Xueping Liu
Centre for Mental Health
GeneGenome-wide association studyEpidemiologyDuration (music)GenotypeSNPSingle-nucleotide polymorphismFetusAlleleHuman leukocyte antigenImmunologyGestational ageComorbidityPregnancyPhysiologyGestationGeneticsBioinformaticsMedicineQuantitative trait locusLocus (genetics)Biology
13Publications
6H-index
262Citations
Publications 11
Newest
#1Xueping Liu (Centre for Mental Health)H-Index: 1
#1Xueping Liu (Centre for Mental Health)H-Index: 6
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
1 CitationsSource
#1Xueping Liu (Centre for Mental Health)H-Index: 6
#2Ron Nudel (Lundbeck)H-Index: 3
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
Abstract Background Previous studies have indicated the bidirectionality between autoimmune and mental disorders. However, genetic studies underpinning the co-occurrence of the two disorders have been lacking. In this study, we examined the potential genetic contribution to the association between autoimmune and mental disorders and investigated the genetic basis of overall autoimmune disease. Methods We used diagnostic information from patients with seven autoimmune diseases and six mental diso...
6 CitationsSource
#1Line SkotteH-Index: 14
#2João FadistaH-Index: 26
Last. Bjarke FeenstraH-Index: 41
view all 39 authors...
Febrile seizures represent the most common type of pathological brain activity in young children and are influenced by genetic, environmental, and developmental factors. While usually benign, in a minority of cases, febrile seizures precede later development of epilepsy. Here, we conducted a genome-wide association study of febrile seizures with 7,635 cases and 93,966 controls identifying and replicating seven new loci, all with P < 5 x 10-10. Variants at two loci were functionally related to al...
1 CitationsSource
#1Xueping Liu (SSI: Statens Serum Institut)H-Index: 6
#2Dorte Helenius (CMHS: Mental Health Services)H-Index: 5
Last. Bjarke Feenstra (SSI: Statens Serum Institut)H-Index: 41
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The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10−14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than ...
20 CitationsSource
#2Anubha MahajanH-Index: 68
Last. Janine F. FelixH-Index: 57
view all 222 authors...
#1Xueping Liu (SSI: Statens Serum Institut)H-Index: 6
#2Dorte Helenius (Lundbeck)H-Index: 5
Last. Bjarke Feenstra (SSI: Statens Serum Institut)H-Index: 41
view all 74 authors...
The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. We conducted a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 was associated with gestational duration; the association was replicated in 9,291 additional infants (combined P = 3.96 x 10 -14 ). Analysis of 15,536 mother-child pairs showed that the association was driven by fetal rather t...
1 CitationsSource
#1Ge ZhangH-Index: 14
#1Ge ZhangH-Index: 3
Last. Louis J. MugliaH-Index: 74
view all 38 authors...
1 CitationsSource
#1Nerea Alonso (Edin.: University of Edinburgh)H-Index: 13
#2Karol Estrada (EUR: Erasmus University Rotterdam)H-Index: 59
Last. Stuart H. Ralston (Edin.: University of Edinburgh)H-Index: 110
view all 61 authors...
Objectives To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. Methods Here we conduct a genome-wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with a two-stage replication involving 1028 cases and 3762 controls. Potentially causal variants were identified using expression quantitative trait loci (eQTL) data from transiliac bone biopsies and bioinformatic s...
10 CitationsSource
#1Aurélien Macé (Swiss Institute of Bioinformatics)H-Index: 13
#2Marcus A. Tuke (University of Exeter)H-Index: 22
Last. Zoltán Kutalik (Swiss Institute of Bioinformatics)H-Index: 80
view all 106 authors...
There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to 191,161 adult samples from 26 cohorts. The study reveals five CNV associations at 1q21.1, 3q29, 7q11.23, 11p14.2, and 18q21.32 and confirms two known loci at 16p11.2 and 22q11.21, implicating at least one anthropometric trait. The discovered CNVs are recurrent and rare (0.01-0.2%),...
42 CitationsSource
#1Ge Zhang (Cincinnati Children's Hospital Medical Center)H-Index: 3
#1Ge Zhang (Cincinnati Children's Hospital Medical Center)H-Index: 14
Last. Louis J. Muglia (Cincinnati Children's Hospital Medical Center)H-Index: 74
view all 38 authors...
BackgroundDespite evidence that genetic factors contribute to the duration of gestation and the risk of preterm birth, robust associations with genetic variants have not been identified. We used large data sets that included the gestational duration to determine possible genetic associations. MethodsWe performed a genomewide association study in a discovery set of samples obtained from 43,568 women of European ancestry using gestational duration as a continuous trait and term or preterm (<37 wee...
175 CitationsSource