Tsai Pei Hsieh
Taipei Medical University
Internal medicineEndocrinologyChemistryOsteoclastRUNX2OsteoblastNogginRANKLI?BaOsteoprotegerinIcariinOsteolysisBone morphogenetic protein 2Cell growthBone resorptionBone healingBiology
2Publications
2H-index
224Citations
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#1Tsai Pei Hsieh (TMU: Taipei Medical University)H-Index: 2
#2Shiow Yunn Sheu (TMU: Taipei Medical University)H-Index: 15
Last. Ming-Hong Chen (NYMU: National Yang-Ming University)H-Index: 16
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Abstract Icariin has been reported to enhance bone healing and treat osteoporosis. In this study, we examined the detail molecular mechanisms of icariin on lipopolysaccharide (LPS)-induced osteolysis. Our hypothesis is that icariin can inhibit osteoclast differentiation and bone resorption by suppressing MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis. After treatment with icariin, the activity of osteoclasts differentiation maker, tatrate resistances acid phosphatease (TRAP), significantly decr...
114 CitationsSource
#1Tsai Pei Hsieh (TMU: Taipei Medical University)H-Index: 2
#2Shiow Yunn Sheu (TMU: Taipei Medical University)H-Index: 15
Last. Man Hai Liu (TMU: Taipei Medical University)H-Index: 7
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Abstract Epimedii herba is one of the most frequently used herbs in formulas prescribed for the treatment of osteoporosis in China. The main active flavonoid glucoside extracted from Epimedium pubescens is Icariin, which has been reported to enhance bone healing and reduce osteoporosis occurrence. However, the detailed molecular mechanisms remain unclear. In this present study, we examine the molecular mechanisms of icariin by using primary osteoblast cell cultures obtained from adult mice. The ...
159 CitationsSource
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