Yuka Sugawara
University of Tokyo
GeneEpidemiologyComplement systemBiobankInternal medicineUrologyEthnic groupPublic healthFactor HResearch ethicsRecombinationAntibodyAutoantibodyInfection controlEmergency medicineImmunologyGenetic analysisFibrin degradation productSiblingApheresisFibrinolysisUmbilical cordAtypical hemolytic uremic syndromeThrombotic microangiopathyHemodialysisPartial thromboplastin timeFocal segmental glomerulosclerosisKidney diseaseDisseminated intravascular coagulationLDL apheresisNephrotic syndromeAntithrombinFibrinogenMEDLINEMendelian randomizationDialysisUrineGlomerulopathyBody mass indexPersonal protective equipmentThrombosisPathogenesisIsolation (health care)Complement (complexity)Umbilical Cord Blood TransplantationGenomic Structural VariationTransplantationEarly detectionCoronavirus disease 2019 (COVID-19)Nationwide surveyGene clusterCertificationRisk factorFamily medicineDNA sequencingGeneticsNephrologyQuestionnaireInformed consentComputational biologyMedicineBiologyMicrobiologyPlateletPandemicGastroenterology
12Publications
1H-index
6Citations
Publications 13
Newest
#1Hajime Nagasu (Kawasaki Medical School)H-Index: 12
#2Yuichiro Yano (Duke University)H-Index: 67
Last. Jun Wada (Okayama University)H-Index: 63
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OBJECTIVE null Randomized controlled trials have shown kidney-protective effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors, and clinical practice databases have suggested that these effects translate to clinical practice. However, long-term efficacy, as well as whether the presence or absence of proteinuria and the rate of estimated glomerular filtration rates (eGFR) decline prior to SGLT2 inhibitor initiation modify treatment efficacy among type 2 diabetes mellitus (T2DM) and chronic...
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Background: The chronic kidney disease (CKD) public health burden has not declined as expected with current interventions on treatments focusing only on the disease. This study aims to systematically estimate the causal roles of cardiometabolic risk factors on CKD in Europeans and East Asians using Mendelian randomization (MR). Methods: A total of 45 risk factors with genetic data in Europeans and 17 risk factors in East Asians were identified as exposures from PubMed. A total of 51,672 CKD case...
#1Yuka Sugawara (UTokyo: University of Tokyo)H-Index: 1
#2Masao Iwagami (Lond: University of London)H-Index: 9
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
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BACKGROUND: There are no reports of a large-scale survey on the infection prevention measures against coronavirus disease 2019 (COVID-19) in nephrology facilities. This study investigated the facility-level nephrology practices adopted during the COVID-19 pandemic and their associated challenges. Additionally, the treatment patterns and outcomes of chronic kidney disease (CKD) patients with COVID-19 were reviewed. METHODS: We conducted a nationwide questionnaire survey of 704 educational facilit...
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Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic affecting a variety of medical treatments, including hemodialysis. This study aims to investigate the implementation of infection control measures, to examine the shortage of personal protective equipment (PPE) and disinfectants, and to quantify the number of nosocomial COVID-19 transmissions in hemodialysis facilities in Japan during the pandemic. ...
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#1Yuta Fukuchi (Niigata University)
#2Masahiro Kaneko (Niigata University)H-Index: 2
Last. Yoichiro Ikeda (UTokyo: University of Tokyo)H-Index: 4
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#5Yuka Sugawara (UTokyo: University of Tokyo)
Abstract BACKGROUND The chronic kidney disease (CKD) public health burden is substantial and has not declined as expected with current interventions on disease treatments. A large number of clinical, biological, and behavioural risk factors have been associated with CKD. However, it is unclear which of them are causal. OBJECTIVE To systematically test whether previously reported risk factors for CKD are causally related to the disease in European and East Asian ancestries. DESIGN Two-sample Mend...
1 CitationsSource
#1Madoka Fujisawa (UTokyo: University of Tokyo)H-Index: 3
#2Atsushi Yasumoto (UTokyo: University of Tokyo)H-Index: 13
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
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Atypical haemolytic uremic syndrome (aHUS) is associated with complement system abnormality, such as production of complement factor H (CFH) autoantibodies. The growing evidence indicates complement overactivation on platelets is intimately involved in aHUS pathogenesis, besides endothelial injury. We here showed plasma from patients with anti-CFH antibodies induced aggregation of washed platelets, while purified anti-CFH antibodies suppressed aggregation. This suggested anti-CFH antibody itself...
2 CitationsSource
#1Satoko Sakurai (UTokyo: University of Tokyo)H-Index: 3
#2Hideki Kato (UTokyo: University of Tokyo)H-Index: 24
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
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AIM: Atypical hemolytic uremic syndrome (aHUS), characterized by thrombotic microangiopathy (TMA), is a genetic, life-threatening disease which needs many differential diagnoses. This study aimed to reveal coagulation and fibrinolysis profiles in aHUS and secondary TMA patients. Furthermore, we investigated whether aHUS patients progress to, and meet, disseminated intravascular coagulation (DIC) criteria. METHODS: The acute phase samples were available in 15 aHUS and 20 secondary TMA patients. W...
5 CitationsSource
#1Yuka Sugawara (UTokyo: University of Tokyo)H-Index: 1
#2Hideki Kato (UTokyo: University of Tokyo)H-Index: 24
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
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#1Yuka SugawaraH-Index: 1
#2Hideki KatoH-Index: 24
Last. Masaomi NangakuH-Index: 80
view all 7 authors...
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