Haixia Zhao
China Three Gorges University
Downregulation and upregulationEndocrinologyDNA damageAndrologyTumor necrosis factor alphaChemistryApoptosisSuperoxide dismutaseOxidative stressWestern blotInflammationCHOPEpimediumMitochondrionNormal dietAgeingSignal transductionMedicineBiologyPharmacology
38Publications
7H-index
132Citations
Publications 21
Newest
#1Zhou Zhiyong (CTGU: China Three Gorges University)H-Index: 9
#2Menghan He (CTGU: China Three Gorges University)
Last. Ting Wang (WUST: Wuhan University of Science and Technology)
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#1Yuan Yang (CTGU: China Three Gorges University)
#2Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
Last. Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
view all 8 authors...
#1Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
#2Xu You (CTGU: China Three Gorges University)H-Index: 1
Last. Ding Yuan (CTGU: China Three Gorges University)H-Index: 10
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Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting. However, whether icariin improves age-related degeneration of testicular function via protection from Sertoli cell injury remains unclear. In the present study, we evaluated the protective effect of icariin on Sertoli cell injury and explored the possible mechanism(s) in vivo...
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#1Wan JingzhiH-Index: 5
#2Rui WangH-Index: 1
Last. Ting WangH-Index: 11
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BACKGROUND: Oxidative stress and mitochondrial dysfunction play a vital role in the pathogenesis of brain aging. Saponins from Panax japonicus (SPJ) have attracted much attention for its potential to attenuate age-related oxidative stress as the main ingredient in rhizomes of Panax japonicus. OBJECTIVE: This study aimed to investigate the neuroprotective effects of SPJ on natural aging rats as well as the underlying mechanisms regarding oxidative stress and mitochondrial pathway. METHODS: Spragu...
1 CitationsSource
#1Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
#2Na Ma (CTGU: China Three Gorges University)H-Index: 2
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
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Abstract Activation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) and mitochondrial apoptotic pathway serves as a central regulator for maintaining cell function and survival, and is associated with ageing and spermatogenesis. However, changes in UPR activation and mitochondrial apoptotic pathway in the testis during ageing remain unclear. In this study, we hypothesized that UPR activation declines and the mitochondrial apoptotic pathway is activated in the testis duri...
3 CitationsSource
#1Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
#2Na Ma (CTGU: China Three Gorges University)H-Index: 2
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
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: It has been demonstrated that excessively activated endoplasmic reticulum stress (ERS) is closely associated with ageing-related diseases and male reproductive dysfunction. Wuzi Yanzong recipe (WZ) is a classical Traditional Chinese Medicine prescription for treatment of male reproductive system diseases. However, it remains unknown whether WZ improves testicular dysfunction with ageing via ERS. In this study, we investigated the protective effects and its mechanism of WZ on testicular dysfunc...
5 CitationsSource
#1Na Ma (CTGU: China Three Gorges University)H-Index: 2
#2Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
Last. Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
view all 8 authors...
: To study the protective effects of Wuzi Yanzong recipe on testis germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress (ERS), 16-month-old male SPF grade SD rats were randomly divided into three groups: ageing model group, and low and high-dose Wuzi Yanzong recipe groups (WZ, 1 and 4 g·kg⁻¹), with 10 rats in each group. In addition, 2-month-old SD male rats were used as adult control group. The ageing model group and the adult control group were fed with normal diet f...
Source
#1Na Ma (CTGU: China Three Gorges University)H-Index: 2
#2Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
view all 8 authors...
To study the protective effects of Wuzi Yanzong recipe on DNA oxidative damage of testis germ cells in natural ageing rats based on Nrf2/HO-1 signaling pathway and base excision repair (BER). In the study, 16-month-old SPF grade male SD rats were randomly divided into three groups, namely ageing model group, and low and high-dose Wuzi Yanzong recipe groups (WZ, 1, 4 g·kg⁻¹). In addition, 2-month-old SD rats were used as adult control group (10 rats in each group). The ageing model group and the ...
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#1Qian Chen (CTGU: China Three Gorges University)H-Index: 1
#2Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
view all 8 authors...
Objective To establish a model of decline in secretion of senescent TM4 cells in vitro induced by D-galactose (D-gal). Methods Different concentrations of D-Gal (25, 50, 100, 150, 200 and 250 mmol/L) were used to induce TM4 cell senescence. The viability of TM4 cells was detected by MTT assay. The cell cycle was analyzed by flow cytometry. The cell morphology was observed by light microscopy and the percentage of senescent cells was observed by senescence-associated β-galactosidase (SA-β-Gal) st...
1 Citations
#1Na Ma (CTGU: China Three Gorges University)H-Index: 2
#2Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
view all 7 authors...
To study the protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats, SPF grade 16-month-old SD male rats were randomly divided into three groups: ageing model group, low and high dose Wuzi Yanzong recipe groups (WZ, 1, 4 g·kg⁻¹). In addition, 2-month-old SD rats were used as adult control group (10 rats in each group). The ageing model group and the adult control group were fed with normal diet for 4 months. Wuzi Yanzong groups received medicated f...
1 CitationsSource
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