Qinghui Wang
Memorial Sloan Kettering Cancer Center
Drug resistanceCancerOrganic chemistryAqueous solutionChemistryApoptosisIn vitroMicrotubuleIn vivoSurvivinWestern blotPrimary (chemistry)ColchicineChemotherapyInflammasomePaclitaxelInhibitor of apoptosisMelanomaCyclin B1PancaMetastasisDerivative (chemistry)Triple-negative breast cancerPancreatic cancerOvarian cancerSolventCell cycleCancer researchBreast cancerCell growthStereochemistryMedicineIntracellularTubulinTernary complexBiologyCell biologyCancer cellPharmacology
23Publications
9H-index
195Citations
Publications 22
Newest
#1Humayun Sharif (Boston Children's Hospital)H-Index: 7
#2L. Robert Hollingsworth (Boston Children's Hospital)H-Index: 4
Last. Hao Wu (Boston Children's Hospital)H-Index: 108
view all 12 authors...
Summary CARD8 detects intracellular danger signals and forms a caspase-1 activating inflammasome. Like the related inflammasome sensor NLRP1, CARD8 autoprocesses into noncovalently associated N-terminal (NT) and C-terminal (CT) fragments and binds the cellular dipeptidyl peptidases DPP8 and 9 (DPP8/9). Certain danger-associated signals, including the DPP8/9 inhibitor Val-boroPro (VbP) and HIV protease, induce proteasome-mediated NT degradation and thereby liberate the inflammasome-forming CT. He...
1 CitationsSource
#1Hongmei CuiH-Index: 1
#1Hongmei Cui (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Wei LiH-Index: 54
view all 4 authors...
Melanoma is one of the deadliest skin cancers having a five-year survival rate around 15-20%. An overactivated MAPK/AKT pathway is well-established in BRAF mutant melanoma. Vemurafenib (Vem) was the first FDA-approved BRAF inhibitor and gained great clinical success in treating late-stage melanoma. However, most patients develop acquired resistance to Vem within 6-9 months. Therefore, developing a new treatment strategy to overcome Vem-resistance is highly significant. Our previous study reporte...
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#1Humayun Sharif (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 7
#1H. Sharif (MSK: Memorial Sloan Kettering Cancer Center)
Last. Hao Wu (Boston Children's Hospital)H-Index: 108
view all 7 authors...
CARD8 is a germline-encoded pattern recognition receptor that detects intracellular danger signals. Like the related inflammasome sensor NLRP1, CARD8 undergoes constitutive autoprocessing within its function-to-find domain (FIIND), generating two polypeptides that stay associated and autoinhibited. Certain pathogen- and danger-associated activities, including the inhibition of the serine dipeptidases DPP8 and DPP9 (DPP8/9), induce the proteasome-mediated degradation of the N-terminal (NT) fragme...
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#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#1Vivek Kumar Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 5
view all 14 authors...
Abstract In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the ...
2 CitationsSource
#1Shanshan Deng (UTHSC: University of Tennessee Health Science Center)H-Index: 5
#2Raisa Krutilina (UTHSC: University of Tennessee Health Science Center)H-Index: 8
Last. Wei Li (UTHSC: University of Tennessee Health Science Center)H-Index: 54
view all 10 authors...
Triple-negative breast cancer (TNBC) accounts for ~15% of breast cancer cases in the United States. TNBC has poorer overall prognosis relative to other molecular subtypes due to rapid onset of drug resistance to conventional chemotherapies and increased risk of visceral metastases. Taxanes like paclitaxel are standard chemotherapies that stabilize microtubules, but their clinical efficacy is often limited by drug resistance and neurotoxicities. We evaluated the preclinical efficacy of a novel, p...
5 CitationsSource
#1Guannan Zhao (UTHSC: University of Tennessee Health Science Center)H-Index: 9
#2Qinghui Wang (UTHSC: University of Tennessee Health Science Center)H-Index: 9
Last. Junming Yue (UTHSC: University of Tennessee Health Science Center)H-Index: 34
view all 12 authors...
Survivin, a member of the inhibitor of apoptosis (IAP) family, is upregulated in multiple cancers including ovarian cancer, but is rarely detectable in normal tissues. We previously reported that survivin promoted epithelial to mesenchymal transition (EMT) in ovarian cancer cells, suggesting that survivin may contribute to ovarian tumor metastasis and chemoresistance. In this study, we tested whether knockout or pharmacological inhibition of survivin overcomes chemoresistance and suppresses tumo...
11 CitationsSource
#1Vivek K. KashyapH-Index: 8
#2Bilal Bin HafeezH-Index: 29
Last. Subhash C. ChauhanH-Index: 49
view all 10 authors...
Background: Pancreatic cancer (PanCa) is one of the leading causes of cancer-related mortality in the United States due to very limited therapeutic options. Thus, developing novel therapeutic strategies will help for the management of this disease. We recently identified VERU-111, a novel synthetic molecule which showed potent anti-cancer effect against PanCa via targeting clinically important βIII and βIV tubulin isoforms. In this study, we synthesized and characterized its novel nanoformulatio...
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#1Qinghui Wang (UTHSC: University of Tennessee Health Science Center)H-Index: 9
#2Kinsie E. Arnst (UTHSC: University of Tennessee Health Science Center)H-Index: 7
Last. Wei Li (Sichuan University)H-Index: 54
view all 8 authors...
ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. Guided by the crystal structure of ABI-231 in complex with tubulin, we performed structure–activity relationship studies around the 3-indole moiety that led to the discovery of several potent ABI-231 analogues, most notably 10ab and 10bb. The crystal structures of 10ab and 10bb in complex with tubulin confirmed their improved ...
7 CitationsSource
#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#2Qinghui Wang (UTHSC: University of Tennessee Health Science Center)H-Index: 9
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 13 authors...
The management of pancreatic cancer (PanCa) is exceptionally difficult due to poor response to available therapeutic modalities. Tubulins play a major role in cell dynamics, thus are important molecular targets for cancer therapy. Among various tubulins, βIII and βIV-tubulin isoforms have been primarily implicated in PanCa progression, metastasis and chemo-resistance. However, specific inhibitors of these isoforms that have potent anti-cancer activity with low toxicity are not readily available....
11 CitationsSource
#1Qinghui Wang (UTHSC: University of Tennessee Health Science Center)H-Index: 9
#2Kinsie E. Arnst (UTHSC: University of Tennessee Health Science Center)H-Index: 7
Last. Wei Li (Guangzhou Medical University)H-Index: 54
view all 11 authors...
Colchicine binding site inhibitors (CBSIs) hold great potential in developing new generations of antimitotic drugs. Unlike existing tubulin inhibitors such as paclitaxel, they are generally much less susceptible to resistance caused by the overexpression of drug efflux pumps. The 3,4,5-trimethoxyphenyl (TMP) moiety is a critical component present in many CBSIs, playing an important role in maintaining suitable molecular conformations of CBSIs and contributing to their high binding affinities to ...
18 CitationsSource