9Publications
5H-index
128Citations
Publications 9
Newest
#1Fernanda Kamila Godoy-Alvarez (UNAM: National Autonomous University of Mexico)
Last. Gerardo Leyva-Gómez (UNAM: National Autonomous University of Mexico)H-Index: 12
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Hyaluronic acid (HA) is one of the most attractive natural polymers employed in biomaterials with biological applications. This polysaccharide is found in different tissues of the body because it is a natural component of the extracellular matrix; furthermore, it has crucial functions in cell growth, migration, and differentiation. Since its biological characteristics, HA has been utilized for the new biomaterial’s development for tissue engineering, such as hydrogels. These hydrophilic macromol...
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#1María L. Del Prado-Audelo (UNAM: National Autonomous University of Mexico)H-Index: 7
#2Francisco J. Gómez-Zaldivar (UNAM: National Autonomous University of Mexico)
Last. Gerardo Leyva-Gómez (UNAM: National Autonomous University of Mexico)H-Index: 12
view all 11 authors...
The purpose of our study was to obtain new wound dressings in the form of hydrogels that promote wound healing taking advantage of the broad activities of elastin (ELT) in physiological processes. The hydrogel of ELT and polyvinylpyrrolidone (PVP; ELT–PVP) was obtained by cross-linking induced by gamma irradiation at a dose of 25 kGy. The physicochemical changes attributed to cross-linking were analyzed through scanning electron microscopy (SEM), infrared spectroscopy analysis with Fourier trans...
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#1Montserrat Lopez-Carrizales (Universidad Autónoma de San Luis Potosí)H-Index: 2
#2E. Mendoza-Mendoza (Universidad Autónoma de San Luis Potosí)H-Index: 7
Last. Fidel Martinez-Gutierrez (Universidad Autónoma de San Luis Potosí)H-Index: 13
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Abstract The purpose of this study was to generate novel chitosan hydrogels (CHs) loaded with silver nanoparticles (AgNPs) and ampicillin (AMP) to prevent early formation of biofilms. AgNPs and CHs were characterized by UV-Vis, DLS, TEM, rheology, FT-IR, Raman, and SEM. The antibiofilm effect of the formulations was investigated against four multidrug-resistant and extensively drug-resistant pathogens using a colony biofilm, a high cell density and gradients model. Also, their hemostatic propert...
1 CitationsSource
#1Génesis Osorio-Toribio (UNAM: National Autonomous University of Mexico)H-Index: 1
#2Miriam de J. Velásquez-Hernández (Graz University of Technology)H-Index: 5
Last. Ilich A. Ibarra (UNAM: National Autonomous University of Mexico)H-Index: 25
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Summary The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells) and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way towards the extended use ...
2 CitationsSource
#1Marco Antonio Reyes-Torres (Universidad Autónoma de San Luis Potosí)H-Index: 1
#2E. Mendoza-Mendoza (Universidad Autónoma de San Luis Potosí)H-Index: 7
Last. Fidel Martinez-Gutierrez (Universidad Autónoma de San Luis Potosí)H-Index: 13
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Abstract CuO and ZnO nanoparticles (NPs) were synthesized at room-temperature following a novel, direct, high-yield (>91%) and green method based on a mechanically activated metathesis reaction. The CuO-NPs exhibited a rod-like shape with average length and diameter of 22 and 6 nm, respectively, while the ZnO-NPs showed spherical-like morphology and mean diameter of 15 nm, as determined by TEM. The antimicrobial properties of the NPs and commercially available micrometric counterparts were evalu...
5 CitationsSource
#1Mario Alberto Pérez-Díaz (IPN: Instituto Politécnico Nacional)H-Index: 5
#1Mario Alberto Pérez-Díaz (IPN: Instituto Politécnico Nacional)H-Index: 2
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Background Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-r...
7 CitationsSource
#1Elizabeth Alvarado-Gomez (Universidad Autónoma de San Luis Potosí)H-Index: 4
#2Mario Alberto Pérez-Díaz (Universidad Autónoma de San Luis Potosí)H-Index: 5
Last. Fidel Martinez-Gutierrez (Universidad Autónoma de San Luis Potosí)H-Index: 13
view all 7 authors...
Abstract A biofilm is a very complex consortium formed by a mix of different microorganisms, which have become an important health problem, because its formation is a resistance mechanism used by bacteria against antibiotics or the immune system. In this work, we show differences between some physicochemical properties of biofilms in mono- and multi-species, formed by bacteria from clinical samples of infected chronic wounds. Of the most prevalent bacteria in wounds, two mono- and one multi-spec...
3 CitationsSource
#1Mario Alberto Pérez-Díaz (Universidad Autónoma de San Luis Potosí)H-Index: 5
#2Elizabeth Alvarado-Gomez (Universidad Autónoma de San Luis Potosí)H-Index: 4
Last. Fidel Martinez-Gutierrez (Universidad Autónoma de San Luis Potosí)H-Index: 13
view all 10 authors...
The development of multi-species biofilms in chronic wounds is a serious health problem that primarily generates strong resistance mechanisms to antimicrobial therapy. The use of silver nanoparticles (AgNPs) as a broad-spectrum antimicrobial agent has been studied previously. However, their cytotoxic effects limit its use within the medical area. The purpose of this study was to evaluate the anti-biofilm capacity of chitosan gel formulations loaded with AgNPs, using silver sulfadiazine (SSD) as ...
54 CitationsSource
#1Mario Alberto Pérez-Díaz (Universidad Autónoma de San Luis Potosí)H-Index: 5
#2Laura Boegli (MSU: Montana State University)H-Index: 6
Last. Fidel Martinez-Gutierrez (Universidad Autónoma de San Luis Potosí)H-Index: 13
view all 8 authors...
Abstract Microbial resistance represents a challenge for the scientific community to develop new bioactive compounds. The goal of this research was to evaluate the antimicrobial activity of silver nanoparticles (AgNPs) against a clinical isolate of Streptococcus mutans , antibiofilm activity against mature S. mutans biofilms and the compatibility with human fibroblasts. The antimicrobial activity of AgNPs against the planktonic clinical isolate was size and concentration dependent, with smaller ...
51 CitationsSource