Romina Hernández
Pontifical Catholic University of Chile
Endothelial stem cellInternal medicineEndocrinologyCytoskeletonPathologyGlycationProinflammatory cytokineChemistryRho-associated protein kinaseImmunologyIn vivoMyofibroblastEx vivoInflammationRHOAInfiltration (medical)VinculinMethylglyoxalStreptozotocinCocaine dependenceWound healingFibroblastType I collagenEndothelial dysfunctionCollagen, type I, alpha 1SecretionConnective tissueSenescenceViability assayDiabetes mellitusCell growthMedicineFibronectinPlateletCell biology
5Publications
3H-index
12Citations
Publications 5
Newest
#1Ignacio N. Retamal (University of Los Andes)H-Index: 6
#1Ignacio N Retamal (University of Los Andes)H-Index: 1
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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OBJECTIVES: Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of myofibroblasts in periodontal wounds. MATERIAL AND METHODS: Type I diabetes was induced in rats through streptozotocin injection and periodontal wounds were performed. Wound healing was evaluated histologically at 2, 5, 7 and 15 days by measuring epithelial migration, neutrophil inf...
3 CitationsSource
#1Jassir Páez (Andrés Bello National University)H-Index: 1
#2Romina Hernández (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Patricio C. Smith (Andrés Bello National University)H-Index: 1
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BACKGROUND AND OBJECTIVE: Aging is characterized by a decline in tissue structure and function that may be explained by the development of cellular senescence. However, the acquisition of specific phenotypic responses in senescent gingival fibroblasts is still poorly understood. Here, we have analyzed whether proliferation of primary cultures of human gingival fibroblasts may affect different cell functions relevant to cellular senescence and tissue deterioration. METHODS: Human gingival fibrobl...
4 CitationsSource
#1Ignacio N. Retamal (UC: Pontifical Catholic University of Chile)H-Index: 6
#2Romina Hernández (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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Background: Glucose-derived metabolites may alter the structure and biologic properties of important proteins in periodontium, such as collagens. As a consequence, it is possible that collagen-binding cells may change their phenotypic traits. Although the glucose-derived product methylglyoxal (MGO) has been detected in periodontal lesions, the precise effect of collagen glycation on gingival connective tissue biology is not fully understood. The present study evaluates whether collagen glycation...
4 CitationsSource
#1Jaime Pereira (UC: Pontifical Catholic University of Chile)H-Index: 27
#2Claudia G. Sáez (UC: Pontifical Catholic University of Chile)H-Index: 13
Last. Jorge E. Jalil (UC: Pontifical Catholic University of Chile)H-Index: 26
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Abstract 2177 Background. Cocaine abuse is associated with an increased risk of cardiac and cerebrovascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood although intravascular thrombus formation and accelerated atherosclerosis are prominent findings. We have recently demonstrated that chronic cocaine use is associated with endothelial dysfunction (Saez et al. Thromb Res 2011; 12...
1 CitationsSource
#1Romina HernándezH-Index: 3
#2Luis A. CeaH-Index: 11
Last. Victoria VelardeH-Index: 19
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