Wai-Sum Lau
Hong Kong Polytechnic University
PhosphorylationASK1EndocrinologyMAP kinase kinase kinaseMAP2K7ReceptorEstrogen receptor alphaKinaseGrowth factorTyrosine phosphorylationMAPK/ERK pathwayCell growthSignal transductionCell cultureCyclin-dependent kinase 2Estrogen receptorBiologyMitogen-activated protein kinase kinaseCell biologyProtein kinase A
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#1Wai-Sum Lau (PolyU: Hong Kong Polytechnic University)H-Index: 3
#2Wen Fang Chen (PolyU: Hong Kong Polytechnic University)H-Index: 11
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 36
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Background and purpose: The present study was designed to determine how ginsenoside Rg1, an active ingredient in ginseng root, exerts its oestrogenic effects. We hypothesize that Rg1 may exert oestrogen-like actions in MCF-7 cells by activating the mitogen-activated protein kinase (MAPK) pathway in a ligand-independent manner. Experimental approach: MCF-7 cells were co-incubated with the MAPK inhibitor PD98059 to determine whether the stimulant effects of Rg1 on cell proliferation, the induction...
62 CitationsSource
#1Wai-Sum Lau (PolyU: Hong Kong Polytechnic University)H-Index: 3
#2Robbie Yat-Kan Chan (PolyU: Hong Kong Polytechnic University)H-Index: 11
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 36
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Abstract Ginsenoside Rg1, an active ingredient commonly found in ginseng root, was previously demonstrated to be a phytoestrogen that exerted estrogen-like activity without direct interaction with estrogen receptors (ERs) in human breast cancer (MCF-7) cells. The present study was designed to determine the molecular mechanism by which Rg1 exerted estrogenic effects. Co-incubation of MCF-7 cells with 1 μM of ER antagonist ICI182780 abolished the inductive effects of Rg1 on pS2 expression as well ...
78 CitationsSource
#1Wen Fang Chen (PolyU: Hong Kong Polytechnic University)H-Index: 11
#2Wai-Sum Lau (PolyU: Hong Kong Polytechnic University)H-Index: 3
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 36
view all 5 authors...
Ginsenoside Rg1, an active ingredient in ginseng, was previously shown to be a novel class of potent phytoestrogen. The present study aims at investigating the molecular mechanisms involved in mediating its actions in human breast cancer (MCF-7) cells. Rg1 (1 pM) stimulates cell proliferation (P<0.01) and estrogen-responsive pS2 mRNA expression (P<0.05) without alteration of estrogen receptor alpha (ERα) protein or mRNA expression in MCF-7 cells. In addition, 10−14–10−4 M of Rg1 does not demonst...
51 CitationsSource
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