Li-Jun Wu
Shenyang Pharmaceutical University
Molecular biologyPharmacognosyOrganic chemistryChemistryApoptosisGlycosideTerpenoidHeLaProgrammed cell deathChromatographyDNA fragmentationCancer researchBiochemistryTraditional medicineMAPK/ERK pathwayStereochemistryCell cultureBiologyCell biologyCaspase
134Publications
30H-index
2,595Citations
Publications 129
Newest
#1Jia-Yu ZhangH-Index: 18
#2Lin-Yuan WangH-Index: 4
Last. Li-Jun WuH-Index: 20
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Source
#1Xiao-Xia Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Ke Zan (PKU: Peking University)H-Index: 10
Last. Peng-Fei Tu (Beijing University of Chinese Medicine)H-Index: 54
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Abstract Five new quinolone alkaloids, euocarpines A–E ( 16 – 20 ), four new natural products ( 1 , 4 , 12 , and 14 ), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5 , 7 – 11 , 13 ...
34 CitationsSource
#1Lin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 12
#2Lan Du (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Li-Jun Wu (SPU: Shenyang Pharmaceutical University)H-Index: 20
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Four new metabolites M-1 [1,2,18,19-tetradehydro-4-demethyl-3,17-epoxy-7,20(2H,19H)-cyclovobasan], M-2 [1,2,4,21,18,19-hexadehydro-4-demethyl-3,17-epoxy-7,20(2H,19H)-cyclovobasan], M-3 [1,2,18,19-tetradehydro-4-demethyl-4-formaldehyde-3,17-epoxy-7,20(2H,19H)-cyclovobasan], and M-4 [1,2,4,21,18,19-hexadehydro-4-demethyl-4-oxy-3,17-epoxy-7,20(2H,19H)-cyclovobasan] were isolated from the chloroform extract of koumine incubated with phenobarbital-treated rat liver microsomes. The structures of M-1, ...
11 CitationsSource
#1Nan Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Li Li (Peking Union Medical College)H-Index: 26
Last. Li-Jun Wu (SPU: Shenyang Pharmaceutical University)H-Index: 4
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Abstract Eight new trace indolomonoterpenic alkaloids ( 1 – 8 ) were isolated from the seeds of Strychnos nux-vomica . Their structures and absolute configurations were determined by extensive analysis of MS, NMR, CD, and ECD. The skeleton of compound 1 is an unprecedented 6/5/6/5/6/6/7 heptacyclic ring system. Compound 2 possesses a 2-pyridone moiety, and has not yet been found in strychnos alkaloids. Compounds 6 and 7 showed neuroprotective activities on PC12 cells with IE 50 values of 0.68–4....
13 CitationsSource
#1Jun-Hong Liu (Peking Union Medical College)H-Index: 4
#2Nan ZhaoH-Index: 7
Last. Wei-Bin TangH-Index: 1
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Six new quassinoids (1–6) and eight known compounds of this type (7–14) were isolated from the seeds of Brucea javanica. Their structures were elucidated by analysis of their spectroscopic data and from chemical evidence. Compounds 1–5 were found to be unusual quassinoids with a 2,3-seco A ring. The configurations at C-4 in 4 and 5 were determined by a difference circular dichroism method. In in vitro bioassays, 8 and 10 showed inhibitory activities for nitric oxide production in LPS-activated m...
27 CitationsSource
#1Li-Bo Wang (HMU: Harbin Medical University)H-Index: 1
#2Nai-Wei Dong (HMU: Harbin Medical University)H-Index: 1
Last. Li-Jun Wu (SPU: Shenyang Pharmaceutical University)H-Index: 20
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Four compounds were isolated from Daphne giraldii callus cells, and their structures were characterized as daphnenone (1), daphnolon (2), R-( − )-1-(4′-hydroxyphenyl)-3-hydroxy-5-phenyl-1,5-pentandione (3), and S-(+)-daphneolone-4′-O-β-d-glucoside (4) on the basis of MS, NMR spectrographic analysis, and chemical methods. All of the four compounds possessed C6-C5-C6 carbon skeleton, and among them, 3 and 4 were two new compounds. In activity screening test, compounds 1, 2, 3, and 4 showed differe...
5 CitationsSource
#1Zhibin Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#1Zhi‐Bin Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Li-Jun Wu (SPU: Shenyang Pharmaceutical University)H-Index: 20
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Four non-cyanogenic cyanoglucosides including hydranitrilosides A1, A2, B1, and B2 (1–4, resp.), together with a new phenolic glucoside, 3-hydroxy-4-methoxybenzoic acid 3-O-β-D-glucopyranoside (5), were isolated from the leaves of Hydrangea macrophylla. Their structures were determined on the basis of chemical and spectral evidence.
4 CitationsSource
#1Hai-Ying Ma (PRC: China Medical University (PRC))H-Index: 2
#2Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
Last. Li-Jun Wu (SPU: Shenyang Pharmaceutical University)H-Index: 20
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The 75% ethanol extract from roots of Salvia miltiorrhiza Bge. (Dan shen) afforded two new compounds, 3-hydroxy-2-(2′-formyloxy-1′-methylethyl)-8-methyl-1,4-phenanthrenedione (1), (8′R)-isosalvianolic acid C methyl ester (2), and 14 known compounds. Their structures were established on the basis of spectral analysis. The ability of the compounds to inhibit α-glucosidase activity and formation of advanced glycation end-products (AGEs) was evaluated. All compounds displayed various degrees of inhi...
29 CitationsSource
#1Di WuH-Index: 1
#2Ru Ping Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Magnoline ( 1 ), a new isoquinoline derivative, was isolated from the leaves of Magnolia sieboldii K. Koch (Magnoliaceae). Its structure was elucidated on the basis of spectral analysis including 1D, 2D NMR and HR-TOF-MS.
3 CitationsSource
#1Di WuH-Index: 1
#2Ya-Nan LiH-Index: 1
Last. Hui-Yuan GaoH-Index: 1
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Three compounds were isolated from the extract of Taxus cuspidta Sibe et Zucc with the column chromatography on silica gel and preparative HPLC methods.Their structures were identified according to the physicochemical properties and spectral analysis,and they were identified as(E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol(1),2-deacetoxy-7β,9α,10β-trideacetyltaxinine J(2) and(3aS,4aR,6S,8S,8aS,9R,10R,10aS)-benz[f]azulene-6,8,9,10(3H)-terol,3a,4,4a,5,6,7,8,8a,9,10-decahydro-10a-(1-hydroxyl-1-methyl...
1 Citations