Vedang S. Uttarwar
University of California, San Diego
RecallQuality of lifeVerbal memoryAnatomyNeuriteDevelopmental psychologyJob designNeuropsychologyPathologyNonverbal communicationHippocampal formationDiffusion MRIDominance (genetics)PsychologyIntrusionConcordanceNeuroscienceCognitionLateralityCommon spatial patternExtant taxonCognitive psychologyCore languageSeparation (statistics)Cingulum (brain)EpilepsyTrail Making TestFornixEpilepsy syndromesDepression (differential diagnoses)Uncinate fasciculusArcuate fasciculusExecutive dysfunctionStriatumEntorhinal cortexTemporal lobeWhite matterWhite Matter InjuryDiffusion imagingInferior parietal cortexVerbal learningIn patientBrain radiationAge and genderProspective trialClinical settingsFree recallSpatial memoryRadiation therapyAudiologyNeuroimagingCognitive flexibilityClinical psychologyMedicineBehavioral patternSemantic networkEpisodic memoryWechsler Adult Intelligence ScaleFractional anisotropyRecognition memory
10Publications
5H-index
63Citations
Publications 7
Newest
#1Tobin J. Ehrlich (Palo Alto University)H-Index: 2
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonaldH-Index: 38
view all 10 authors...
Abstract Objective Individuals with temporal lobe epilepsy (TLE) often experience diminished quality of life (QoL). Although comorbid depression is one of the most recognized predictors of poor QoL in TLE, impairments in verbal memory (VM) and executive functioning (EF), have also been identified as risk factors, independent of other biological and psychosocial factors. In this study, we examine the contribution of depression, VM, and EF to QoL in 52 well-characterized medically-refractory TLE p...
4 CitationsSource
#1Yu-Hsuan A. Chang (UCSD: University of California, San Diego)H-Index: 7
#2Sogol Stephanie Javadi (UCSD: University of California, San Diego)H-Index: 3
Last. Carrie R. McDonald (SDSU: San Diego State University)H-Index: 38
view all 6 authors...
Abstract Blocked and event-related fMRI designs are both commonly used to localize language networks and determine hemispheric dominance in research and clinical settings. We compared activation profiles on a semantic monitoring task using one of the two designs in a total of 43 healthy individual to determine whether task design or subject-specific factors (i.e., age, sex, or language performance) influence activation patterns. We found high concordance between the two designs within core langu...
2 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Heather M. Holden (UCSD: University of California, San Diego)H-Index: 7
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 10 authors...
Abstract Individuals with chronic temporal lobe epilepsy (TLE) experience episodic memory deficits that may be progressive in nature. These memory decrements have been shown to increase with the extent of hippocampal damage, a hallmark feature of TLE. Pattern separation, a neural computational mechanism thought to play a role in episodic memory formation, has been shown to be negatively affected by aging and in individuals with known hippocampal dysfunction. Despite the link between poor pattern...
17 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Vedang S. Uttarwar (UCSD: University of California, San Diego)H-Index: 5
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 8 authors...
Abstract Objective Executive dysfunction is observed in a sizable number of patients with refractory temporal lobe epilepsy (TLE). The frontostriatal network has been proposed to play a significant role in executive functioning, however, because of the complex architecture of these tracts, it is difficult to generate measures of fiber tract microstructure using standard diffusion tensor imaging. To examine the association between frontostriatal network compromise and executive dysfunction in TLE...
10 CitationsSource
#1Lisa V. Graves (UCSD: University of California, San Diego)H-Index: 4
#2Charles C. Moreno (SDSU: San Diego State University)H-Index: 1
Last. Paul E. Gilbert (SDSU: San Diego State University)H-Index: 32
view all 12 authors...
Objective: Recall and recognition memory abilities are known to decline with increasing age, yet much of the evidence stems from studies that used simple measures of total target recall or recognition. The California Verbal Learning Test-Second Edition (CVLT-II) includes a new measure of recall discriminability that is analogous to recognition discriminability. These discriminability measures yield more thorough assessments of recall and recognition by accounting for intrusion and false positive...
9 CitationsSource
#1Yu-Hsuan A. Chang (UCSD: University of California, San Diego)H-Index: 7
#2Nobuko Kemmotsu (UCSD: University of California, San Diego)H-Index: 9
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 14 authors...
Abstract This study explored the relationships among multimodal imaging, clinical features, and language impairment in patients with left temporal lobe epilepsy (LTLE). Fourteen patients with LTLE and 26 controls underwent structural MRI, functional MRI, diffusion tensor imaging, and neuropsychological language tasks. Laterality indices were calculated for each imaging modality and a principal component (PC) was derived from language measures. Correlations were performed among imaging measures, ...
7 CitationsSource
#1Richard Q. Loi (UCSD: University of California, San Diego)H-Index: 4
#2Kelly M. Leyden (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 9 authors...
SummaryObjective Diffusion tensor imaging (DTI) has become a popular tool for delineating the location and extent of white matter injury in temporal lobe epilepsy (TLE). However, DTI yields nonspecific measures that are confounded by changes occurring within both the intracellular and extracellular environments. This study investigated whether an advanced diffusion method, restriction spectrum imaging (RSI) could provide a more robust measure of white matter injury in TLE relative to DTI due to ...
9 CitationsSource