Tetsuo Aida
Daiichi Sankyo
AntigenMolecular biologyAntibodyChemistryImmunologyAllergyPrimary and secondary antibodiesT cellBenzylpenicillinHumoral immunityKeyhole limpet hemocyaninGuinea pigPeptideTrastuzumabImmunopathologyToxicityStrain (chemistry)MedicineBiologyImmune systemPharmacology
14Publications
6H-index
239Citations
Publications 13
Newest
Guinea pigs of two strains, outbred Hartley and inbred Strain 2, were immunized sub-cutaneously with cephalothin (CET, 20 mg/body) alone, without adjuvant. Immune responses to the antibiotic were assessed by guinea-pig passive cutaneous anaphylaxis (GP-PCA) and active systemic anaphylaxis (GP-ASA) reactions. The immune response to CET in the female Hartley guinea pigs was higher than that in the males. In contrast, no difference in response to CET in Strain 2 guinea pigs was observed between mal...
4 CitationsSource
The present experiments were undertaken to clarify the differences in humoral immune response to two β-lactam antibiotics, benzylpenicillin potassium (PcG) and cephalothin sodium (CET), in guinea-pig strains. Guinea pigs of three different strains, Hartley, Strain 2 and Strain 13, were immunized subcutaneously with PcG (10mg/body) 1 or 3 times a week, 10 times in total, or with CET (20 mg/body) 3 times a week, 12 times in total. Humoral immune responses to the two antibiotics were assessed by pa...
3 CitationsSource
: The present experiments were undertaken to clarify the differences in humoral and cellular immune responses to a low-molecular compound, sodium 2,4,6-trinitrobenznnesul fonate dihydrate (TNBS) in guinea-pig strains. Guinea pigs of three different strains, Hartley, Strain 2 and Strain 13, were immunized subcutaneously with TNBS (3 mg/body) 2 or 3 times a week, 9 times in total. Humoral immune responses to TNBS were assessed by passive cutaneous anaphylaxis (PCA) and Arthus reaction, and cellula...
5 CitationsSource