Xiaoxuan Zhou
Sir Run Run Shaw Hospital
Biomedical engineeringMagnetic resonance imagingNanoparticleNanotechnologyPhotothermal therapyChemistryMaterials scienceIn vivoBiocompatibilityMRI contrast agentMetastasisEnhanced permeability and retention effectPolymerizationDendrimerCancer cell
11Publications
4H-index
51Citations
Publications 9
Newest
#1Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
#2Chengbin He (SRRSH: Sir Run Run Shaw Hospital)
Last. Hongjie Hu (SRRSH: Sir Run Run Shaw Hospital)H-Index: 9
view all 14 authors...
Theranostic nanoparticles (NPs) have emerged as promising candidates for cancer diagnosis and treatment. Manganese dioxide (MnO2)-based NPs are potential contrast agents with excellent paramagnetic property and biocompatibility, exhibiting satisfactory magnetic resonance imaging (MRI) effects and biological safety. Recently, hyaluronic acid (HA) has gained increasing interest due to its tumor-targeting ability, which can improve the tumor affinity of manganese dioxide (MnO2)-based NPs. In this s...
1 CitationsSource
#1Xiaodan Xu (ZJU: Zhejiang University)
#2Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
Last. Jianbin Tang (ZJU: Zhejiang University)H-Index: 31
view all 13 authors...
Liver metastasis (LM) occurs in various cancers, and its early and accurate diagnosis is of great importance. However, the detection of small LMs is still a great challenge because of the subtle differences between normal liver tissue and small metastases. Herein, we prepare glutathione (GSH)-responsive hyaluronic acid-coated iron oxide nanoparticles (HIONPs) for highly sensitive diagnosis of LMs through a facile one-pot method. HIONPs greatly enhance the signal of MRI in tumor metastases as T1 ...
Source
#1Bing Xiao (ZJU: Zhejiang University)H-Index: 3
#2Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 17 authors...
Nanotechnology has a remarkable impact on the preclinical development of future medicines. However, the complicated preparation and systemic toxicity to living systems prevent them from translation to clinical applications. In the present report, we developed a polyepicatechin-based on/off switchable ultra-sensitive magnetic resonance imaging (MRI) visible theranostic nanoparticle (PEMN) for image-guided photothermal therapy (PTT) using our strategy of integrating polymerization and biomineraliz...
Source
#1Dan Tian (ZJU: Zhejiang University)
#2Hongxia Xu (ZJU: Zhejiang University)H-Index: 3
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 10 authors...
Nanotheranostics (combined diagnosis and therapy) is emerging as the integral part of future therapeutic strategy. However, developing and fabrication of nanotheranostic module involves multistep processes and always faces formulation challenges. The complexity involved during its multi-step formulations hinders them from reproducible industrial production and clinical translation. Therefore, a facile synthesis for multifunctional nanotheranostics is critical to its translational success. In thi...
Source
#1Yuxin Han (ZJU: Zhejiang University)H-Index: 4
#2Xiaoxuan Zhou (ZJU: Zhejiang University)H-Index: 4
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 8 authors...
Abstract Hypoxia is one of the critical features in solid tumors, and hypoxia-targeting contrast agents (CAs) could greatly enhance the magnetic resonance imaging (MRI) of tumors by increasing its specificity and providing more diagnosis information. In this article, an internally hydroxy dendrimer of high molecular weight was facilely synthesized by “epoxy-amine” and “thiol-ene” reactions with a β-cyclodextrin (β-CD) as the core, and a hypoxia-targeting dendritic contrast agent (DCA) was synthe...
10 CitationsSource
#1Bing Xiao (ZJU: Zhejiang University)H-Index: 3
#2Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 11 authors...
Integration of biological macromolecules with inorganic materials via biomineralization has demonstrated great potential for development of nanotheranostic agents. To produce multifunctionality, integration of multiple components in the biomineralized theranostic agents is required; however, how to efficiently and reproducibly implement this is challenging. In this report, a universal biomineralization strategy is developed by incorporation of oxidization polymerization into albumin-templated bi...
20 CitationsSource
#1Mingchun Xia (ZJU: Zhejiang University)H-Index: 1
#2Mingzhou Ye (ZJU: Zhejiang University)H-Index: 10
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 9 authors...
Photothermal therapies (PPTs) with various light-absorbing materials have shown very promising therapeutic effects against cancers. However, their application was severely limited by the lack of accurate localization of tumors and real-time monitoring of the therapeutic process. Theranostic nanoparticles with both imaging and therapeutic functions are highly desired to develop imaging-mediated PPTs. Herein, we develop a facile one-pot method to synthesize a nanoparticle with functions of an MRI ...
2 CitationsSource
#1Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
#2Mingzhou Ye (ZJU: Zhejiang University)H-Index: 10
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 7 authors...
Metastasis is the main reason for cancer-associated mortality, and accurate diagnostic imaging of metastases is critical for the clinical administration and tailoring personalized treatments for metastatic tumors. However, magnetic resonance imaging of metastases in the liver is impeded by its low sensitivity because the currently used contrast agents accumulate in hepatocytes and Kupffer cells instead of cancer cells. Herein, a 4th generation zwitterionized biodegradable dendritic contrast agen...
10 CitationsSource
#1Yuxin Han (ZJU: Zhejiang University)H-Index: 4
#2Yue Qian (SRRSH: Sir Run Run Shaw Hospital)H-Index: 7
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 8 authors...
Dendrimers with uniform hyperbranched structures are ideal carriers for drug and imaging probe delivery; however, the complicated synthesis and poor biocompatibility of these molecules hinder their biological applications. In this study, a facile method for the synthesis of a biocompatible polyglycerol dendrimer (PGD) was developed by reducing the synthesis steps and simplifying purification with β-cyclodextrin (β-CD) as the core, and a zwitterionic surface of the dendrimer was achieved by modif...
11 CitationsSource