Ryan Clay
Mayo Clinic
CancerInternal medicineRadiologySurgeryOncologyDermatologyIntensive care medicineFEV1/FVC ratioLung volumesLung cancerInterstitial lung diseaseElastographyLungNational Lung Screening TrialNodule (medicine)BronchoscopyAL amyloidosisAdenocarcinoma of the lungAdenocarcinomaLung ultrasoundLongitudinal predictionCt analysisEndobronchial ultrasoundMedicineCohortSurface waveClassifier (UML)
Publications 22
#1Ryan ClayH-Index: 6
#2Brian J. BartholmaiH-Index: 33
Last. Xiaoming ZhangH-Index: 29
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Purpose:Optimal strategies to detect early interstitial lung disease (ILD) are unknown. ILD is frequently subpleural in distribution and affects lung elasticity. Lung ultrasound surface wave elastography (LUSWE) is a noninvasive method of quantifying superficial lung tissue elastic properties. In LU
18 CitationsSource
#1Joseph Jacob (UCL: University College London)H-Index: 3
#1Joseph Jacob (UCL: University College London)H-Index: 23
Last. Athol U. WellsH-Index: 122
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The advent of antifibrotic agents [1, 2] as standard of care in idiopathic pulmonary fibrosis (IPF) requires that new non-inferiority IPF drug trials will need to identify smaller declines of forced vital capacity (FVC). Marginal annualised FVC declines (between 5.00 and 9.99%) are particularly challenging to interpret as they might reflect measurement variation or genuine clinical deterioration [3]. Following on from previous baseline-only CT analyses [4], the current study examined whether cha...
8 CitationsSource
#1Shireen Mirza (Mayo Clinic)H-Index: 4
#2Ryan Clay (Mayo Clinic)H-Index: 6
Last. Paul D. Scanlon (Mayo Clinic)H-Index: 40
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Abstract Global Strategy for the Diagnosis, Management, and Prevention of COPD 2018 is a consensus report published periodically since 2001 by an international panel of health professionals from respiratory medicine, socioeconomics, public health, and education comprising the Global Initiative for Chronic Obstructive Lung Disease (GOLD). The GOLD documents endeavor to incorporate latest evidence and expert consensus and are intended for use as "strategy documents" for implementation of effective...
127 CitationsSource
#1Tobias PeikertH-Index: 31
#2Fenghai DuanH-Index: 29
Last. Fabien MaldonadoH-Index: 35
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#1Ryan Clay (Mayo Clinic)H-Index: 6
#2James P. UtzH-Index: 24
1 CitationsSource
#1Ryan Clay (Mayo Clinic)H-Index: 6
#2Srinivasan Rajagopalan (Mayo Clinic)H-Index: 19
Last. Brian J. Bartholmai (Mayo Clinic)H-Index: 33
view all 6 authors...
The majority of incidentally and screen-detected lung cancers are adenocarcinomas. Optimal management of these tumors is clinically challenging due to variability in tumor histopathology and behavior. Invasive adenocarcinoma (IA) is generally aggressive while adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) may be extremely indolent. Computer Aided Analysis and Risk Yield (CANARY) is a quantitative computed tomography (CT) analysis tool that allows non-invasive assessment...
3 CitationsSource
#1Erica C. Nakajima (Vandy: Vanderbilt University)H-Index: 1
#2Michael P. Frankland (Vandy: Vanderbilt University)H-Index: 2
Last. Fabien Maldonado (Vandy: Vanderbilt University)H-Index: 35
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: Lung adenocarcinoma (ADC), the most common lung cancer type, is recognized increasingly as a disease spectrum. To guide individualized patient care, a non-invasive means of distinguishing indolent from aggressive ADC subtypes is needed urgently. Computer-Aided Nodule Assessment and Risk Yield (CANARY) is a novel computed tomography (CT) tool that characterizes early ADCs by detecting nine distinct CT voxel classes, representing a spectrum of lepidic to invasive growth, within an ADC. CANARY ch...
4 CitationsSource
#1Tobias Peikert (Mayo Clinic)H-Index: 31
#2Fenghai Duan (Brown University)H-Index: 29
Last. Fabien Maldonado (Vandy: Vanderbilt University)H-Index: 35
view all 10 authors...
Purpose Optimization of the clinical management of screen-detected lung nodules is needed to avoid unnecessary diagnostic interventions. Herein we demonstrate the potential value of a novel radiomics-based approach for the classification of screen-detected indeterminate nodules. Material and methods Independent quantitative variables assessing various radiologic nodule features such as sphericity, flatness, elongation, spiculation, lobulation and curvature were developed from the NLST dataset us...
24 CitationsSource
#1Xiaoming Zhang (Mayo Clinic)H-Index: 29
#2Boran Zhou (Mayo Clinic)H-Index: 15
Last. Sanjay Kalra (Mayo Clinic)H-Index: 28
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A lung ultrasound surface wave elastography (LUSWE) technique is developed for assessing interstitial lung disease (ILD). In LUSWE, a 0.1 second harmonic vibration is generated on the chest wall of a subject using a handheld vibrator. An ultrasound probe is aligned with the vibration indenter in the same intercostal region to measure the generated surface wave speed of the lung. A human subject is examined in a sitting position. The lung is tested at the total lung volume. The upper anterior lun...
7 CitationsSource