Gaku Miyamura
Mie University
AnatomyInternal medicineGeologyDownregulation and upregulationEndocrinologySurgeryQuadrilateralCytotoxic T cellTRPV1Calcitonin gene-related peptideRetrospective cohort studyReceptorTumor necrosis factor alphaImmunohistochemistryMedical historyOsteoclastBone painPulmonary embolismDorsal root ganglionBack painOsteoporosisBisphosphonateTeriparatideArthroplastyIschiumMetaphysisDeep veinHyperalgesiaSclerostinCalcitoninPosterior columnThrombosisChronic painAtrophyPlantar surfaceMechanical HyperalgesiaSKELETAL PAINDisuse osteoporosisPositive responseInhibitory effectTissue volumeAnterior approachCtla 4igPlate fixationPosterior wallAnesthesiaRisk factorHindlimbOrthopedic surgeryMedicineOvariectomized rat
11Publications
3H-index
12Citations
Publications 11
Newest
#1Gaku Miyamura (Mie University)H-Index: 3
#2Hiroki Wakabayashi (Mie University)H-Index: 17
Last. Akihiro Sudo (Mie University)H-Index: 42
view all 7 authors...
OBJECTIVES: There are few reports on the comparison between teriparatide (PTH) and bisphosphonate (BP) in terms of osteoporosis pain-related behavior and immunohistochemical findings. The aims of t...
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This study aimed to evaluate skeletal pain associated with osteoporosis and to examine the inhibitory effects of cytotoxic T lymphocyte-associated antigen-4Ig (CTLA-4Ig) administration in ovariectomized (OVX) mice. Eight-week-old female ddY mice were assigned to three groups: sham-operated mice (SHAM) treated with vehicle, OVX mice treated with vehicle (OVX), and OVX mice treated with CTLA-4Ig (CTLA-4Ig). Vehicle or CTLA-4Ig was injected intraperitoneally, starting immediately after surgery. Aft...
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#1Hiroki WakabayashiH-Index: 17
#2Gaku MiyamuraH-Index: 3
Last. Akihiro Sudo (Mie University)H-Index: 42
view all 6 authors...
Interleukin-6 (IL-6) is widely accepted to stimulate osteoclasts. Our aim in this study was to examine whether the inhibitory effect of IL-6 on bone loss and skeletal pain associated with osteoporosis in hindlimb-unloaded (HU) mice in comparison with bisphosphonate. Eight-week-old male ddY mice were tail suspended for 2 weeks. Starting immediately after reload, vehicle (HU group), alendronate (HU-ALN group), or anti-IL-6 receptor antibody (HU-IL-6i group) was injected subcutaneously. After a 2-w...
1 CitationsSource
#1Kunihiro AsanumaH-Index: 16
#2Gaku MiyamuraH-Index: 3
Last. Tomohito HagiH-Index: 5
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#1Sho Kato (Mie University)H-Index: 4
#2Hiroki Wakabayashi (Mie University)H-Index: 17
Last. Akihiro Sudo (Mie University)H-Index: 42
view all 7 authors...
Purpose:The aim of this study was to examine the inhibitory effect of teriparatide (TPTD) on pain and on bone loss in ovariectomized (OVX) mice. The mechanism of osteoporotic pain in OVX mice was e...
3 CitationsSource
#1Hiroki Wakabayashi (Mie University)H-Index: 17
#2Sho Kato (Mie University)H-Index: 4
Last. Akihiro Sudo (Mie University)H-Index: 42
view all 6 authors...
The aim of this study was to evaluate skeletal pain associated with osteoporosis and examine the inhibitory effect of interleukin-6 (IL-6) on pain in ovariectomized (OVX) mice. The mechanism of osteoporotic pain in OVX mice was evaluated by examining pain-related behavior and immunohistochemistry. The effects of IL-6 receptor inhibitor (IL-6i) on these parameters were also assessed. Eight-week-old female ddY mice were ovariectomized and assigned to three groups: OVX mice treated with vehicle (OV...
3 CitationsSource
#1T. Nakagawa (Mie University)H-Index: 3
#2Hiroki Wakabayashi (Mie University)H-Index: 17
Last. Akihiro Sudo (Mie University)H-Index: 42
view all 7 authors...
Abstract Objective The aim of this study was to evaluate skeletal pain associated with immobility-induced osteoporosis and to examine the inhibitory effect of bisphosphonate (BP) administration on pain in hindlimb-unloaded (HU) mice. Methods The mechanism of osteoporotic pain in HU mice was evaluated through an examination of pain-related behavior, as well as immunohistochemical findings. In addition, the effects of alendronate (ALN), a potent osteoclast inhibitor, on these parameters were asses...
5 CitationsSource
#1Nobuto Nagao (Mie University)H-Index: 3
#2Hiroki Wakabayashi (Mie University)H-Index: 17
Last. Akihiro Sudo (Mie University)H-Index: 42
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Background Osteoporosis may cause not only fractures but also chronic back pain in elderly women. Teriparatide (TPTD) and alendronate (ALN) are widely used in clinical for treatment of osteoporosis. Several studies have demonstrated that TPTD and ALN treatments improved skeletal pain in osteoporosis patients. Objectives We investigated the effect of TPTD and ALN on pain-related behavior in ovariectomized (OVX) mice. And we investigated expression of inflammatory cytokines treated OVX mice. Metho...
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#1Sho KatoH-Index: 4
#2Hiroki Wakabayashi (Mie University)H-Index: 17
Last. Akihiro Sudo (Mie University)H-Index: 42
view all 5 authors...
Background Osteoporosis may cause not only fractures but also chronic back pain in elderly women. Bente reported that postmenopausal women with severe osteoporosis who were prescribed teriparatide (TPTD) in standard clinical practice had a reduction in back pain. However, there have been no reports regarding the effect of TPTD on pain in animal models of osteoporosis. Objectives The objective of the current study was to investigate the effect of TPTD on pain-related behavior in ovariectomized (O...
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#1Hiroki Wakabayashi (Mie University)H-Index: 17
#2Masahiro Hasegawa (Mie University)H-Index: 24
Last. Akihiro Sudo (Mie University)H-Index: 42
view all 6 authors...
Background Venous thromboembolism (VTE) [i.e., pulmonary embolism (PE) and deep vein thrombosis (DVT)] is a common complication during and after a hospital admission. Further, VTE is a leading cause of major complications and death after major orthopedic surgery. To avoid the development of VTE after orthopedic surgery, it is essential to reduce the onset of deep vein thrombosis (DVT) and to diagnose DVT early. It leads to early diagnosis to find a risk factor of DVT from medical history of the ...
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